scholarly journals Transient Expression of c-erbAβ1 Messenger Ribonucleic Acid andβ 1 Thyroid Hormone Receptor Early in Adipogenesis of Ob 17 Cells*

Endocrinology ◽  
1999 ◽  
Vol 140 (7) ◽  
pp. 2983-2990 ◽  
Author(s):  
Alexandra Dace ◽  
Gaiane Sarkissian ◽  
Laetitia Schneider ◽  
Claire Martin-El Yazidi ◽  
Jeannine Bonne ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Transient Expression ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Messenger Ribonucleic Acid

Thyroid hormone receptor messenger ribonucleic acid in human granulosa and ovarian stromal cells

1994 ◽  
Vol 62 (3) ◽  
pp. 531-534 ◽  
Author(s):  
Anthony N. Wakim ◽  
William R. Paljug ◽  
Katherine M. Jasnosz ◽  
Nawar Alhakim ◽  
Anne B. Brown ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Stromal Cells ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Messenger Ribonucleic Acid

Prolonged Fasting Reduces Rat Hepaticβ1 Thyroid Hormone Receptor Protein without Changing the Level of Its Messenger Ribonucleic Acid*

Endocrinology ◽  
1991 ◽  
Vol 129 (6) ◽  
pp. 2881-2885 ◽  
Author(s):  
JAMES T. LANE ◽  
MADAN GODBOLE ◽  
KEVIN A. STRAIT ◽  
HAROLD L. SCHWARTZ ◽  
JACK H. OPPENHEIMER
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Protein ◽  
Prolonged Fasting ◽  
Messenger Ribonucleic Acid

scholarly journals Multiple Messenger Ribonucleic Acid Variants Regulate Cell-Specific Expression of Human Thyroid Hormone Receptor β1

2004 ◽  
Vol 18 (7) ◽  
pp. 1631-1642 ◽  
Author(s):  
Sarah Frankton ◽  
Clare B. Harvey ◽  
Lisa M. Gleason ◽  
Abdessamad Fadel ◽  
Graham R. Williams
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Human Thyroid ◽  
Specific Expression ◽  
Messenger Ribonucleic Acid

scholarly journals Connexin40 Messenger Ribonucleic Acid Is Positively Regulated by Thyroid Hormone (TH) Acting in Cardiac Atria via the TH Receptor

Endocrinology ◽  
2008 ◽  
Vol 150 (1) ◽  
pp. 546-554 ◽  
Author(s):  
Norma A. S. Almeida ◽  
Aline Cordeiro ◽  
Danielle S. Machado ◽  
Luana L. Souza ◽  
Tânia M. Ortiga-Carvalho ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Dominant Negative ◽  
P Wave ◽  
Dominant Negative Mutant ◽  
Mrna Levels ◽  
Messenger Ribonucleic Acid ◽  
Wave Duration ◽  
P Wave Duration

Thyroid hormone (TH) regulates many cardiac genes via nuclear thyroid receptors, and hyperthyroidism is frequently associated with atrial fibrillation. Electrical activity propagation in myocardium depends on the transfer of current at gap junctions, and connexins (Cxs) 40 and 43 are the predominant junction proteins. In mice, Cx40, the main Cx involved in atrial conduction, is restricted to the atria and fibers of the conduction system, which also express Cx43. We studied cardiac expression of Cx40 and Cx43 in conjunction with electrocardiogram studies in mice overexpressing the dominant negative mutant thyroid hormone receptor-β Δ337T exclusively in cardiomyocytes [myosin heavy chain (MHC-mutant)]. These mice develop the cardiac hypothyroid phenotype in the presence of normal serum TH. Expression was also examined in wild-type mice rendered hypothyroid or hyperthyroid by pharmacological treatment. Atrial Cx40 mRNA and protein levels were decreased (85 and 55%, respectively; P < 0.001) in MHC-mt mice. Atrial and ventricular Cx43 mRNA levels were not significantly changed. Hypothyroid and hyperthyroid animals showed a 25% decrease and 40% increase, respectively, in Cx40 mRNA abundance. However, MHC-mt mice presented very low Cx40 mRNA expression regardless of whether they were made hypothyroid or hyperthyroid. Atrial depolarization velocity, as represented by P wave duration in electrocardiograms of unanesthetized mice, was extremely reduced in MHC-mt mice, and to a lesser extent also in hypothyroid mice (90 and 30% increase in P wave duration). In contrast, this measure was increased in hyperthyroid mice (19% decrease in P wave duration). Therefore, this study reveals for the first time that Cx40 mRNA is up-regulated by TH acting in cardiac atria via the TH receptor and that this may be one of the mechanisms contributing to atrial conduction alterations in thyroid dysfunctions. Cardiac-specific expression of a mutant thyroid hormone receptor unable to bind thyroid hormone profoundly reduces atrial connexin 40 expression in association with prolonged atrial conduction.

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