scholarly journals Lack of an Association between Peroxisome Proliferator-Activated Receptor-γ Gene Pro12Ala Polymorphism and Adiponectin Levels in the Polycystic Ovary Syndrome

2004 ◽  
Vol 89 (10) ◽  
pp. 5110-5115 ◽  
Author(s):  
Francesco Orio ◽  
Stefano Palomba ◽  
Teresa Cascella ◽  
Sebastiano Di Biase ◽  
Donato Labella ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals Association of the Pro12Ala Polymorphism with the Metabolic Parameters in Women with Polycystic Ovary Syndrome

2017 ◽  
Vol 5 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Moushira Zaki ◽  
Naglaa Hassan ◽  
Hala T. El-Bassyouni ◽  
Sanaa Kamal ◽  
Walaa Basha ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Fasting Blood Glucose ◽  
Metabolic Parameters ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Ovary Syndrome ◽  
Metabolic Complications ◽  
Peroxisome Proliferator Activated Receptor ◽  
Significant Difference

AIM: To investigate the association of peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala polymorphism with polycystic ovary syndrome (PCOS) and its effect on the metabolic parameters in PCOS women.METHODS: The study used PCR to identify the presence of the PPARG Pro12Ala polymorphism in 100 PCOS women and 120 age-matched healthy women. All participants were subjected to anthropometry, biochemical and metabolic evaluation.RESULTS: Significant difference in the genotypes distributions of PPARG Pro12Ala polymorphism was observed among PCOS women and controls (p = 0.03). The frequency of the polymorphic allele Ala was significantly higher in PCOS cases than that in the controls (OR = 2.01, p = 0.01). The carries of the variant allele Ala in PCOS women showed significant higher values in body mass index (BMI), systolic and diastolic blood pressure, waist circumference, waist to hip ratio, sum of skin folds, fasting blood glucose, fasting blood insulin, HOMA-IR, fasting triglycerides, total cholesterol and low-density lipoprotein than non-carriers.CONCLUSION: The PPARG Pro12Ala polymorphism might contribute to the risk of PCOS and abnormal metabolic parameters and could be considered as a biomarker for early diagnosis and clinic prediction of metabolic complications.

Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in women with polycystic ovary syndrome

2006 ◽  
Vol 22 (6) ◽  
pp. 336-342 ◽  
Author(s):  
Murat Yilmaz ◽  
Mehmet Ali Ergün ◽  
Ayhan Karakoç ◽  
Erkan Yurtçu ◽  
Nuri Çakir ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals Association of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 with decreased basic metabolic rate in women with polycystic ovary syndrome

2009 ◽  
Vol 161 (2) ◽  
pp. 317-322 ◽  
Author(s):  
Vasiliki Koika ◽  
Dimitra J Marioli ◽  
Alexandros D Saltamavros ◽  
Vasiliki Vervita ◽  
Kleanthis D Koufogiannis ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Metabolic Rate ◽  
Polycystic Ovary ◽  
Total Testosterone ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ppar Γ ◽  
Genotype Frequencies

ObjectiveThe peroxisome proliferator-activated receptor (PPAR)γ is a transcription factor involved in glucose homeostasis and energy metabolism. A missense mutation at codon 12 in the PPARγ2 has been associated with increased body mass index (BMI) and attenuated insulin resistance (IR) in polycystic ovary syndrome (PCOS). We have recently shown a decreased basic metabolic rate (BMR) in PCOS. The aim of the present study is to determine the prevalence of the Pro12Ala polymorphism of the PPARγ2 gene and its associations with indices of IR and BMR in lean and slightly overweight PCOS women.DesignCase–control association study involving 156 PCOS women with biochemical hyperandrogenism, chronic anovulation and polycystic ovarian morphology in ultrasound and 56 unrelated healthy controls.MethodsHormonal determinations were performed by electrochemiluminescence quantitation or RIA. BMR was measured by indirect calorimetry. All subjects were genotyped by a PCR–restriction fragment length polymorphism assay.ResultsGenotype frequencies of the Pro12Ala polymorphism in PPARγ2 did not differ among PCOS women and control subjects.The presence of Pro12Ala polymorphism of PPARγ2 was associated with lower BMR (P=0.04). This finding was valid in our subgroup of lean PCOS (BMI<25 kg/m2), in which the Ala variant was also associated with higher total testosterone values.ConclusionThe Pro12Ala polymorphism in the PPARγ2 gene is associated with decreased BMR in women with PCOS and biochemical hyperandrogenemia. These young women are therefore at risk to increase their body weight and should restrict their energy intake by diet and enhance their energy expenditure by exercise.

