scholarly journals Serum Sclerostin Levels Vary With Season

2014 ◽  
Vol 99 (1) ◽  
pp. E149-E152 ◽  
Author(s):  
Bess Dawson-Hughes ◽  
Susan S. Harris ◽  
Lisa Ceglia ◽  
Nancy J. Palermo
Keyword(s):  
Physical Activity ◽  
Seasonal Variation ◽  
Clinical Utility ◽  
Older Men ◽  
Serum Osteocalcin ◽  
Biological Variability ◽  
Men And Women ◽  
Potential Clinical Utility ◽  
Serum Pth ◽  
Older Men And Women

Context: To establish the clinical utility of serum sclerostin levels, it is important to know whether there is seasonal variation in the measurements. Objective: This study was done to determine whether serum sclerostin levels vary by season in healthy older men and women. Methods: Serum sclerostin levels were measured in archived serum of 314 healthy men and women aged 65 years and older and examined for seasonal variation. Several factors known to vary by season and previously reported to be associated with serum sclerostin levels, including serum osteocalcin, physical activity, and serum PTH levels, were also measured in these subjects. Sex did not modify the association of season with sclerostin, so the men and women were analyzed together. Results: Serum sclerostin levels varied significantly by season (P < .001, after adjustment for sex). Sclerostin levels in the wintertime were 20% higher than the all-year mean, the levels gradually declined through the spring and summer, and by the fall, they were 20% below the all-year mean. Adjustment for serum osteocalcin, physical activity, and serum PTH did not alter the seasonal means. Seasonal differences in serum osteocalcin, physical activity, and serum PTH were not statistically significant. Conclusions: This study documents marked seasonal variation in serum sclerostin levels. It is important to recognize this source of biological variability when considering the potential clinical utility of sclerostin measurements.

Abstract P036: Parathyroid Hormone is Associated with All-Cause and Cardiovascular Mortality: The Hoorn Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Adriana J van Ballegooijen ◽  
Ilse Reinders ◽  
Marjolein Visser ◽  
Jacqueline M Dekker ◽  
Giel Nijpels ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Cox Regression ◽  
Threshold Model ◽  
Older Men ◽  
Population Based ◽  
Survival Curves ◽  
Men And Women ◽  
Serum Pth ◽  
Older Men And Women ◽  
Cvd Mortality

Introduction Higher parathyroid hormone (PTH) concentrations have been associated with increased cardiovascular disease (CVD) mortality, although data in the general population are scarce. Hypothesis We hypothesize that higher serum PTH concentrations are associated with all-cause and CVD mortality in a prospective, population-based cohort of older men and women. Methods We included 633 participants of the Hoorn Study, a population-based cohort with oversampling of subjects with impaired glucose regulation; mean age 70.1±6.6 years, 50.7% female. Serum intact PTH concentrations were measured using a 2-site immunoassay. Outcomes were all-cause and CVD mortality based on clinical files and coded according to the ICD-9. We used Cox-regression to estimate survival curves and hazard ratios (HR 95% CI) for all-cause and CVD mortality adjusted for potential confounders using season-specific PTH quartiles. Results During a median follow-up of 7.8 years, 112 participants died, of which 26 deaths (23%) were due to CVD. Survival curves showed an impaired survival for all-cause (Log-rank p=0.054) and CVD mortality (Log-rank p=0.022) for people in the highest PTH quartile (Figure 1). In a multivariate model adjusted for age, sex, smoking, education level, BMI, glucose status, systolic blood pressure, anti-hypertensive drug use, the highest PTH quartile was associated with higher all-cause mortality; HR 1.98 (1.08, 3.64). Kidney function (estimated glomerular filtration rate and micro-albuminuria) attenuated the PTH risk association, but risk persisted; HR 1.93 (95% CI 1.04, 3.58). The results for CVD mortality showed a similar pattern, although the association was only significant in a threshold model (Quartile 4 vs. Quartile 1-3) HR 2.56 (1.11, 5.94). Conclusion In conclusion, among older men and women, higher PTH concentrations are associated with higher mortality risk. We suggest to evaluate whether individuals with high PTH concentrations benefit from therapeutic approaches targeted to decrease PTH concentrations.

