On the Drug-Loading Capacity of Pectin Powder for Direct Compression

Inorganic nanoparticles are gaining increasing attention as drug carriers because they respond to external physical stimuli, allowing to combine therapy with diagnosis. Their drawback is a low drug loading capacity,...

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Cancer Nanomedicines Stabilized by π-π Stacking between Heterodimeric Prodrugs Enable Exceptionally High Drug Loading Capacity and Safer Delivery of Drug Combinations

Theranostics ◽

10.7150/thno.20028 ◽

2017 ◽

Vol 7 (15) ◽

pp. 3638-3652 ◽

Cited By ~ 42

Author(s):

Hangxiang Wang ◽

Jianmei Chen ◽

Chang Xu ◽

Linlin Shi ◽

Munire Tayier ◽

...

Keyword(s):

Drug Loading ◽

Drug Combinations ◽

Loading Capacity ◽

High Drug ◽

Π Stacking ◽

High Drug Loading

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Synthesis of pH-Sensitive and Self-Fluorescent Polymeric Micelles Derived From Rosin and Vegetable Oils via ATRP

Frontiers in Bioengineering and Biotechnology ◽

10.3389/fbioe.2021.753808 ◽

2021 ◽

Vol 9 ◽

Author(s):

Juan Yu ◽

Chaoqun Xu ◽

Chuanwei Lu ◽

Qian Liu ◽

Jifu Wang ◽

...

Keyword(s):

Aqueous Solution ◽

Vegetable Oils ◽

Renewable Resources ◽

Polymeric Micelles ◽

Drug Loading ◽

Dehydroabietic Acid ◽

Great Promise ◽

Loading Capacity ◽

Carboxylic Groups ◽

Ph Dependent

Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.

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Synthesis and Characterization of Stearic Acid-Beclomethasone Dipropionate Conjugates with the Potential for Improving Loading Capacity in Lipid-based Nanoparticles

10.26434/chemrxiv.13520156 ◽

2021 ◽

Author(s):

Shishuai Dang ◽

Zhengwei Huang ◽

Ying Huang ◽

Xin Pan ◽

Chuanbin Wu

Keyword(s):

Drug Delivery ◽

Stearic Acid ◽

Beclomethasone Dipropionate ◽

Drug Loading ◽

Pulmonary Delivery ◽

Dynamics Simulation ◽

Loading Capacity ◽

Technology Platform ◽

New Type ◽

Model Drug

<p>Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug delivery system, which have been gradually shown broad prospects in pulmonary drug delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is the low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low lipophilicity drugs in LBNs, for the therapy of lung diseases. A proof-of-concept was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated by molecular dynamics simulation. It is expected that the drug loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.</p>

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Layered Double Hydroxide Assemblies with Controllable Drug Loading Capacity and Release Behavior as well as Stabilized Layer-by-Layer Polymer Multilayers

ACS Applied Materials & Interfaces ◽

10.1021/acsami.5b04569 ◽

2015 ◽

Vol 7 (34) ◽

pp. 19104-19111 ◽

Cited By ~ 37

Author(s):

Fengzhu Lv ◽

Linan Xu ◽

Yihe Zhang ◽

Zilin Meng

Keyword(s):

Layered Double Hydroxide ◽

Drug Loading ◽

Loading Capacity ◽

Layer By Layer ◽

Release Behavior ◽

Double Hydroxide

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Synthesis and characterization of magnetic chitosan microspheres for drug delivery

RSC Advances ◽

10.1039/c9ra10792d ◽

2020 ◽

Vol 10 (12) ◽

pp. 7163-7169

Author(s):

Xin Li ◽

Danlin Zeng ◽

Ping Ke ◽

Guanghui Wang ◽

Dengke Zhang

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Drug Loading ◽

Synthesis And Characterization ◽

Loading Capacity ◽

Microemulsion Polymerization ◽

Magnetic Microsphere ◽

Magnetic Chitosan Microspheres ◽

Protein Drug Delivery

A novel magnetic microsphere was prepared by the simple microemulsion polymerization for protein drug delivery systems. This magnetic microsphere exhibited good magnetism and superior drug loading capacity and evident sustained-release performance.

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Effect of Modified Hydroxypropyl Tapioca Starch and Percentage of Drug Loading on Physical Property of Paracetamol Tablet

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.859.3 ◽

2020 ◽

Vol 859 ◽

pp. 3-8

Author(s):

Vipaluk Patomchaiviwat ◽

Sontaya Limmatvapirat ◽

Chaisai Sirisapaya ◽

Rohanee Kolae ◽

Kulmanee Anantakul ◽

...

Keyword(s):

Drug Loading ◽

Physical Property ◽

High Hardness ◽

Direct Compression ◽

Compression Method ◽

Disintegration Time ◽

Tapioca Starch ◽

Drug Concentrations ◽

Model Drug ◽

Better Than

The objective of this study was to investigate the effect of modified hydroxypropyl tapioca starch (HPTS) and % drug loading on physical property of tablet. Paracetamol was used as model drug because of its poor compressibility. The filler ability of modified HPTS such as hydroxyl propyl oxidized tapioca starch (HPOTS), hydroxyl propyl crosslinked tapioca starch (HPCTS) and pregelatinized tapioca starch (PTS) were evaluated and compared with the commercial starch (Starch 1500®). Tablets were prepared by direct compression method and the percent drug loading were 15, 30, 45, 60, 75%. For modified HPTS, the hardness of the tablets tended to decrease when the concentration of paracetamol increased. At drug concentrations of 15-30%, HPOTS exhibited good performance of tablet as indicated by the high hardness, low friability and acceptable disintegration time. The obtained results were better than HPTS and comparable to Starch 1500®. Moreover, the results revealed that tablet containing PTS provided the highest hardness and prolonged disintegration time (>30 min) while tablet containing HPCTS showed rapid disintegration time (<2 min). Therefore, modified HPTS disclosed promising properties for application as tablet filler

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