EFFECTS OF FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE ON PLASMA TESTOSTERONE LEVELS IN HYPOPHYSECTOMIZED AND IN INTACT IMMATURE AND ADULT MALE RATS

1974 ◽  
Vol 61 (2) ◽  
pp. 193-198 ◽  
Author(s):  
S. EL SAFOURY ◽  
A. BARTKE
Keyword(s):  
Luteinizing Hormone ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Plasma Testosterone ◽  
Adult Rats ◽  
Testosterone Levels ◽  
Hypophysectomized Rats ◽  
Stimulating Hormone

SUMMARY The effects of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) on plasma testosterone levels were examined in hypophysectomized and in intact immature and adult male rats. The animals were injected with saline, LH, FSH, or both gonadotrophins twice daily for 3·5 days and were killed 3 h after the last injection. Plasma testosterone levels were measured by radioimmunoassay. In immature hypophysectomized rats, plasma testosterone levels were not changed by treatment with LH, FSH or LH plus FSH. The weight of the testes and of the seminal vesicles was increased only in animals injected with both LH and FSH. In adult hypophysectomized rats, LH caused the expected increase in plasma testosterone levels, while FSH injected alone had no effect. Plasma testosterone levels in rats treated with 5 μg LH and 20 μg FSH were significantly greater than those in animals given 5 μg LH alone. However, the same dose of FSH did not potentiate the action of 25 μg LH on plasma testosterone levels. In adult hypophysectomized rats the weight of testes was not affected by any of the treatments. The weight of the seminal vesicles was increased by the higher dose of LH and addition of FSH caused no further increase. In intact immature and adult rats plasma testosterone levels and the weight of testes were not changed by any of the treatments. Seminal vesicle weight was increased only in adult rats treated with the higher dose of LH together with FSH. The results demonstrate that FSH potentiates the action of low doses of LH on plasma testosterone levels in adult hypophysectomized rats and suggest that FSH may be involved in the regulation of androgen secretion by the rat testis.

SHORT-TERM EFFECTS OF CASTRATION AND STARVATION UPON PITUITARY AND SERUM LEVELS OF LUTEINIZING HORMONE AND FOLLICLE STIMULATING HORMONE IN MALE RATS

1972 ◽  
Vol 70 (4) ◽  
pp. 665-675 ◽  
Author(s):  
Allen W. Root ◽  
R. David Russ
Keyword(s):  
Luteinizing Hormone ◽  
Adult Male ◽  
Follicle Stimulating Hormone ◽  
Serum Levels ◽  
Male Rats ◽  
Serum Concentrations ◽  
Short Term ◽  
Serum Lh ◽  
Total Starvation ◽  
Stimulating Hormone

ABSTRACT Serum and pituitary levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were measured by radioimmunoassay in intact and castrated juvenile (21 days) and adult male rats. The effect of total starvation upon the gonadotrophin response to castration was also investigated in adult animals. In rats castrated at 21 days of age, serum and pituitary levels of LH were elevated by 7 days and increased progressively for 4 weeks. Serum concentrations of FSH also increased within 7 days and remained stable thereafter. Pituitary FSH levels initially declined and then increased. In adult animals serum LH and FSH concentrations increased after castration. Pituitary LH values also increased, while FSH levels remained stable for 14 days after operation. Serum FSH concentrations were consistently decreased in starved-intact animals. Starvation partially inhibited castration-induced release of LH without affecting pituitary LH or FSH synthesis or FSH release.

Termination of the peripubertal FSH increase in male rats

1992 ◽  
Vol 262 (2) ◽  
pp. E179-E184
Author(s):  
S. J. Nazian ◽  
D. F. Cameron
Keyword(s):  
Luteinizing Hormone ◽  
Leydig Cells ◽  
Interstitial Fluid ◽  
Follicle Stimulating Hormone ◽  
Serum Testosterone ◽  
Seminal Vesicles ◽  
Male Rats ◽  
Serum Luteinizing Hormone ◽  
Stimulating Hormone

To determine if the pubertal testosterone rise plays a role in the termination of the peripubertal follicle-stimulating hormone (FSH) increase, male rats were injected with ethylene dimethanesulfonate (EDS) at 40 days of age to eradicate the Leydig cells just before the onset of the testosterone rise. Rats were decapitated at weekly intervals from age 26 to 96 days. Compared with vehicle-injected controls, EDS treatment resulted in a delay in the peripubertal increase in the relative weights of prostates and seminal vesicles of approximately 2 wk. Serum testosterone remained at pretreatment levels for 1 wk postinjection. Testicular interstitial fluid testosterone remained at pretreatment concentrations for considerably longer and was significantly lower than controls for 2 wk postinjection. EDS treatment resulted in serum FSH levels that were elevated by 1 wk postinjection. They remained significantly higher than controls until 96 days of age. Compared with controls, serum alpha-inhibin was elevated after EDS as was serum luteinizing hormone. These results suggest that the pubertal testosterone increase plays an important role in terminating the peripubertal FSH rise.

Studies on Spermatogenesis in Rats. III. Effects of Hormonal Treatment on Differentiation Kinetics of the Spermatogenic Cycle in Regressed Hypophysectomized Rats

1971 ◽  
Vol 49 (7) ◽  
pp. 768-775 ◽  
Author(s):  
V. L. W. Go ◽  
R. G. Vernon ◽  
I. B. Fritz
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Hormonal Treatment ◽  
Testicular Function ◽  
Carnitine Acetyltransferase ◽  
Hormonal Replacement ◽  
Hypophysectomized Rats ◽  
Kinetics Of ◽  
Stimulating Hormone

The general hormonal requirements for the restoration of spermatogenesis in regressed hypophysectomized rats were investigated. With the aid of the Staput fractionation technique, it was established that thymidine-3H was readily incorporated into spermatogonia and resting spermatocytes. Labeled cells did not progress to form appreciable numbers of primary spermatocytes or spermatids in the absence of hormonal replacement. The inhibition of formation of pachytene primary spermatocytes in hypophysectomized rats was overcome by administration of follicle-stimulating hormone (FSH), luteinizing hormone (LH), or testosterone, but a combination of either FSH plus LH, or FSH plus testosterone, was required for the progression of pachytene primary spermatocytes to spermatids and spermatozoa. Carnitine acetyltransferase (CAT) measurements in testes from various groups of animals provided ancillary evidence consistent with the conclusion that either FSH, LH, or testosterone was required for the normal restoration of pachytene-diplotene spermatocyte formation. However, one or more additional blocks in spermatogenesis existed in hypophysectomized animals, since elevation of depressed testicular CAT levels in hypophysectomized rats to normal levels required FSH plus LH, or FSH plus testosterone. Cortisone and thyroxin treatment had no measurable effects on testicular function in hypophysectomized rats.

Plasma Testosterone, Luteinizing Hormone and Follicle-Stimulating Hormone one Day after Vasectomy

Andrologia ◽  
2009 ◽  
Vol 11 (4) ◽  
pp. 294-296 ◽  
Author(s):  
R.E. JOHNSONBAUGH ◽  
L.P. GEORGES ◽  
C.L. CZERWINSKI ◽  
M. EDSON
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Plasma Testosterone ◽  
Stimulating Hormone
Sign in / Sign up

Export Citation Format

Share Document