scholarly journals Epitope-Restricted 65-Kilodalton Glutamic Acid Decarboxylase Autoantibodies among New-Onset Sardinian Type 2 Diabetes Patients Define Phenotypes of Autoimmune Diabetes

2004 ◽  
Vol 89 (11) ◽  
pp. 5675-5682 ◽  
Author(s):  
Mario Maioli ◽  
Emilyn Alejandro ◽  
Giancarlo Tonolo ◽  
Lisa K. Gilliam ◽  
Lynn Bekris ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Autoimmune Diabetes ◽  
Acid Decarboxylase ◽  
Glutamic Acid Decarboxylase Autoantibodies ◽  
New Onset ◽  
Diabetes Patients

scholarly journals Combined treatment with sitagliptin and vitamin D in a patient with latent autoimmune diabetes in adults

2016 ◽  
Vol 2016 ◽  
Author(s):  
E Rapti ◽  
S Karras ◽  
M Grammatiki ◽  
A Mousiolis ◽  
X Tsekmekidou ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Autoimmune Diabetes ◽  
Combined Treatment ◽  
Acid Decarboxylase ◽  
Latent Autoimmune Diabetes ◽  
Glutamic Acid Decarboxylase Antibodies

Summary Latent autoimmune diabetes in adults (LADA) is a relatively new type of diabetes with a clinical phenotype of type 2 diabetes (T2D) and an immunological milieu characterized by high titers of islet autoantibodies, resembling the immunological profile of type 1 diabetes (T1D). Herein, we report a case of a young male, diagnosed with LADA based on both clinical presentation and positive anti-glutamic acid decarboxylase antibodies (GAD-abs), which were normalized after combined treatment with a dipeptidyl peptidase-4 inhibitor (DPP-4) (sitagliptin) and cholecalciferol. Learning points Anti-glutamic acid decarboxylase antibodies (GAD-abs) titers in young patients being previously diagnosed as type 2 diabetes (T2D) may help establish the diagnosis of latent autoimmune diabetes in adults (LADA). Sitagliptin administration in patients with LADA might prolong the insulin-free period. Vitamin D administration in patients with LADA might have a protective effect on the progression of the disease.

Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes

Autoimmunity ◽  
2009 ◽  
Vol 42 (6) ◽  
pp. 507-514 ◽  
Author(s):  
Bledar Daka ◽  
Maria K. Svensson ◽  
Åke Lernmark ◽  
Lucia Mincheva-Nilsson ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Binding Assays
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