Tumor-Induced Vitamin D-Resistant Hypophosphatemic Osteomalacia Associated with Proximal Renal Tubular Dysfunction and 1,25-Dihydroxyvitamin D Deficiency

1979 ◽  
Vol 49 (6) ◽  
pp. 873-878 ◽  
Author(s):  
YASUAKI FUKUMOTO ◽  
SEIICHIRO TARUI ◽  
KEIKO TSUKIYAMA ◽  
KIKUO ICHIHARA ◽  
KANAME MORIWAKI ◽  
...  
Keyword(s):  
Vitamin D ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Proximal Renal Tubular Dysfunction ◽  
Hypophosphatemic Osteomalacia ◽  
Renal Tubular

scholarly journals Chest Deformity and Disability due to Tenofovir-Induced Hypophosphatemic Osteomalacia: Case Report and Call for Improved Global Access to Laboratory Testing

2017 ◽  
Vol 16 (5) ◽  
pp. 430-432 ◽  
Author(s):  
Jan Hajek ◽  
Simple Ouma ◽  
Juliya Hemmett ◽  
Rob Starko ◽  
Paska Apiyo
Keyword(s):  
Risk Factors ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Mineral Density ◽  
Skeletal Deformity ◽  
Proximal Renal Tubular Dysfunction ◽  
Chest Deformity ◽  
Hypophosphatemic Osteomalacia ◽  
Tubular Toxicity ◽  
Renal Tubular

Millions of people worldwide take tenofovir disoproxil fumarate (TDF) for the treatment of human immunodeficiency virus (HIV) and/or hepatitis B infection. Although generally safe and well tolerated, clinicians need to be aware that TDF can cause proximal renal tubular dysfunction and loss of bone mineral density, especially in patients with concomitant renal disease or other risk factors. We present the case of a patient with chronic HIV infection and urethral stricture who developed TDF-related proximal renal tubular dysfunction with hypophosphatemia and osteomalacia, presenting with bone pains, skeletal deformity, and disability. We review risk factors for TDF-related renal tubular toxicity and recommendations for monitoring creatinine, phosphate, alkaline phosphatase, and urinalysis.

Proximal Renal Tubular Dysfunction Related to Antiretroviral Therapy Among HIV-Infected Patients in an HIV Clinic in Mexico

2015 ◽  
Vol 29 (4) ◽  
pp. 181-185 ◽  
Author(s):  
Karen Andrade-Fuentes ◽  
José A. Mata-Marín ◽  
José I. López-De León ◽  
Bulmaro Manjarrez-Téllez ◽  
Jorge L. Sandoval Ramírez ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Proximal Renal Tubular Dysfunction ◽  
Renal Tubular

scholarly journals The association between serum vitamin D levels and renal tubular dysfunction in a general population exposed to cadmium in China

PLoS ONE ◽  
2018 ◽  
Vol 13 (4) ◽  
pp. e0195682 ◽  
Author(s):  
Xiao Chen ◽  
Yan Dai ◽  
Zhongqiu Wang ◽  
Guoying Zhu ◽  
Xiaoqiang Ding ◽  
...  
Keyword(s):  
Vitamin D ◽  
General Population ◽  
Serum Vitamin ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Renal Tubular

VITAMIN D DEPENDENCY: AN INHERITED POSTNATAL SYNDROME WITH SECONDARY HYPERPARATHYROIDISM

PEDIATRICS ◽  
1970 ◽  
Vol 46 (6) ◽  
pp. 871-880
Author(s):  
C. Arnaud ◽  
R. Maijer ◽  
T. Reade ◽  
C. R. Scriver ◽  
D. T. Whelan
Keyword(s):  
Vitamin D ◽  
Autosomal Recessive ◽  
Hypophosphatemic Rickets ◽  
First Year ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Recessive Trait ◽  
Daily Allowance ◽  
Renal Tubular ◽  
First Year Of Life

Three French-Canadian children in a large inbred pedigree each developed hypocalcemic, hypophosphatemic rickets in the latter half of their first year of life; there were also manifestations of generalized renal tubular dysfunction. These abnormalities, which mimic advanced Vitamin D deficiency, disappeared only when Vitamin D2 or D3 was given at about 100 times the recommended daily allowance; this indicated the diagnosis of Vitamin D dependency. Enamel hypoplasia was a prominent clinical finding; only those teeth which calcify postnatally were affected, indicating that the condition found does not affect Vitamin D-dependent nutrition in utero. The level of parathyroid hormone was elevated in serum before treatment; it fell to normal either after treatment with Vitamin D, or during intravenous infusion with a calcium solution sufficient to produce hypercalcemia. Vitamin D dependency appeared to be inherited as an autosomal recessive trait in this pedigree, but we could observe no phenotypic signs in presumably obligate heterozygotes. One of the three cases in the pedigree arose from outbreeding, suggesting that the mutant allele is probably not particularly rare in the population under our surveillance.

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