Development and Characterization of Quercetin Loaded Nanoparticle for Skin Cancer

2019 ◽  
Vol 32 (1) ◽  
pp. 1-6
Author(s):  
Nikita Verma
Keyword(s):  
Skin Cancer ◽  
Drug Loading ◽  
Quadratic Model ◽  
Precipitation Method ◽  
Dietary Flavonoid ◽  
Ultraviolet Ray ◽  
Average Size ◽  
Different Characteristics ◽  
Polymer Ratio

As a disease skin cancer has obtained different characteristics over the decades. Solar radiation that contains ultraviolet ray is the prime cause of skin cancer. In this present research, the nano-precipitation method was applied for preparing Quercetin loaded Nanoparticle (Qu-Nps) with much enhanced loading properties and improves incorporation of corresponding drugs. At the same time, the Quadratic model that takes help of the Response Surface Method was applied to observe the effects of some specific parameters maintained in the development of nanoparticle. Here, the sonication time was 20 min and delivery system F6 (with Drug: Polymer ratio of 1:45) provided optimum drug entrapment ability which is 70%. The optimized formulation for average size was almost 102.39 ±7.64 nm with zeta potential diameter averaging -28.43mV. Quercetin is a dietary flavonoid possessing multidimensional properties that is used in various other diseases including viral infection, bacterial infection, diabetes mellitus, and cancer. All outcomes support the view that Quercetin loaded nanoparticles (Qu-Nps) has high entrapment and drug loading abilities.

Preparation and Characterization of Nanocrystalline CaO-ZrO2 Powders by Microwave Pyrolysis

2014 ◽  
Vol 602-603 ◽  
pp. 97-100
Author(s):  
Bing Bing Fan ◽  
Ke Ke Guan ◽  
Hao Chen ◽  
Xiao Xuan Pian ◽  
Chen Yang Wang ◽  
...  
Keyword(s):  
Phase Transition ◽  
Reaction Temperature ◽  
Pyrolysis Temperature ◽  
Precipitation Method ◽  
Microwave Pyrolysis ◽  
Model Chamber ◽  
Co Precipitation ◽  
Average Size

CaO(15%)-ZrO2nano-powders were prepared by microwave pyrolysis in a multi-model chamber at the temperature ranging from 650°C to 800°C, with the precursor processed at different reaction temperature from 0°C to 80°C by chemical co-precipitation method. XRD and SEM techniques were used to characterize the phase transition and micrograph of powders. It is found that the content of m-ZrO2phase decreased with the increasing of reaction temperature and pyrolysis temperature. The high dispersed and superfine nano-powders were obtained at the pyrolysis temperature of 750°C for 20 min at 80°C. And only cubic ZrO2phase were detected in CaO (15%)-ZrO2powders and the average size of the powders is about 41 nm.

Synthesis and Characterization of Y2O3/SiO2 Composites

2004 ◽  
Vol 59 (4-5) ◽  
pp. 281-287
Author(s):  
C. Cannas ◽  
M. Casu ◽  
M. Mainas ◽  
A. Musinu ◽  
G. Piccaluga
Keyword(s):  
Molecular Level ◽  
Precipitation Method ◽  
Synthesis And Characterization ◽  
Impregnation Method ◽  
Deposition Method ◽  
Yttrium Hydroxide ◽  
Nanocrystalline Particles ◽  
Silica Addition ◽  
Average Size

Impregnation and deposition-precipitation syntheses have been used to obtain Y2O3/SiO2 samples. In the deposition method, the urea causes the precipitation of yttrium hydroxide, which leads to the formation of yttria nanocrystalline particles in the final composites. Delaying the silica addition up to the visible muddying of the solution, a relevant formation of yttria nanocrystalline particles with average size of about 12 nm is produced. The composites obtained through the impregnation method are amorphous and contain different amounts of yttrium depending on the kind of solvent, the highest concentration being reached using ethanol. In all the samples important interactions at the molecular level among yttrium and silica are revealed, but less important in composites obtained with the deposition precipitation method.

