scholarly journals Age- and Gender-Specific TSH Reference Intervals in People With No Obvious Thyroid Disease in Tayside, Scotland: The Thyroid Epidemiology, Audit, and Research Study (TEARS)

2013 ◽  
Vol 98 (3) ◽  
pp. 1147-1153 ◽  
Author(s):  
Thenmalar Vadiveloo ◽  
Peter T. Donnan ◽  
Michael J. Murphy ◽  
Graham P. Leese
2018 ◽  
Vol 14 (2) ◽  
pp. 151-159 ◽  
Author(s):  
Xin Li ◽  
Di Wang ◽  
Chun Yang ◽  
Qi Zhou ◽  
Suo-Lang Zhuoga ◽  
...  

Author(s):  
Peter Ridefelt ◽  
Mattias Aldrimer ◽  
Per-Olof Rödöö ◽  
Frank Niklasson ◽  
Leif Jansson ◽  
...  

AbstractReference intervals are crucial decision-making tools aiding clinicians in differentiating between healthy and diseased populations. However, for children such values often are lacking or incomplete.Blood samples were obtained from 692 healthy children, aged 6 months to 18 years, recruited in daycare centers and schools. Twelve common general clinical chemistry analytes were measured on the Abbott Architect ci8200 platform; sodium, potassium, chloride, calcium, albumin-adjusted calcium, phosphate, magnesium, creatinine (Jaffe and enzymatic), cystatin C, urea and uric acid.Age- and gender specific pediatric reference intervals were defined by calculating the 2.5th and 97.5th percentiles.The data generated is primarily applicable to a Caucasian population when using the Abbott Architect platform, but could be used by any laboratory if validated for the local patient population.


2018 ◽  
Vol 64 (06/2018) ◽  
Author(s):  
Yanhui Zhu ◽  
Yulin Yuan ◽  
Xiafang Yang ◽  
Qiuwei Lu ◽  
Xiaoxu Lu ◽  
...  

2018 ◽  
Vol 64 (04/2018) ◽  
Author(s):  
Shu-Fen Wang ◽  
Lan-Fu Li ◽  
Chun-Mei Ding ◽  
Zhi-De Hu

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Wolfgang Hermann ◽  
Lorenz Risch ◽  
Chris Grebhardt ◽  
Urs E. Nydegger ◽  
Benjamin Sakem ◽  
...  

AbstractObjectivesMean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) possess diagnostic and prognostic capabilities in a variety of diseases. We aimed to establish reference intervals (RI) for platelet indices (PI) in seniors.MethodsWe established direct and indirect RI for MPV, PDW, and PCT in selected reference individuals aged 60 years and older. Abnormal PI were assessed in a population-based setting in the Principality of Liechtenstein, where 37.7% of the whole nation’s population aged 60 years and older had PI determined by hematology analyzers from Sysmex (Horgen, Switzerland).ResultsAmong 689 female and 542 male participants, MPV and PDW did not exhibit age- and gender-specific differences, whereas PCT in females also displayed no age-specific differences. Age- and sex-independent RI were 9.3–12.5 fl for MPV and 10.1–16.7% for PDW, whereas the age-independent RI for PCT in women was 0.18–0.37. In males, age-specific RI for PCT were 0.16–0.30 (age 60–69), 0.15–0.33 (age 70–79), and 0.14–0.33 (age 80 and older). The population-based frequency of abnormal PI results was 0.8% (MPV), 1.1% (PDW), and 24.4% (PCT).ConclusionsApplying novel RI for PI reveals that only approximately 1% of patients exhibit abnormal MPV and PDW. Abnormal PCT is observed much more frequently.


1996 ◽  
Vol 42 (4) ◽  
pp. 630-636 ◽  
Author(s):  
K Rasmussen ◽  
J Møller ◽  
M Lyngbak ◽  
A M Pedersen ◽  
L Dybkjaer

Abstract We present reference intervals for total homocysteine and methylmalonic acid in plasma based on samples from 126 women (ages 20-85 years, median 49 years) and 109 men (ages 20-84 years, median 50 years). The central 0.95 interval for methylmalonic acid was 0.08-0.28 micromol/L. Supplementation with cyanocobalamin caused a nonsignificant decrease in methylmalonic acid. Supplementation with folic acid caused a decrease in homocysteine concentrations, with data analysis identifying two significantly different clusters: 182 subjects with the lowest initial concentrations (7.76 +/- 1.54 micromol/L, mean +/- SD) and the smallest decrease (1.26 +/- 0.96 micromol/L), and 53 subjects with the highest initial concentrations (12.33 +/- 2.04 micromol/L) and greatest decrease (4.14 +/- 1.32 micromol/L). We argue in favor of the age- and gender-specific central 0.95 intervals obtained for the 182 subjects before being supplemented with folic acid: 4.6-8.1 micromol/L for subjects at <30 years; 4.5-7.9 micromol/L for women, ages 30-59 years; 6.3-11.2 micromol/L for men, ages 30-59 years; and 5.8-11.9 micromol/L for subjects at >60 years.


2011 ◽  
Vol 53 (6) ◽  
pp. 814-819 ◽  
Author(s):  
Waleed Tamimi ◽  
Hani Tamim ◽  
Naila Felimban ◽  
Angham AlMutair ◽  
Yasmin Altwaijri ◽  
...  

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