Preparation and Characterization of Highly Porous Direct Compression Carrier Particles with Improved Drug Loading During an Interactive Mixing Process

As a disease skin cancer has obtained different characteristics over the decades. Solar radiation that contains ultraviolet ray is the prime cause of skin cancer. In this present research, the nano-precipitation method was applied for preparing Quercetin loaded Nanoparticle (Qu-Nps) with much enhanced loading properties and improves incorporation of corresponding drugs. At the same time, the Quadratic model that takes help of the Response Surface Method was applied to observe the effects of some specific parameters maintained in the development of nanoparticle. Here, the sonication time was 20 min and delivery system F6 (with Drug: Polymer ratio of 1:45) provided optimum drug entrapment ability which is 70%. The optimized formulation for average size was almost 102.39 ±7.64 nm with zeta potential diameter averaging -28.43mV. Quercetin is a dietary flavonoid possessing multidimensional properties that is used in various other diseases including viral infection, bacterial infection, diabetes mellitus, and cancer. All outcomes support the view that Quercetin loaded nanoparticles (Qu-Nps) has high entrapment and drug loading abilities.

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On the Drug-Loading Capacity of Pectin Powder for Direct Compression

AAPS PharmSciTech ◽

10.1208/s12249-012-9785-4 ◽

2012 ◽

Vol 13 (2) ◽

pp. 601-604

Author(s):

Ingunn Tho ◽

Katharina Picker-Freyer ◽

Linda Salbu ◽

Annette Bauer-Brandl

Keyword(s):

Drug Loading ◽

Direct Compression ◽

Loading Capacity

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Thermal and morphological characterization of highly porous nanocomposites for possible application in potassium controlled release

Journal of Thermal Analysis and Calorimetry ◽

10.1007/s10973-017-6755-9 ◽

2017 ◽

Vol 131 (3) ◽

pp. 2205-2212 ◽

Cited By ~ 5

Author(s):

Carlos Roberto Ferreira Junior ◽

Fabrício Nunes Tanaka ◽

Adriel Bortolin ◽

Márcia Regina de Moura ◽

Fauze Ahmad Aouada

Keyword(s):

Controlled Release ◽

Morphological Characterization ◽

Porous Nanocomposites ◽

Highly Porous

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Characterization of Drug Loading into Swellable Polymers by Surface Analysis

Polymers in Medicine II ◽

10.1007/978-1-4613-1809-5_30 ◽

1986 ◽

pp. 397-407

Author(s):

Fabio Carli ◽

Italo Colombo ◽

Mara Lovrecich ◽

Fulvio Rubessa ◽

Clara Torricelli

Keyword(s):

Surface Analysis ◽

Drug Loading

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Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: Stability, solubility, lipophilicity and ionization

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2014.07.033 ◽

2014 ◽

Vol 473 (1-2) ◽

pp. 528-535 ◽

Cited By ~ 12

Author(s):

Esther See ◽

Wenli Zhang ◽

Jianping Liu ◽

Darren Svirskis ◽

Bruce C. Baguley ◽

...

Keyword(s):

Active Drug ◽

Drug Loading ◽

Physicochemical Characterization ◽

Liposomal Formulation

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PREPARATION AND CHARACTERIZATION OF GLYCYRRHETINIC ACID-MODIFIED POLOXAMER 188/CHITOSAN NANOPARTICLES

NANO ◽

10.1142/s1793292013500422 ◽

2013 ◽

Vol 08 (04) ◽

pp. 1350042 ◽

Cited By ~ 1

Author(s):

JING WANG ◽

LI GUO ◽

LI FANG MA

Keyword(s):