Preparation and Characterization of Chitosan-Poly(MA-PEG400-SA) Nanoparticles as Drug Carrier

2012 ◽  
Vol 528 ◽  
pp. 39-42
Author(s):  
Dan Zhang ◽  
Fei Qiu ◽  
Yong Diao
Keyword(s):  
Aqueous Solution ◽  
Surface Charge ◽  
Drug Carrier ◽  
Drug Loading ◽  
Synthesis Conditions ◽  
Hydrophilic Drug ◽  
Ft Ir ◽  
Model Drug ◽  
Average Size

In order to prepare chitosan-based nanoparticles for drug delivery, we synthesis chitosan-poly(methacryloyl polyethylene glycol succinic acid, MA-PEG400-SA) nanoparticles in aqueous solution via template polymerization. The structure of the chitosan-poly(MA-PEG400-SA) nanoparticles was characterized by FT-IR spectra, and the particles size and surface charge were analyzed by zetasizer, respectively. The average size of chitosan-poly(MA-PEG400-SA) nanoparticles was approximate 325 nm, and the surface charge was 33mv. Using hydrophilic drug 5-FU as the model drug, the drug loading efficiency was about 6%. In the further study, we will optimize the synthesis conditions and study on the drug release properties of the nanoparticles.

scholarly journals DEVELOPMENT AND CHARACTERIZATION OF TOPICAL NANOPARTICULATE ANTIPSORIATIC POLYHERBAL CREAM

2020 ◽  
pp. 67-73
Author(s):  
SHADAB KHAN ◽  
GHAZALA MULLA ◽  
KIRAN BHISE
Keyword(s):  
Drug Loading ◽  
Lawsonia Inermis ◽  
Drug Diffusion ◽  
Cream Formulation ◽  
Diffusion Studies ◽  
Preclinical Trials ◽  
Ultraviolet Ray ◽  
Hacat Cell Lines

Objective: The lack of possible cure and associated disadvantages of allopathic medicines in the topical treatment of psoriasis has led to extensive research for anti-psoriatic activities of plant-based drugs. The present study was aimed to develop topical cream formulation containing the Nanostructured Lipid Carriers of Azadirachta indica leaves extract (AE), Lawsonia inermis leaves extract (LE) and fruit extract of Mallotus philippensis (ME) and assessing the antipsoriatic activity of prepared cream formulation. Methods: The Drug loaded NLCs were prepared via hot homogenization technique and incorporated into the water in oil (w/o) cream base that was prepared by the emulsification method. Evaluation of cream formulation included advanced preclinical trials using Rat Ultraviolet Ray-B photodermatitis and Mousetail method, anti-lipid peroxidation assay, nitric oxide scavenging activity, cytotoxicity and DNA fragmentation on HaCat cell lines to ascertain antipsoriatic potential and in vitro drug diffusion. Results: In spite of the low amount of the drug loading in NLCs their potency was much higher as displayed in Advanced Preclinical studies and cell line studies for psoriasis indicating the suitability of NLCs loaded creams for skin applications due to their various desirable effects on the skin. Occlusive properties of the prepared NLC on the skin provide an increase in drug penetration particularly via skin moisturization. The in vitro drug diffusion studies suggest the prolonged and almost complete release of AE, LE and ME from NLC based cream up to 24 h that was found to be 81.24±0.51%, 74.31±0.25% and 70.43±0.78% respectively. The literature survey supports the novelty of such topical anti-psoriatic polyherbal nanoparticulate cream. Conclusion: It can be concluded that the AE, LE and ME loaded NLC based cream can be used for prolonged topical delivery of drugs for the management of Psoriasis.

Studying the Temperature Effect on the Magnetic Behavior of Fe3O4 Water Based Ferrofluid

2017 ◽  
Vol 744 ◽  
pp. 468-472
Author(s):  
Ahmad Amirabadizadeh ◽  
Amir Zelati ◽  
Zahra Lotfollahi
Keyword(s):  
Magnetic Measurements ◽  
Spherical Shape ◽  
Magnetic Behavior ◽  
Precipitation Method ◽  
Magnetite Nanoparticle ◽  
Water Based ◽  
Magnetic Softness ◽  
Co Precipitation ◽  
Average Size

