A Quantitative Immunocytochemical Study of the Luteinizing Hormone and Follicle-Stimulating Hormone Cells in the Adenohypophysis of Adult Male Rats and Adult Female Rats throughout the Estrous Cycle*

Endocrinology ◽  
1983 ◽  
Vol 113 (3) ◽  
pp. 970-984 ◽  
Author(s):  
M. O. DADA ◽  
G. T. CAMPBELL ◽  
C. A. BLAKE
Keyword(s):  
Luteinizing Hormone ◽  
Estrous Cycle ◽  
Adult Female ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Female Rats ◽  
Male Rats ◽  
Immunocytochemical Study ◽  
Stimulating Hormone

EFFECTS OF FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE ON PLASMA TESTOSTERONE LEVELS IN HYPOPHYSECTOMIZED AND IN INTACT IMMATURE AND ADULT MALE RATS

1974 ◽  
Vol 61 (2) ◽  
pp. 193-198 ◽  
Author(s):  
S. EL SAFOURY ◽  
A. BARTKE
Keyword(s):  
Luteinizing Hormone ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Adult Rats ◽  
Testosterone Levels ◽  
Hypophysectomized Rats ◽  
Stimulating Hormone

SUMMARY The effects of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on plasma testosterone levels were examined in hypophysectomized and in intact immature and adult male rats. The animals were injected with saline, LH, FSH, or both gonadotrophins twice daily for 3·5 days and were killed 3 h after the last injection. Plasma testosterone levels were measured by radioimmunoassay. In immature hypophysectomized rats, plasma testosterone levels were not changed by treatment with LH, FSH or LH plus FSH. The weight of the testes and of the seminal vesicles was increased only in animals injected with both LH and FSH. In adult hypophysectomized rats, LH caused the expected increase in plasma testosterone levels, while FSH injected alone had no effect. Plasma testosterone levels in rats treated with 5 μg LH and 20 μg FSH were significantly greater than those in animals given 5 μg LH alone. However, the same dose of FSH did not potentiate the action of 25 μg LH on plasma testosterone levels. In adult hypophysectomized rats the weight of testes was not affected by any of the treatments. The weight of the seminal vesicles was increased by the higher dose of LH and addition of FSH caused no further increase. In intact immature and adult rats plasma testosterone levels and the weight of testes were not changed by any of the treatments. Seminal vesicle weight was increased only in adult rats treated with the higher dose of LH together with FSH. The results demonstrate that FSH potentiates the action of low doses of LH on plasma testosterone levels in adult hypophysectomized rats and suggest that FSH may be involved in the regulation of androgen secretion by the rat testis.

OBSERVATIONS ON A DITHIOCARBAMOYLHYDRAZINE AS AN INHIBITOR OF PITUITARY GONADOTROPHIC ACTIVITY

1963 ◽  
Vol 26 (3) ◽  
pp. 425-436 ◽  
Author(s):  
P. S. BROWN
Keyword(s):  
Adult Female ◽  
General Condition ◽  
Follicle Stimulating Hormone ◽  
Specific Effect ◽  
Female Rats ◽  
Male Rats ◽  
Pituitary Glands ◽  
Rats And Mice ◽  
Intact Rats ◽  
Stimulating Hormone

SUMMARY A dithiocarbamoylhydrazine (ICI 33828) was injected s.c. into intact rats and mice. It usually caused a reduction in weight of the uterus or of the accessory organs in the male, but less commonly of the gonads. As little as 0·5 mg. daily for 4 days caused significant effects in adult female rats, while half this dose on alternate days retarded maturation in male rats. ICI 33828 was injected with exogenous gonadotrophin in three systems of assay and in some cases it modified the response to the gonadotrophin. This may not be due to a specific effect at the gonadal level but either to suppression of endogenous gonadotrophins in the test animals or to the effect of ICI 33828 on their general condition. Pituitary glands from male rats treated with ICI 33828 were assayed for follicle stimulating hormone (FSH) and found to contain significantly less than glands from control rats. This suggests that ICI 33828 acts by reducing the formation of pituitary gonadotrophin.

PITUITARY SECRETION OF PROLACTIN, LUTEINIZING HORMONE AND FOLLICLESTIMULATING HORMONE IN ADULT FEMALE RATS TREATED NEONATALLY WITH OESTROGEN

1973 ◽  
Vol 59 (3) ◽  
pp. 599-604 ◽  
Author(s):  
HIROSHI NAGASAWA ◽  
REIKO YANAI ◽  
SAKAE KIKUYAMA ◽  
JUNICHI MORI
Keyword(s):  
Luteinizing Hormone ◽  
Serum Level ◽  
Adult Female ◽  
Follicle Stimulating Hormone ◽  
Female Rats ◽  
Female Rat ◽  
Pituitary Secretion ◽  
Stimulating Hormone

SUMMARY The serum and pituitary levels of prolactin, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined by radioimmunoassay in adult female rats treated neonatally with oestrogen and were compared with levels in normal cyclic rats at 90, 150 and/or 180 days of age. The serum level of prolactin was significantly higher and its pituitary content and concentration were lower in oestrogenized rats than in control rats at early prooestrus and on the 2nd day of dioestrus. The level of LH in the serum of oestrogenized rats was similar to the level in control rats at pro-oestrus and was higher than that of the controls at dioestrus. Pituitary levels of LH were lower in oestrogenized rats than in control rats at both pro-oestrus and dioestrus. The serum and pituitary levels of FSH in the oestrogenized rats were intermediate between the values found at dioestrus and at pro-oestrus in the controls. The results demonstrate that the pituitary of the neonatally oestrogenized female rat constantly secretes considerable amounts of these hormones.

SHORT-TERM EFFECTS OF CASTRATION AND STARVATION UPON PITUITARY AND SERUM LEVELS OF LUTEINIZING HORMONE AND FOLLICLE STIMULATING HORMONE IN MALE RATS

1972 ◽  
Vol 70 (4) ◽  
pp. 665-675 ◽  
Author(s):  
Allen W. Root ◽  
R. David Russ
Keyword(s):  
Luteinizing Hormone ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Serum Levels ◽  
Male Rats ◽  
Serum Concentrations ◽  
Short Term ◽  
Serum Lh ◽  
Total Starvation ◽  
Stimulating Hormone

ABSTRACT Serum and pituitary levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured by radioimmunoassay in intact and castrated juvenile (21 days) and adult male rats. The effect of total starvation upon the gonadotrophin response to castration was also investigated in adult animals. In rats castrated at 21 days of age, serum and pituitary levels of LH were elevated by 7 days and increased progressively for 4 weeks. Serum concentrations of FSH also increased within 7 days and remained stable thereafter. Pituitary FSH levels initially declined and then increased. In adult animals serum LH and FSH concentrations increased after castration. Pituitary LH values also increased, while FSH levels remained stable for 14 days after operation. Serum FSH concentrations were consistently decreased in starved-intact animals. Starvation partially inhibited castration-induced release of LH without affecting pituitary LH or FSH synthesis or FSH release.

scholarly journals Concurrent Pulsatile Secretion of Luteinizing Hormone and Follicle-Stimulating Hormone during Different Phases of the Estrous Cycle and Anestrus in Beagle Bitches

1999 ◽  
Vol 60 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Hans S. Kooistra ◽  
Auke C. Okkens ◽  
Mart M. Bevers ◽  
Corrie Popp-Snijders ◽  
Bas van Haaften ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Estrous Cycle ◽  
Follicle Stimulating Hormone ◽  
Pulsatile Secretion ◽  
Stimulating Hormone
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