High Performance ◽

Drug Loading ◽

Chitosan Nanoparticles ◽

Spherical Shape ◽

Glycyrrhetinic Acid ◽

Poloxamer 188 ◽

H Nmr ◽

Ft Ir

In this paper, we firstly synthesized glycyrrhetinic acid-modified double amino-terminated poloxamer 188 (GA–NH–POLO–NH–GA). The structure of the synthesized compound was confirmed by 1H-NMR and Fourier transform infrared (FT-IR) spectroscopy. Then the nanoparticles composed of GA–NH–POLO–NH–GA/chitosan (GA–NH–POLO–NH–GA/CTS) were prepared by an ionic gelation process. The characterization of the nanoparticles was measured by dynamic light scattering (DLS) and scanning electron microscope (SEM). The results showed that the nanoparticles were well dispersed with a spherical shape and the particle size was distributed between 100 nm and 300 nm. The cytotoxicity based on MTT assay against cells (QGY-7703 cells and L929 cells) showed that the nanoparticles had low toxicity and good biocompatibility. The encapsulation efficiency and drug loading of 5-fluorouracil-loaded nanoparticles (5-FU nanoparticles) were measured by high-performance liquid chromatography (HPLC) and fluorescence spectroscopy, ultraviolet-visible (UV-vis) absorbance. The encapsulation of 5-Fu-loaded CTS nanoparticles was 12.8% and the drug loading was 2.9%, while the encapsulation of 5-Fu-loaded GA–NH–POLO–NH–GA/CTS nanoparticles was 20.9% and the drug loading was 3.36%. The release profile showed that the GA–NH–POLO–NH–GA/CTS nanoparticles were available for sustained release of 5-Fu. The GA–NH–POLO–NH–GA/CTS nanoparticles have a higher affinity to the QGY-7703 cells, so indicated that the GA–NH–POLO–NH–GA/CTS nanoparticles have the capacity of liver-targeting in vitro.

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Fabrication and characterization of potassium titanate whisker by simple mixing process

10.1063/1.5047121 ◽

2018 ◽

Author(s):

Yeon-Bin Choi ◽

Jeong-Hun Son ◽

Dong Gyu Lee ◽

Dong-Sik Bae

Keyword(s):

Mixing Process ◽

Potassium Titanate ◽

Fabrication And Characterization

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Natural Diatom Biosilica as Microshuttles in Drug Delivery Systems

Pharmaceutics ◽

10.3390/pharmaceutics11100537 ◽

2019 ◽

Vol 11 (10) ◽

pp. 537 ◽

Cited By ~ 10

Author(s):

Joachim Delasoie ◽

Fabio Zobi

Keyword(s):

Drug Delivery ◽

Targeted Delivery ◽

Drug Delivery Systems ◽

Binding Capacity ◽

Specific Binding ◽

Drug Loading ◽

Delivery Systems ◽

Biophysical Properties ◽

Toxic Material ◽

Highly Porous

Unicellular diatom microalgae are a promising natural resource of porous biosilica. These microorganisms produce around their membrane a highly porous and extremely structured silica shell called frustule. Once harvested from living algae or from fossil sediments of diatomaceous earth, this biocompatible and non-toxic material offers an exceptional potential in the field of micro/nano-devices, drug delivery, theranostics, and other medical applications. The present review focused on the use of diatoms in the field of drug delivery systems, with the aim of presenting the different strategies implemented to improve the biophysical properties of this biosilica in terms of drug loading and release efficiency, targeted delivery, or site-specific binding capacity by surface functionalization. The development of composite materials involving diatoms for drug delivery applications is also described.

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Synthesis and characterization of magnetic chitosan microspheres for drug delivery

RSC Advances ◽

10.1039/c9ra10792d ◽

2020 ◽

Vol 10 (12) ◽

pp. 7163-7169

Author(s):

Xin Li ◽

Danlin Zeng ◽

Ping Ke ◽

Guanghui Wang ◽

Dengke Zhang

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Drug Loading ◽

Synthesis And Characterization ◽

Loading Capacity ◽

Microemulsion Polymerization ◽

Magnetic Microsphere ◽

Magnetic Chitosan Microspheres ◽

Protein Drug Delivery

A novel magnetic microsphere was prepared by the simple microemulsion polymerization for protein drug delivery systems. This magnetic microsphere exhibited good magnetism and superior drug loading capacity and evident sustained-release performance.

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