In this study, Iron Oxide (Fe3O4) nanoparticles water based ferrofluid, was synthesized by co-precipitation method. XRD was used to study the structural characterization of the sample and to measure the size of the crystallites (using Scherrer equation). TEM was utilized to examine the shape, the size distribution and the morphology of the nanoparticles. VSM was carried out to measure the magnetic properties (like Mr, Ms and Hc) of the Fe3O4 (magnetite) nanoparticle and magnetite ferrofluid at 80 and 300 K. The results indicate that the average size of the magnetite roughly spherical shape nanoparticles is 13nm. The VSM results show that the magnetite ferrofluid contains single domain magnetic nanoparticles with superparamagnetic behavior. In addition, the magnetic measurements demonstrate that with decreasing the temperature of the ferrofluid, its magnetic softness decreases while its anisotropy increases.

Exploring the characterization of Ni doped MgO nanoparticles using co-precipitation method

2020 ◽  
Vol 3 (1) ◽  
pp. 30-33
Author(s):  
Muthulakshmi M ◽  
Madhumitha G
Keyword(s):  
Magnesium Oxide ◽  
Analytical Techniques ◽  
Nickel Chloride ◽  
Precipitation Method ◽  
Crystalline Powder ◽  
High Melting Point ◽  
Design Synthesis ◽  
Mgo Nanoparticles ◽  
Co Precipitation

Nanotechnology is a field of applied science focused on design, synthesis and characterization of nanomaterials. The nickel and magnesium have improved their applications in transparent electrodes and nano electronics. In addition, magnesium oxide has moisture resistance and high melting point properties. In the present work has been carried out in the development of green crystalline powder of nickel doped magnesium oxide nanoparticles by Co-precipitation method, from the mixture of nickel chloride and magnesium chloride with KOH as solvent. From the XRD results, crystalline size of the particle can be observed. Spherical structure of Ni doped MgO nanoparticles were indicated by SEM results and powdered composition of samples were obtained from FTIR. EDAX represents the peak composition of the nanoparticle. The above analytical techniques have confirmed that the Ni doped MgO nanoparticles obtained from the mixture of NiCl2 and MgCl2.

Structural and morphological characterization of CdS nanoparticles

2020 ◽  
Vol 10 ◽  
Author(s):  
Manish Dwivedi ◽  
Vijay Tripathi ◽  
Dhruv Kumar ◽  
Dwijendra K. Gupta
Keyword(s):  
Blue Shift ◽  
Chemical Precipitation ◽  
Morphological Characterization ◽  
Precipitation Method ◽  
Cds Nanoparticles ◽  
Cubic Phase ◽  
Simple Chemical ◽  
Xrd Patterns ◽  
Average Size ◽  
Physical Tools

Aims: CdS nanoparticles are an attractive material having application in various field like as pigment in paints, biotag for bioimaging and many more optoelectronic as well as biological applications. Present study aims to synthesize and characterize the CdS nanoparticles to make it applicable in different areas Objectives: Preparation CdS nanoparticles by using simple and facile chemical methods and further physical and structural characterization using various physical tools Methods: In present work CdS nanoparticles has been synthesized by using rationally simple chemical precipitation method with some modi-fication on temperature and incubation time in existed methods. Characterizations were done by employing XRD, SEM, TEM, AFM tech-niques Results: Simple chemical method produces the CdS nanoparticles with the size about 100-200 nm in length and 5-10 nm in diameter. The SEM studies show that the CdS nanoparticles can agglomerate and form a continuous network like structure. The X-ray diffraction (XRD) measurements show the single-phase formation of CdS nanoparticles with the structure of cubic phase, and the broadening of XRD patterns indicates that the prepared samples are nanostructured. Our analysis on CdS nanoparticles by using transmission electron microscope and atomic force microscope (AFM) revealed that the nanoparticles form both spherical and nearly rod shaped with the average size applicable for biotagging. UV-Vis spectroscopic analysis reveals blue shift in the absorption peak probably caused by quantum confinement Conclusion: The observed CdS nanoparticles were appeared yellow in color. The XRD pattern of the CdS nanoparticles showed that the materials were of nanometric sized regime with a predominantly cubic phase along with the rod and round morphology. The study and char-acterization of CdS nanoparticles will bring us a new approach to understand biological problem by tagging nanoparticles with biomolecules and further suggests that the CdS nanoparticles formulate it more suitable biocompatible nanomaterial for biotagging and bioimaging

scholarly journals Microscopic Image Segmentation and Morphological Characterization of Novel Chitosan/Silica Nanoparticle/Nisin Films Using Antimicrobial Technique for Blueberry Preservation

