Thyroid Function in Adults with Down's Syndrome

1977 ◽  
Vol 44 (3) ◽  
pp. 453-458 ◽  
Author(s):  
J. C. MURDOCH ◽  
W. A. RATCLIFFE ◽  
D. G. McLARTY ◽  
J. C. RODGER ◽  
J. G. RATCLIFFE
Keyword(s):  
Thyroid Function ◽  
Down's Syndrome ◽  
Down’S Syndrome

THYROID FUNCTION TESTS IN ADULTS WITH DOWN'S SYNDROME

1978 ◽  
Vol 88 (1) ◽  
pp. 48-54 ◽  
Author(s):  
S. Korsager ◽  
E. M. Chatham ◽  
H. P. Østergaard Kristensen
Keyword(s):  
Thyroid Function ◽  
Down's Syndrome ◽  
Clinical Signs ◽  
Down’S Syndrome ◽  
Thyroid Stimulating Hormone ◽  
Thyroid Function Tests ◽  
Thyroid Status ◽  
Biochemical Tests ◽  
Old Patients ◽  
Function Tests

ABSTRACT Thyroid status was studied in 24 patients above the age of 40 years with Down's syndrome. Three patients had thyroid function tests indicating hypothyroidism. Eight patients had thyroid autoantibodies in serum and 8 patients had a higher than normal level of thyroid stimulating hormone in serum. None of the patients had figures indicating thyrotoxicosis. None of the patients showed any of the clinical signs usually seen in patients with hypothyroidism. It is concluded that biochemical tests indicating hypothyroidism are much more often seen in patients with Down's syndrome than in normal subjects and that thyroid status should be assessed in old patients with this disease.

THYROID DISEASE AMONG CHILDREN WITH DOWN'S SYNDROME (MONGOLISM)

PEDIATRICS ◽  
1965 ◽  
Vol 36 (4) ◽  
pp. 608-614
Author(s):  
Alvin B. Hayles ◽  
Ward L. Hinrichs ◽  
W. Newlon Tauxe
Keyword(s):  
Iron Deficiency ◽  
Thyroid Function ◽  
Binding Capacity ◽  
Down's Syndrome ◽  
Clinical Manifestations ◽  
Down’S Syndrome ◽  
Primary Hypothyroidism ◽  
Deficiency Anemia ◽  
Carrier Protein ◽  
Normal Children

Observations on two mongoloid children, one having primary hypothyroidism and the other having primary hyperthyroidism, have been reported. Primary hypothyroidism in the mongoloid child, in each of the three cases reported to date, has been associated with uterine bleeding attributed to hormonal overlap in the pituitary feedback mechanism. The significance of this phenomenon is not clean. A total of sixteen cases of mongolism with hyperthyroidism have been described. There is no evidence that altered thyroid function plays a role in the clinical manifestations of mongolism, and significant alteration in thyroid function is uncommon among such patients. Both of the carrier protein systems responded to the stresses of the superimposed disease processes in these mongoloid children as they do in normal children. Specifically, the values for the erythrocytic uptake of 1-I131-triiodothyronine and thyroxine and the triiodothynonine binding capacities (Case 2 only) were all in the expected ranges for both thyroid derangements involved. Similarly, in Case 2, where an iron-deficiency anemia was also present, the increase in the iron binding capacity and presumably in the level of transferrin was on the order of that to be expected for the degree of iron deficiency. The response to stress of both carrier protein systems in Down's Syndrome suggests that protein synthesis of transferrin and TBG is normal.

Hypothyroidism in Down's Syndrome

1988 ◽  
Vol 153 (1) ◽  
pp. 102-104 ◽  
Author(s):  
Chinta Mani
Keyword(s):  
Clinical Features ◽  
Thyroid Function ◽  
Thyroid Dysfunction ◽  
Down's Syndrome ◽  
Thyroid Tissue ◽  
Down’S Syndrome ◽  
Thyroid Function Tests ◽  
Function Tests

Fifty-five adult Down's syndrome subjects resident at Northgate Hospital were screened for the presence of thyroid dysfunction. Approximately 50% of the subjects had clinical features suggestive of hypothyroidism, sufficient to require thyroid-function tests. Twenty-two per cent of the total suffered from some degree of hypothyroidism, and 16% had positive antibodies to thyroid tissue.

scholarly journals Thyroid Function in Kuwaiti Subjects with Down’s Syndrome

2002 ◽  
Vol 11 (4) ◽  
pp. 206-209 ◽  
Author(s):  
Fawzi E. Ali ◽  
Hossam A. Bayoumy ◽  
Abdul Salam R. Mohammad ◽  
Waleed A. Al-Busairi ◽  
Abdul Naser A. Al-Othman
Keyword(s):  
Thyroid Function ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Subclinical Hypothyroidism as the Most Common Thyroid Dysfunction Status in Children With Down’s Syndrome

2022 ◽  
Vol 12 ◽  
Author(s):  
Kamila Szeliga ◽  
Aleksandra Antosz ◽  
Karolina Skrzynska ◽  
Barbara Kalina-Faska ◽  
Aleksandra Januszek-Trzciakowska ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Lymphoblastic Leukemia ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Overt Hypothyroidism ◽  
Z Score ◽  
The Mean ◽  
Thyroid Dysfunctions ◽  
Antithyroid Autoantibodies

IntroductionThyroid dysfunctions are one of the most common abnormalities coexisting in children with Down’s syndrome (DS) and have been reported in up to 54% of cases.Aim of the StudyThe purposes of this retrospective study were to investigate the course of subclinical hypothyroidism in children with DS, to evaluate the thyroid function of these subjects in relation to the risk of developing overt thyroid disease and autoimmunity, and to identify clinical and biochemical characteristics of patients prescribed L-T4 therapy in children and adolescents with DS and SH.Material and MethodsThe records of DS patients referred to the Endocrinology Outpatient Clinic between 2010 and 2015 for screening of thyroid function were observed till the end of 2019 June and analyzed retrospectively. The children diagnosed with congenital hypothyroidism, acute lymphoblastic leukemia, and seizures and treated with drugs that may have interfered with thyroid function like lithium, antiepileptic, or iodinated drugs and glucocorticoids were excluded from the study.ResultsThe data of 77 DS patients were collected, evaluated, and analyzed. The study group consisted of 73 patients (32 girls and 41 boys with the mean age at baseline of 3.0 ± 4.5 years). A total of 63/73 (87%) children were diagnosed with SH. The 16/63 (25.4%) patients were followed-up without the treatment (group SH-T0), and therapy with levothyroxine (L-T4) was introduced in 47/63 (74.6%) SH children with a mean dosage of 1.8 ± 1.0 μg/kg/day (group SH-T1). Thyroxine supplementation did not improve growth expressed as ΔhSDS (0.1 ± 1.3, ranged −2.1 to 3.8 in SH-T0 vs. 0.0 ± 0.7, ranged −1.7 to 1.4 in SH-T1, p = 0.96) and ΔBMI Z-score (0.3 ± 0.9, ranged −0.9 to 2.6 in SH-T0 vs. 0.3 ± 1.1, ranged −2.1 to 2.9 in SH-T1, p = 0.65). Positive anti-TPO and anti-TG antibodies were detected in 7/63 (11.1%) DS cases.ConclusionsSH is the most frequent presentation of thyroid gland dysfunction in DS children. A small percentage of patients develop an overt hypothyroidism, particularly in females with mostly positive titer of antithyroid autoantibodies.

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