External environmental agents influence telomere length and telomerase activity by modulating internal cellular processes: Implications in human aging

2021 ◽  
Vol 85 ◽  
pp. 103633
Author(s):  
Stina George Fernandes ◽  
Rebecca Dsouza ◽  
Ekta Khattar
Keyword(s):  
Telomere Length ◽  
Telomerase Activity ◽  
Human Aging ◽  
Cellular Processes ◽  
Environmental Agents

638: Clinical relevance of telomere length and telomerase activity in colorectal cancer

2014 ◽  
Vol 50 ◽  
pp. S152
Author(s):  
C. De Juan Chocano ◽  
T. Fernández-Marcelo ◽  
I. Pascua ◽  
J. Head ◽  
A. Sánchez-Pernaute ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Telomere Length ◽  
Clinical Relevance ◽  
Telomerase Activity

Telomere length and telomerase activity: effect of ageing on human NK cells

2003 ◽  
Vol 124 (4) ◽  
pp. 403-408 ◽  
Author(s):  
Erminia Mariani ◽  
Alessandra Meneghetti ◽  
Ivan Formentini ◽  
Simona Neri ◽  
Luca Cattini ◽  
...  
Keyword(s):  
Nk Cells ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Activity Effect

Expression of Telomerase RNA, Telomerase Activity, and Telomere Length in Human Gliomas

1997 ◽  
Vol 239 (3) ◽  
pp. 830-834 ◽  
Author(s):  
Ken Morii ◽  
Ryuichi Tanaka ◽  
Kiyoshi Onda ◽  
Itaru Tsumanuma ◽  
Jyunichi Yoshimura
Keyword(s):  
Telomere Length ◽  
Telomerase Activity ◽  
Telomerase Rna ◽  
Human Gliomas

scholarly journals Correlation of Telomere Length and Telomerase Activity with Occult Ovarian Insufficiency

2009 ◽  
Vol 23 (11) ◽  
pp. 1935-1935
Author(s):  
Samantha Butts ◽  
Harold Riethman ◽  
Sarah Ratcliffe ◽  
Alka Shaunik ◽  
Christos Coutifaris ◽  
...  
Keyword(s):  
Telomere Length ◽  
Telomerase Activity ◽  
Ovarian Insufficiency

scholarly journals Telomere Length in Valve Tissue Is Shorter in Individuals With Aortic Stenosis and in Calcified Valve Areas

2021 ◽  
Vol 9 ◽  
Author(s):  
Ilona Saraieva ◽  
Athanase Benetos ◽  
Carlos Labat ◽  
Anders Franco-Cereceda ◽  
Magnus Bäck ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Stenosis ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Aortic Valves ◽  
Fragment Analysis ◽  
Replacement Surgery ◽  
Age Related ◽  
Amplification Protocol ◽  
Telomere Restriction Fragment

BackgroundShort telomere length (TL) is associated with age-related diseases, in particular cardiovascular diseases. However, whether the onset and course of aortic stenosis (AS) is linked to TL in aortic valves remains unknown.ObjectivesTo assess telomere dynamics (TL and telomerase activity) in aortic valves and the possible implication of TL in onset and course of AS.MethodsDNA was extracted from aortic valves obtained from 55 patients (78.2% men; age, 37–79 years), who had undergone replacement surgery due to AS (AS group, n = 32), aortic valve regurgitation and aortic dilation (Non-AS group, n = 23). TL was measured by telomere restriction fragment analysis (TRF) in calcified and non-calcified aortic valve areas. Telomerase activity was evaluated using telomerase repeat amplification protocol (TRAP) in protein extracts from non-calcified and calcified areas of valves obtained from 4 additional patients (50% men; age, 27–70 years).ResultsTL was shorter in calcified aortic valve areas in comparison to non-calcified areas (n = 31, 8.58 ± 0.73 kb vs. 8.12 ± 0.75 kb, p < 0.0001), whereas telomerase activity was not detected in any of those areas. Moreover, patients from AS group displayed shorter telomeres in non-calcified areas than those from the Non-AS group (8.40 ± 0.64 kb vs. 8.85 ± 0.65, p = 0.01).ConclusionsShort telomeres in aortic valves may participate in the development of AS, while concurrently the calcification process seems to promote further local decrease of TL in calcified areas of valves.

scholarly journals Telomere biology and metabolic disorders: the role of insulin resistance and type 2 diabetes

2020 ◽  
Vol 66 (4) ◽  
pp. 35-44
Author(s):  
Ekaterina N. Dudinskaya ◽  
Olga N. Tkacheva ◽  
Natalia V. Brailova ◽  
Irina D. Strazhesko ◽  
Marina V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Carbohydrate Metabolism ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Cellular Aging ◽  
The Mean ◽  
Telomere Biology

BACKGROUND: Insulin resistance accelerates the aging process, but its speed depends on the individual characteristics of the metabolism. One of the reasons for the different aging rates in individuals with insulin resistance is the initially different “genetic protection” of cells, which many scientists associate with replicative cellular aging.AIMS: to study the relationship between the state of carbohydrate metabolism and markers of replicative cell aging in individuals with different sensitivity to insulin.MATERIALS AND METHODS: The observation study included 305 patients. The parameters of glucose metabolism and telomere biology were studied.RESULTS: The mean age of the patients was 51.5±13.3 years. Patients were divided into three groups depending on presence of insulin resistance: healthy, with insulin resistance and with type 2 diabetes. The mean age of healthy patients was 48.82±13.87 years, in insulin resistance group — 53.04±12.8, in 2 diabetes mellitus — 58.4±7.90. The median telomere length was 9.76. The median telomerase activity was 0.48. Both telomere length and telomerase activity progressively decrease as insulin resistance increases. In patients with diabetes, short telomere lengths and low telomerase activity predominated. The insulin resistance index has the greatest impact on the risk of detecting “short” telomeres. In patients with insulin resistance, an increase in glycated hemoglobin increases the likelihood of detecting short telomeres by 2.4 times, and in diabetes mellitus by 4.26 times, an increase in fasting plasma glucose by 90%, and an increase in HOMA-IR by 35%. An increase in insulin resistance increases the risk of detecting «low» telomerase activity by 53% and the risk of detecting «very low» telomerase activity by 92%. A decrease in synsulin resistance increases the chance of increasing telomerase activity to «very high» by 51%.CONCLUSION: Shorter telomeres are associated with more pronounced disorders of carbohydrate metabolism and a higher degree of insulin resistance. Further studies of metabolic status are necessary to personalize their lifestyle and treatment goals.

scholarly journals Relationship Between Leukocyte Telomere Length, Telomerase Activity, and Hippocampal Volume in Early Aging

2014 ◽  
Vol 71 (7) ◽  
pp. 921 ◽  
Author(s):  
Emily G. Jacobs ◽  
Elissa S. Epel ◽  
Jue Lin ◽  
Elizabeth H. Blackburn ◽  
Natalie L. Rasgon
Keyword(s):  
Telomere Length ◽  
Hippocampal Volume ◽  
Telomerase Activity ◽  
Leukocyte Telomere Length ◽  
Early Aging

Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages

2016 ◽  
Vol 69 (4) ◽  
pp. 551-554 ◽  
Author(s):  
Jayant K. Rane ◽  
Sarah Greener ◽  
Fiona M. Frame ◽  
Vincent M. Mann ◽  
Matthew S. Simms ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Telomere Length ◽  
Telomerase Activity ◽  
Prostatic Hyperplasia ◽  
Luminal Cell ◽  
Cell Lineages
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