scholarly journals Motives for physical activity in older men and women: A twin study using accelerometer‐measured physical activity

2020 ◽  
Vol 30 (8) ◽  
pp. 1409-1422 ◽  
Author(s):  
Sari Aaltonen ◽  
Katja Waller ◽  
Henri Vähä‐Ypyä ◽  
Juha Rinne ◽  
Harri Sievänen ◽  
...  
Keyword(s):  
Physical Activity ◽  
Twin Study ◽  
Older Men ◽  
Men And Women ◽  
Older Men And Women

scholarly journals Longitudinal changes in body composition in older men and women: role of body weight change and physical activity

2002 ◽  
Vol 76 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Virginia A Hughes ◽  
Walter R Frontera ◽  
Ronenn Roubenoff ◽  
William J Evans ◽  
Maria A Fiatarone Singh
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Body Weight ◽  
Weight Change ◽  
Older Men ◽  
Body Weight Change ◽  
Men And Women ◽  
Longitudinal Changes ◽  
Older Men And Women

scholarly journals Habitual physical activity and the risk for depressive and anxiety disorders among older men and women

2010 ◽  
Vol 23 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Julie A. Pasco ◽  
Lana J. Williams ◽  
Felice N. Jacka ◽  
Margaret J. Henry ◽  
Carolyn E. Coulson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Anxiety Disorders ◽  
De Novo ◽  
Older Men ◽  
Habitual Physical Activity ◽  
Activity Score ◽  
Standard Deviation Increase ◽  
Men And Women ◽  
Physical Activity Score ◽  
Older Men And Women

ABSTRACTBackground: Regular physical activity is generally associated with psychological well-being, although there are relatively few prospective studies in older adults. We investigated habitual physical activity as a risk factor for de novo depressive and anxiety disorders in older men and women from the general population.Methods: In this nested case-control study, subjects aged 60 years or more were identified from randomly selected cohorts being followed prospectively in the Geelong Osteoporosis Study. Cases were individuals with incident depressive or anxiety disorders, diagnosed using the Structured Clinical Interview for DSM-IV-TR (SCID-I/NP); controls had no history of these disorders. Habitual physical activity, measured using a validated questionnaire, and other exposures were documented at baseline, approximately four years prior to psychiatric interviews. Those with depressive or anxiety disorders that pre-dated baseline were excluded.Results: Of 547 eligible subjects, 14 developed de novo depressive or anxiety disorders and were classified as cases; 533 controls remained free of disease. Physical activity was protective against the likelihood of depressive and anxiety disorders; OR = 0.55 (95% CI 0.32–0.94), p = 0.03; each standard deviation increase in the transformed physical activity score was associated with an approximate halving in the likelihood of developing depressive or anxiety disorders. Leisure-time physical activity contributed substantially to the overall physical activity score. Age, gender, smoking, alcohol consumption, weight and socioeconomic status did not substantially confound the association.Conclusion: This study provides evidence consistent with the notion that higher levels of habitual physical activity are protective against the subsequent risk of development of de novo depressive and anxiety disorders.

scholarly journals Associations of dietary intake and physical activity with intramyocellular lipid content in older men and women

2007 ◽  
Vol 21 (6) ◽  
Author(s):  
Gracen Hauk ◽  
Dennis H Sullivan ◽  
William J Evans ◽  
Reza Hakkak ◽  
Margaret M Harris ◽  
...  
Keyword(s):  
Physical Activity ◽  
Dietary Intake ◽  
Lipid Content ◽  
Older Men ◽  
Intramyocellular Lipid ◽  
Men And Women ◽  
Intramyocellular Lipid Content ◽  
Older Men And Women
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