Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture

Endocrinology ◽  
1992 ◽  
Vol 130 (4) ◽  
pp. 2031-2036 ◽  
Author(s):  
O. Shinohara
Keyword(s):  
Cell Differentiation ◽  
Precursor Cell ◽  
Serum Free ◽  
Endothelin 1 ◽  
Adipocyte Precursor

Endothelin-1 suppression of rat adipocyte precursor cell differentiation in serum-free culture.

Endocrinology ◽  
1992 ◽  
Vol 130 (4) ◽  
pp. 2031-2036
Author(s):  
O Shinohara ◽  
Y Murata ◽  
M Shimizu
Keyword(s):  
Cell Differentiation ◽  
Precursor Cell ◽  
Serum Free ◽  
Endothelin 1 ◽  
Adipocyte Precursor

scholarly journals Search for the adipocyte precursor cell and factors that promote its differentiation.

1980 ◽  
Vol 21 (6) ◽  
pp. 657-670
Author(s):  
G J Hausman ◽  
D R Campion ◽  
R J Martin
Keyword(s):  
Precursor Cell ◽  
Adipocyte Precursor

scholarly journals Inhibition of phosphodiesterase‐4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

2013 ◽  
Vol 5 (12) ◽  
pp. 1918-1934 ◽  
Author(s):  
Yasir A. Syed ◽  
Alexandra Baer ◽  
Matthias P. Hofer ◽  
Ginez A. González ◽  
Jon Rundle ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Precursor Cell ◽  
Oligodendrocyte Precursor Cell ◽  
Phosphodiesterase 4 ◽  
Oligodendrocyte Precursor

A serum-free media formulation for cultured meat production supports bovine satellite cell differentiation in the absence of serum starvation

Nature Food ◽  
2022 ◽  
Author(s):  
Tobias Messmer ◽  
Iva Klevernic ◽  
Carolina Furquim ◽  
Ekaterina Ovchinnikova ◽  
Arin Dogan ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Satellite Cell ◽  
Serum Starvation ◽  
Meat Production ◽  
Serum Free ◽  
Media Formulation ◽  
Cultured Meat ◽  
Free Media

The scaleless wings mutant in Bombyx mori is associated with a lack of scale precursor cell differentiation followed by excessive apoptosis

2006 ◽  
Vol 216 (11) ◽  
pp. 721-726 ◽  
Author(s):  
Qing-Xiang Zhou ◽  
Yi-Nü Li ◽  
Xing-Jia Shen ◽  
Yong-Zhu Yi ◽  
Yao-Zhou Zhang ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Bombyx Mori ◽  
Precursor Cell

scholarly journals Different profiles of Ca2+ responses to endothelin-1 and PDGF in liver myofibroblasts during the process of cell differentiation

2007 ◽  
Vol 151 (6) ◽  
pp. 816-827 ◽  
Author(s):  
N Kojima ◽  
M Hori ◽  
T Murata ◽  
Y Morizane ◽  
H Ozaki
Keyword(s):  
Cell Differentiation ◽  
Endothelin 1 ◽  
Liver Myofibroblasts

Flow Cytometry and Lineage Tracing Study for Identification of Adipocyte Precursor Cell (APC) Populations

2018 ◽  
pp. 111-121 ◽  
Author(s):  
Ju Hee Lee ◽  
Azadeh Yeganeh ◽  
Hisato Konoeda ◽  
Joon Ho Moon ◽  
Hoon-Ki Sung
Keyword(s):  
Flow Cytometry ◽  
Precursor Cell ◽  
Lineage Tracing ◽  
Adipocyte Precursor

SIAMESE, a gene controlling the endoreduplication cell cycle in Arabidopsis thaliana trichomes