Membranes ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 303
Author(s):  
Rokayya Sami ◽  
Schahrazad Soltane ◽  
Mahmoud Helal
Keyword(s):  
Ph Value ◽  
Silica Nanoparticle ◽  
Morphological Characterization ◽  
Aerobic Bacteria ◽  
Nano Materials ◽  
Elongation At Break ◽  
Stable Suspension ◽  
Average Size ◽  
Material Ductility

In the current work, the characterization of novel chitosan/silica nanoparticle/nisin films with the addition of nisin as an antimicrobial technique for blueberry preservation during storage is investigated. Chitosan/Silica Nanoparticle/N (CH-SN-N) films presented a stable suspension as the surface loads (45.9 mV) and the distribution was considered broad (0.62). The result shows that the pH value was increased gradually with the addition of nisin to 4.12, while the turbidity was the highest at 0.39. The content of the insoluble matter and contact angle were the highest for the Chitosan/Silica Nanoparticle (CH-SN) film at 5.68%. The use of nano-materials in chitosan films decreased the material ductility, reduced the tensile strength and elongation-at-break of the membrane. The coated blueberries with Chitosan/Silica Nanoparticle/N films reported the lowest microbial contamination counts at 2.82 log CFU/g followed by Chitosan/Silica Nanoparticle at 3.73 and 3.58 log CFU/g for the aerobic bacteria, molds, and yeasts population, respectively. It was observed that (CH) film extracted 94 regions with an average size of 449.10, at the same time (CH-SN) film extracted 169 regions with an average size of 130.53. The (CH-SN-N) film presented the best result at 5.19%. It could be observed that the size of the total region of the fruit for the (CH) case was the smallest (1663 pixels), which implied that the fruit lost moisture content. As a conclusion, (CH-SN-N) film is recommended for blueberry preservation to prolong the shelf-life during storage.

Annealing effects on phase transformation and powder microstructure of nanocrystalline zirconia polymorphs

1999 ◽  
Vol 14 (1) ◽  
pp. 90-96 ◽  
Author(s):  
R. Ramamoorthy ◽  
S. Ramasamy ◽  
D. Sundararaman
Keyword(s):  
Monoclinic Phase ◽  
Lattice Strain ◽  
Dopant Concentration ◽  
Precipitation Method ◽  
Strain Effect ◽  
Volume Percentage ◽  
Annealing Temperatures ◽  
Annealing Effects ◽  
Nanocrystalline Zirconia ◽  
Average Size

Nanocrystalline zirconia powders in pure form and doped with yttria and calcia were prepared by the precipitation method. In the as-prepared condition, all the doped samples show only monoclinic phase, independent of the dopants and dopant concentration. On annealing the powders at 400 °C and above, in the case of 3 and 6 mol% Y2O3 stabilized ZrO2 (3YSZ and 6YSZ), the monoclinic phase transforms to tetragonal and cubic phases, respectively, whereas in 3 and 6 mol% CaO stabilized ZrO2 (3CSZ and 6CSZ), the volume percentage of the monoclinic phase gradually decreases up to the annealing temperature of about 1000 °C and then increases for higher annealing temperatures. The presence of monoclinic phase in the as-prepared samples of doped zirconia has been attributed to the lattice strain effect which results in the less symmetric lattice. For the annealing temperatures below 1000 °C, the phenomenon of partial stabilization of the tetragonal phase in 3CSZ and 6CSZ can be explained in terms of the grain size effect. High resolution transmission electron microscopy (HRTEM) observations reveal the lattice strain structure in the as-prepared materials. The particles are found to be a tightly bound aggregate of small crystallites with average size of 10 nm. The morphology of the particles is observed to be dependent on the dopants and dopant concentration.

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