scholarly journals Physical activity and long-term survival in older men and women: A 21 year longitudinal study

2018 ◽  
Vol 43 (4) ◽  
pp. 294-314
Author(s):  
Wasim Ahmed ◽  
Oluwafemi Fayoyin ◽  
Peter A. Bath
2008 ◽  
Vol 97 (7) ◽  
pp. 583-591 ◽  
Author(s):  
Liqian Liu ◽  
Ann L. Coker ◽  
Xianglin L. Du ◽  
Janice N. Cormier ◽  
Charles E. Ford ◽  
...  

2019 ◽  
Vol 54 (1) ◽  
pp. 1802175 ◽  
Author(s):  
Mathias Baumert ◽  
Dominik Linz ◽  
Katie Stone ◽  
R. Doug McEvoy ◽  
Steve Cummings ◽  
...  

Respiratory frequency (fR) predicts in-hospital and short-term mortality in patients with a variety of pathophysiological conditions, but its predictive value for long-term cardiovascular and all-cause mortality in the general population is unknown. Here, we investigated the relationship between mean nocturnal fR and mortality in community-dwelling older men and women.We measured mean nocturnal fR during sleep from overnight polysomnography in 2686 men participating in the Osteoporotic Fractures in Men Study (MrOS) Sleep study and 406 women participating in the Study of Osteoporotic Fractures (SOF) to investigate the relationship between mean nocturnal fR and long-term cardiovascular and all-cause mortality.166 (6.1%) men in the MrOS cohort (8.9±2.6 years’ follow-up) and 46 (11.2%) women in the SOF cohort (6.4±1.6 years’ follow-up) died from cardiovascular disease. All-cause mortality was 51.2% and 26.1% during 13.7±3.7 and 6.4±1.6 years’ follow-up in the MrOS Sleep study and the SOF cohorts, respectively. Multivariable Cox regression analysis adjusted for significant covariates demonstrated that fR dichotomised at 16 breaths·min−1 was independently associated with cardiovascular mortality (MrOS: hazard ratio (HR) 1.57, 95% CI 1.14–2.15; p=0.005; SOF: HR 2.58, 95% CI 1.41–4.76; p=0.002) and all-cause mortality (MrOS: HR 1.18, 95% CI 1.04–1.32; p=0.007; SOF: HR 1.50, 95% CI 1.02–2.20; p=0.04).In community-dwelling older men and women, polysomnography-derived mean nocturnal fR ≥16 breaths·min−1 is an independent predictor of long-term cardiovascular and all-cause mortality. Whether nocturnal mean fR can be used as a risk marker warrants further prospective studies.


2020 ◽  
Vol 30 (8) ◽  
pp. 1409-1422 ◽  
Author(s):  
Sari Aaltonen ◽  
Katja Waller ◽  
Henri Vähä‐Ypyä ◽  
Juha Rinne ◽  
Harri Sievänen ◽  
...  

2002 ◽  
Vol 76 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Virginia A Hughes ◽  
Walter R Frontera ◽  
Ronenn Roubenoff ◽  
William J Evans ◽  
Maria A Fiatarone Singh

2014 ◽  
Vol 99 (1) ◽  
pp. E149-E152 ◽  
Author(s):  
Bess Dawson-Hughes ◽  
Susan S. Harris ◽  
Lisa Ceglia ◽  
Nancy J. Palermo

Context: To establish the clinical utility of serum sclerostin levels, it is important to know whether there is seasonal variation in the measurements. Objective: This study was done to determine whether serum sclerostin levels vary by season in healthy older men and women. Methods: Serum sclerostin levels were measured in archived serum of 314 healthy men and women aged 65 years and older and examined for seasonal variation. Several factors known to vary by season and previously reported to be associated with serum sclerostin levels, including serum osteocalcin, physical activity, and serum PTH levels, were also measured in these subjects. Sex did not modify the association of season with sclerostin, so the men and women were analyzed together. Results: Serum sclerostin levels varied significantly by season (P < .001, after adjustment for sex). Sclerostin levels in the wintertime were 20% higher than the all-year mean, the levels gradually declined through the spring and summer, and by the fall, they were 20% below the all-year mean. Adjustment for serum osteocalcin, physical activity, and serum PTH did not alter the seasonal means. Seasonal differences in serum osteocalcin, physical activity, and serum PTH were not statistically significant. Conclusions: This study documents marked seasonal variation in serum sclerostin levels. It is important to recognize this source of biological variability when considering the potential clinical utility of sclerostin measurements.


2010 ◽  
Vol 23 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Julie A. Pasco ◽  
Lana J. Williams ◽  
Felice N. Jacka ◽  
Margaret J. Henry ◽  
Carolyn E. Coulson ◽  
...  

ABSTRACTBackground: Regular physical activity is generally associated with psychological well-being, although there are relatively few prospective studies in older adults. We investigated habitual physical activity as a risk factor for de novo depressive and anxiety disorders in older men and women from the general population.Methods: In this nested case-control study, subjects aged 60 years or more were identified from randomly selected cohorts being followed prospectively in the Geelong Osteoporosis Study. Cases were individuals with incident depressive or anxiety disorders, diagnosed using the Structured Clinical Interview for DSM-IV-TR (SCID-I/NP); controls had no history of these disorders. Habitual physical activity, measured using a validated questionnaire, and other exposures were documented at baseline, approximately four years prior to psychiatric interviews. Those with depressive or anxiety disorders that pre-dated baseline were excluded.Results: Of 547 eligible subjects, 14 developed de novo depressive or anxiety disorders and were classified as cases; 533 controls remained free of disease. Physical activity was protective against the likelihood of depressive and anxiety disorders; OR = 0.55 (95% CI 0.32–0.94), p = 0.03; each standard deviation increase in the transformed physical activity score was associated with an approximate halving in the likelihood of developing depressive or anxiety disorders. Leisure-time physical activity contributed substantially to the overall physical activity score. Age, gender, smoking, alcohol consumption, weight and socioeconomic status did not substantially confound the association.Conclusion: This study provides evidence consistent with the notion that higher levels of habitual physical activity are protective against the subsequent risk of development of de novo depressive and anxiety disorders.


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