Development ◽  
2000 ◽  
Vol 127 (18) ◽  
pp. 3931-3940 ◽  
Author(s):  
J.D. Walker ◽  
D.G. Oppenheimer ◽  
J. Concienne ◽  
J.C. Larkin
Keyword(s):  
Cell Cycle ◽  
Cell Differentiation ◽  
Genetic Locus ◽  
Precursor Cell ◽  
Recessive Mutation ◽  
Wild Type ◽  
Normal Morphology ◽  
Cell Divisions ◽  
Nondividing Cell ◽  
Scanning Electron

Cell differentiation is generally tightly coordinated with the cell cycle, typically resulting in a nondividing cell with a unique differentiated morphology. The unicellular trichomes of Arabidopsis are a well-established model for the study of plant cell differentiation. Here, we describe a new genetic locus, SIAMESE (SIM), required for coordinating cell division and cell differentiation during the development of Arabidopsis trichomes (epidermal hairs). A recessive mutation in the sim locus on chromosome 5 results in clusters of adjacent trichomes that appeared to be morphologically identical ‘twins’. Upon closer inspection, the sim mutant was found to produce multicellular trichomes in contrast to the unicellular trichomes produced by wild-type (WT) plants. Mutant trichomes consisting of up to 15 cells have been observed. Scanning electron microscopy of developing sim trichomes suggests that the cell divisions occur very early in the development of mutant trichomes. WT trichome nuclei continue to replicate their DNA after mitosis and cytokinesis have ceased, and as a consequence have a DNA content much greater than 2C. This phenomenon is known as endoreduplication. Individual nuclei of sim trichomes have a reduced level of endoreduplication relative to WT trichome nuclei. Endoreduplication is also reduced in dark-grown sim hypocotyls relative to WT, but not in light-grown hypocotyls. Double mutants of sim with either of two other mutants affecting endoreduplication, triptychon (try) and glabra3 (gl3) are consistent with a function for SIM in endoreduplication. SIM may function as a repressor of mitosis in the endoreduplication cell cycle. Additionally, the relatively normal morphology of multicellular sim trichomes indicates that trichome morphogenesis can occur relatively normally even when the trichome precursor cell continues to divide. The sim mutant phenotype also has implications for the evolution of multicellular trichomes.

Role of cyclic nucleotides in the regulation of endothelin-1 production by human endothelial cells

1994 ◽  
Vol 266 (3) ◽  
pp. H944-H951
Author(s):  
D. J. Stewart ◽  
P. Cernacek ◽  
F. Mohamed ◽  
D. Blais ◽  
K. Cianflone ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cyclic Nucleotides ◽  
Umbilical Vein ◽  
Calf Serum ◽  
Significant Shift ◽  
Serum Free ◽  
Endothelin 1 ◽  
Physiological Importance ◽  
Serum Free Conditions

The regulation of endothelin-1 (ET-1) production by endothelial cells is likely of crucial physiological importance in the maintenance of vascular homeostasis. The aim of the present study was to explore the possible role of cyclic nucleotides in the control of ET-1 production in human umbilical vein endothelial cells (HUVEC). ET-1 release was determined by measuring levels of immunoreactive ET-1 in HUVEC-conditioned media after 6-h incubations. In the presence of 10% fetal calf serum (FCS) there was a threefold increase in ET-1 release compared with serum-free conditions (1.96 +/- 0.17 vs. 0.56 +/- 0.06 pg/micrograms protein), respectively. Inhibition of protein kinase (PK) C using staurosporine (10 nM) reduced basal ET-1 release by approximately 50% and completely prevented the response to FCS. In contrast, the addition of other PK inhibitors had little effect on basal or serum-stimulated ET-1 release at the concentrations used. N6,2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (DBcAMP) produced significant alterations in ET-1 release depending on the basal level of production. Under serum-free conditions of low basal ET-1 production, DBcAMP increased ET-1 release by 68 +/- 22% but only at the highest concentration studied (1 mM). The dose-response relationship for DBcAMP was potentiated by KT-5720 (0.1 microM), an inhibitor of PKA, with a significant shift to 10-fold lower concentrations, whereas it was blocked by KT-5823 (4 microM), which can inhibit PKG.(ABSTRACT TRUNCATED AT 250 WORDS)

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