Expression of thyrotropin receptor and thyroid hormone receptor messenger ribonucleic acid in normal, hyperplastic, and neoplastic human thyroid tissue

1994 ◽  
Vol 79 (2) ◽  
pp. 384-389 ◽  
Author(s):  
M. Bronnegard
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Thyroid Tissue ◽  
Human Thyroid ◽  
Thyrotropin Receptor ◽  
Messenger Ribonucleic Acid ◽  
Human Thyroid Tissue

Expression of the Thyroid Hormone Receptor, the Oncogenes c-myc and H-ras, and the 90 kD Heat Shock Protein in Normal. Hyperplastic, and Neoplastic Human Thyroid Tissue

Thyroid ◽  
1992 ◽  
Vol 2 (4) ◽  
pp. 307-313 ◽  
Author(s):  
GÖRAN WALLIN ◽  
MIKAEL BRÖNNEGÅRD ◽  
LARS GRIMELIUS ◽  
JACQUELINE McGUIRE ◽  
OVE TØRRING
Keyword(s):  
Thyroid Hormone ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Thyroid Tissue ◽  
Human Thyroid ◽  
Human Thyroid Tissue

scholarly journals Multiple Messenger Ribonucleic Acid Variants Regulate Cell-Specific Expression of Human Thyroid Hormone Receptor β1

2004 ◽  
Vol 18 (7) ◽  
pp. 1631-1642 ◽  
Author(s):  
Sarah Frankton ◽  
Clare B. Harvey ◽  
Lisa M. Gleason ◽  
Abdessamad Fadel ◽  
Graham R. Williams
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Human Thyroid ◽  
Specific Expression ◽  
Messenger Ribonucleic Acid

Thyroid hormone receptor messenger ribonucleic acid in human granulosa and ovarian stromal cells

1994 ◽  
Vol 62 (3) ◽  
pp. 531-534 ◽  
Author(s):  
Anthony N. Wakim ◽  
William R. Paljug ◽  
Katherine M. Jasnosz ◽  
Nawar Alhakim ◽  
Anne B. Brown ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Stromal Cells ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Messenger Ribonucleic Acid

scholarly journals Overexpression of thyroid hormone receptor beta1 is associated with thyrotropin receptor gene expression and proliferation in a human thyroid carcinoma cell line

2000 ◽  
Vol 165 (2) ◽  
pp. 379-389 ◽  
Author(s):  
ST Chen ◽  
HY Shieh ◽  
JD Lin ◽  
KS Chang ◽  
KH Lin
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Thyroid Hormone ◽  
Cell Line ◽  
Cell Lines ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Human Thyroid ◽  
Thyrotropin Receptor ◽  
Tshr Gene

To correlate the differentiation phenotype of two human thyroid cancer cell lines with their expression of various molecular markers, we analyzed the mRNA levels of four thyroid-specific genes, including thyrotropin receptor (TSHR), thyroglobulin (Tg), thyroid transcription factor-1 (TTF-1), and paired-box containing transcription factor-8 (PAX-8) genes. The results showed a differentiation-status-related pattern in which a well-differentiated cell line (WRO) expressed all the four genes, in contrast to an anaplastic cell line (ARO) that expressed TTF-1 and reduced levels of TSHR, but no Tg or PAX-8 genes. Furthermore, to verify the finding of concomitant loss of beta subtype thyroid hormone receptor (TRbeta) and TSHR gene expression in neoplastic thyroid tumors (Bronnegard et al. 1994), we examined the expression levels of TRbeta1 gene in these cell lines. Whereas the WRO cells produced an abundant amount of TRbeta1 protein detectable by immunoprecipitation, the ARO cells produced none. This new observation prompted us to investigate whether overexpression of TRbeta1 protein in ARO cells might produce changes in the differentiation phenotypes. We found that the level of expression of the TSHR gene and the proliferative index of ARO cells were significantly upregulated in the cells stably transfected with wild-type TRbeta1. These findings suggest that TRbeta1 protein overexpression can affect the differentiation phenotypes and induce more efficient cell proliferation of the anaplastic ARO cells.

Prolonged Fasting Reduces Rat Hepaticβ1 Thyroid Hormone Receptor Protein without Changing the Level of Its Messenger Ribonucleic Acid*

Endocrinology ◽  
1991 ◽  
Vol 129 (6) ◽  
pp. 2881-2885 ◽  
Author(s):  
JAMES T. LANE ◽  
MADAN GODBOLE ◽  
KEVIN A. STRAIT ◽  
HAROLD L. SCHWARTZ ◽  
JACK H. OPPENHEIMER
Keyword(s):  
Thyroid Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Receptor Protein ◽  
Prolonged Fasting ◽  
Messenger Ribonucleic Acid

scholarly journals Transient Expression of c-erbAβ1 Messenger Ribonucleic Acid andβ 1 Thyroid Hormone Receptor Early in Adipogenesis of Ob 17 Cells*

Endocrinology ◽  
1999 ◽  
Vol 140 (7) ◽  
pp. 2983-2990 ◽  
Author(s):  
Alexandra Dace ◽  
Gaiane Sarkissian ◽  
Laetitia Schneider ◽  
Claire Martin-El Yazidi ◽  
Jeannine Bonne ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Transient Expression ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Thyroid Hormone Receptor ◽  
Messenger Ribonucleic Acid
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