scholarly journals Independence of Angiotensin II-Induced MAP Kinase Activation from Angiotensin Type 1 Receptor Internalization in Clone 9 Hepatocytes

2002 ◽  
Vol 16 (3) ◽  
pp. 610-620 ◽  
Author(s):  
Bukhtiar H. Shah ◽  
J. Alberto Olivares-Reyes ◽  
Akin Yesilkaya ◽  
Kevin J. Catt
Keyword(s):  
Angiotensin Ii ◽  
Map Kinase ◽  
Receptor Internalization ◽  
Kinase Activation ◽  
Angiotensin Type

Angiotensin II type 1 receptor-mediated activation of Ras in cultured rat vascular smooth muscle cells

1996 ◽  
Vol 271 (2) ◽  
pp. H595-H601 ◽  
Author(s):  
M. Okuda ◽  
Y. Kawahara ◽  
M. Yokoyama
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Smooth Muscle Cells ◽  
Map Kinase ◽  
Vascular Smooth Muscle Cells ◽  
Ang Ii ◽  
Kinase Activation ◽  
Ras Activation ◽  
Fos Expression

Angiotensin II (ANG II), a potent growth-promoting factor of vascular smooth muscle cells (VSMC), induces activation of mitogen-activated protein (MAP) kinases and subsequent expression of the c-fos protooncogene in VSMC. However, it remains obscure whether ANG II induces activation of the ras protooncogene product (Ras), and if it does, whether Ras is involved in signaling from the ANG II receptor to the MAP kinase pathway in VSMC. In cultured VSMC, ANG II activated Ras comparably to epidermal growth factor. ANG II-induced Ras activation was detectable within 1 min and maximal at 2–5 min. The ANG II type 1 (AT1) receptor antagonist, CV-11974, completely inhibited this reaction. Pertussis toxin treatment of VSMC inhibited ANG II-induced Ras activation by approximately 70% but had no effect on ANG II-induced MAP kinase activation and c-fos expression. These results indicate that ANG II activates Ras via AT1 receptors, which are predominantly linked to a G protein of the Gi subfamily in VSMC1 and suggest that Ras activation may not be a prerequisite for ANG II-induced MAP kinase activation and c-fos expression in this cell type.

scholarly journals Angiotensin II modulates amphetamine‐induced glial and brain vascular responses, and attention deficit via angiotensin type 1 receptor: Evidence from brain regional sensitivity to amphetamine

2020 ◽  
Vol 51 (4) ◽  
pp. 1026-1041 ◽  
Author(s):  
Natalia Andrea Marchese ◽  
Victoria Belén Occhieppo ◽  
Osvaldo Martin Basmadjian ◽  
Brenda Solange Casarsa ◽  
Gustavo Baiardi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Attention Deficit ◽  
Vascular Responses ◽  
Angiotensin Type

scholarly journals Renal Angiotensin Type 2 Receptors Mediate Natriuresis Via Angiotensin III in the Angiotensin II Type 1 Receptor–Blocked Rat

Hypertension ◽  
2006 ◽  
Vol 47 (3) ◽  
pp. 537-544 ◽  
Author(s):  
Shetal H. Padia ◽  
Nancy L. Howell ◽  
Helmy M. Siragy ◽  
Robert M. Carey
Keyword(s):  
Angiotensin Ii ◽  
Angiotensin Iii ◽  
Angiotensin Type

scholarly journals Mechanism of Angiotensin II-induced Superoxide Production in Cells Reconstituted with Angiotensin Type 1 Receptor and the Components of NADPH Oxidase

2007 ◽  
Vol 283 (1) ◽  
pp. 255-267 ◽  
Author(s):  
Hyun Choi ◽  
Thomas L. Leto ◽  
László Hunyady ◽  
Kevin J. Catt ◽  
Yun Soo Bae ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Nadph Oxidase ◽  
Superoxide Production ◽  
Angiotensin Type ◽  
In Cells

Angiotensin II promotes cardiac differentiation of embryonic stem cells via angiotensin type 1 receptor

2013 ◽  
Vol 86 (1-2) ◽  
pp. 23-29 ◽  
Author(s):  
Liyuan Wu ◽  
Zhuqing Jia ◽  
Lihui Yan ◽  
Weiping Wang ◽  
Jiaji Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Angiotensin Ii ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cardiac Differentiation ◽  
Angiotensin Type
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