scholarly journals Exon 6 and 2 Peroxisome Proliferator-Activated Receptor-γ Polymorphisms in Polycystic Ovary Syndrome

2003 ◽  
Vol 88 (12) ◽  
pp. 5887-5892 ◽  
Author(s):  
Francesco Orio ◽  
Giuseppe Matarese ◽  
Sebastiano Di Biase ◽  
Stefano Palomba ◽  
Donato Labella ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Peroxisome Proliferator ◽  
Pro12ala Polymorphism ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor ◽  
Exon 2 ◽  
Ppar Γ ◽  
Significant Difference ◽  
Shed Light

Abstract Obesity affects about 44% of women with polycystic ovary syndrome (PCOS). Peroxisome proliferator-activated receptor-γ (PPAR-γ) is one of the genes involved in the differentiation of adipose tissue. In an attempt to shed light on the high percentage of obesity in PCOS, we examined polymorphisms at exons 6 and 2 of the PPAR-γ gene in 100 PCOS patients and in 100 healthy controls matched for age and body mass index (BMI). The T allele frequency of exon 6 was significantly higher (P &lt; 0.05) in PCOS patients compared with control women. In addition, the BMI and leptin levels were significantly higher (P &lt; 0.05) in PCOS patients carrying the C→T substitution than in controls. There was no significant difference in leptin levels after normalization for BMI. The Pro12Ala polymorphism at exon 2 was unrelated to BMI and/or leptin levels in PCOS women. In conclusion, the higher frequency of the C→T substitution in exon 6 of the PPAR-γ gene in PCOS women suggests that it plays a role in the complex pathogenetic mechanism of obesity in PCOS, whereas the Pro12Ala polymorphism does not seem to affect BMI in PCOS women.

Associations of Leptin Receptor and Peroxisome Proliferator-Activated Receptor Gamma Polymorphisms with Polycystic Ovary Syndrome: A Meta-Analysis

2019 ◽  
Vol 75 (1) ◽  
pp. 1-8
Author(s):  
Jialang Liang ◽  
Jiarong Lan ◽  
Min Li ◽  
Fang Wang
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Leptin Receptor ◽  
Genetic Model ◽  
Polycystic Ovary ◽  
Meta Analysis ◽  
Peroxisome Proliferator ◽  
Ovary Syndrome ◽  
Peroxisome Proliferator Activated Receptor ◽  
Subgroup Analyses ◽  
The Relationship

Background: Previous studies on associations of leptin receptor (LEPR) and peroxisome proliferator-activated receptor gamma (PPARG) polymorphisms with polycystic ovary syndrome (PCOS) yielded conflicting results. Objectives: In this meta-analysis, we aimed to better analyze the relationship between LEPR/PPARG polymorphisms and PCOS in a larger pooled population. Methods: We performed a systematic search of PubMed, Web of Science, Embase and CNKI. We calculated pooled ORs and 95% CIs to estimate associations between LEPR/PPARG polymorphisms and PCOS. Results: Totally, 33 eligible studies were included. A significant association with susceptibility to PCOS was observed for LEPR rs1137101 polymorphism under recessive genetic model (p = 0.002, OR 1.88, 95% CI 1.26–2.78, I2 = 42%) and for PPARG rs1801282 polymorphism under dominant (p = 0.007, OR 1.20, 95% CI 1.05–1.36, I2 = 49%), overdominant (p = 0.02, OR 0.85, 95% CI 0.74–0.97, I2 = 48%), and allele (p = 0.006, OR 1.18, 95% CI 1.05–1.33, I2 = 47%) genetic models in overall population. Further subgroup analyses by ethnicity revealed that LEPR rs1137101 and PPARG rs3856806 polymorphisms were both significantly associated with susceptibility to PCOS in Asians. No any positive results were detected in overall and subgroup analyses. Conclusions: Our meta-analysis suggested that LEPR rs1137101, PPARG rs1801282, and rs3856806 polymorphisms were all significantly associated with individual susceptibility to PCOS in certain populations.

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