scholarly journals Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

2009 ◽  
Vol 23 (11) ◽  
pp. 1935-1935
Author(s):  
Samantha Butts ◽  
Harold Riethman ◽  
Sarah Ratcliffe ◽  
Alka Shaunik ◽  
Christos Coutifaris ◽  
...  
Keyword(s):  
Telomere Length ◽  
Telomerase Activity ◽  
Ovarian Insufficiency

scholarly journals Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

2009 ◽  
Vol 94 (12) ◽  
pp. 4835-4843 ◽  
Author(s):  
Samantha Butts ◽  
Harold Riethman ◽  
Sarah Ratcliffe ◽  
Alka Shaunik ◽  
Christos Coutifaris ◽  
...  
Keyword(s):  
Telomere Length ◽  
Telomerase Activity ◽  
Ovarian Insufficiency

638: Clinical relevance of telomere length and telomerase activity in colorectal cancer

2014 ◽  
Vol 50 ◽  
pp. S152
Author(s):  
C. De Juan Chocano ◽  
T. Fernández-Marcelo ◽  
I. Pascua ◽  
J. Head ◽  
A. Sánchez-Pernaute ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Telomere Length ◽  
Clinical Relevance ◽  
Telomerase Activity

Telomere length and telomerase activity: effect of ageing on human NK cells

2003 ◽  
Vol 124 (4) ◽  
pp. 403-408 ◽  
Author(s):  
Erminia Mariani ◽  
Alessandra Meneghetti ◽  
Ivan Formentini ◽  
Simona Neri ◽  
Luca Cattini ◽  
...  
Keyword(s):  
Nk Cells ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Activity Effect

Expression of Telomerase RNA, Telomerase Activity, and Telomere Length in Human Gliomas

1997 ◽  
Vol 239 (3) ◽  
pp. 830-834 ◽  
Author(s):  
Ken Morii ◽  
Ryuichi Tanaka ◽  
Kiyoshi Onda ◽  
Itaru Tsumanuma ◽  
Jyunichi Yoshimura
Keyword(s):  
Telomere Length ◽  
Telomerase Activity ◽  
Telomerase Rna ◽  
Human Gliomas

scholarly journals Telomere Length in Valve Tissue Is Shorter in Individuals With Aortic Stenosis and in Calcified Valve Areas

2021 ◽  
Vol 9 ◽  
Author(s):  
Ilona Saraieva ◽  
Athanase Benetos ◽  
Carlos Labat ◽  
Anders Franco-Cereceda ◽  
Magnus Bäck ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Aortic Valves ◽  
Fragment Analysis ◽  
Replacement Surgery ◽  
Age Related ◽  
Amplification Protocol ◽  
Telomere Restriction Fragment

BackgroundShort telomere length (TL) is associated with age-related diseases, in particular cardiovascular diseases. However, whether the onset and course of aortic stenosis (AS) is linked to TL in aortic valves remains unknown.ObjectivesTo assess telomere dynamics (TL and telomerase activity) in aortic valves and the possible implication of TL in onset and course of AS.MethodsDNA was extracted from aortic valves obtained from 55 patients (78.2% men; age, 37–79 years), who had undergone replacement surgery due to AS (AS group, n = 32), aortic valve regurgitation and aortic dilation (Non-AS group, n = 23). TL was measured by telomere restriction fragment analysis (TRF) in calcified and non-calcified aortic valve areas. Telomerase activity was evaluated using telomerase repeat amplification protocol (TRAP) in protein extracts from non-calcified and calcified areas of valves obtained from 4 additional patients (50% men; age, 27–70 years).ResultsTL was shorter in calcified aortic valve areas in comparison to non-calcified areas (n = 31, 8.58 ± 0.73 kb vs. 8.12 ± 0.75 kb, p < 0.0001), whereas telomerase activity was not detected in any of those areas. Moreover, patients from AS group displayed shorter telomeres in non-calcified areas than those from the Non-AS group (8.40 ± 0.64 kb vs. 8.85 ± 0.65, p = 0.01).ConclusionsShort telomeres in aortic valves may participate in the development of AS, while concurrently the calcification process seems to promote further local decrease of TL in calcified areas of valves.

Sign in / Sign up

Export Citation Format

Share Document