scholarly journals Risk factors for possible REM sleep behavior disorder

Neurology ◽  
2018 ◽  
Vol 92 (5) ◽  
pp. e475-e485 ◽  
Author(s):  
Chun Yao ◽  
Seyed-Mohammad Fereshtehnejad ◽  
Mark R. Keezer ◽  
Christina Wolfson ◽  
Amélie Pelletier ◽  
...  
Keyword(s):  
Risk Factors ◽  
Psychological Distress ◽  
Rem Sleep ◽  
Antidepressant Treatment ◽  
Strong Association ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
National Cohort ◽  
Male Sex

ObjectiveTo assess sociodemographic, socioeconomic, and clinical correlates of idiopathic REM sleep behavior disorder (RBD) in a 30,097-person national cohort.MethodsParticipants 45 to 85 years of age in Canada were collected as part of the Canadian Longitudinal Study on Aging. Possible RBD (pRBD) was screened with the REM Sleep Behavior Disorder Single-Question Screen, a questionnaire with 94% specificity and 87% sensitivity. To improve diagnostic accuracy, those screening positive for apnea or non-REM parasomnia (young-onset pRBD) and those self-reporting dementia or Parkinson disease were excluded. A series of sociodemographic, lifestyle, and mental health variables were analyzed cross-sectionally. Potential correlates were assessed via multivariable logistic regression.ResultsOf 30,097 participants, 958 (3.2%) were identified as having pRBD. Male sex (odds ratio [OR] 2.09, 95% confidence interval [CI] 1.78–2.44) and lower education (OR 0.95, 95% CI 0.92–0.98) were associated with pRBD. Participants with pRBD had smoked more (pack-years OR 1.01, 95% CI 1.00–1.01) and were more likely to be moderate to heavy drinkers (OR 1.25, 95% CI 1.04–1.51). There was a strong association between pRBD and self-reported antidepressant treatment for depression (OR 2.77, 95% CI 2.23–3.45), psychological distress (OR 1.61, 95% CI 1.44–1.80), mental illness (OR 2.09, 95% CI 1.75–2.49), and posttraumatic stress disorder (OR 2.68, 95% CI 1.97–3.65).ConclusionsOur study replicated previous reported associations between pRBD and smoking, low education, and male sex and found previously unreported links with alcohol use and psychological distress. Risk factors for pRBD differ from those previously defined for neurodegenerative synucleinopathies.

scholarly journals P1-324: APOE ε4 AND REM SLEEP BEHAVIOR DISORDER AS RISK FACTORS FOR SUNDOWN SYNDROME IN ALZHEIMER'S DISEASE

2019 ◽  
Vol 15 ◽  
pp. P368-P368
Author(s):  
Jung Min Pyun ◽  
Min Ju Kang ◽  
Jeewon Suh ◽  
Moon-ku Han ◽  
Young Ho Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior ◽  
Apoe Ε4

scholarly journals Risk factors for possible REM sleep behavior disorders

Neurology ◽  
2020 ◽  
Vol 95 (16) ◽  
pp. e2214-e2224
Author(s):  
Hui Zhang ◽  
Zhuqin Gu ◽  
Chun Yao ◽  
Yanning Cai ◽  
Yuan Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Rem Sleep ◽  
Positive Family History ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Multivariable Logistic Regression Analysis ◽  
Co Poisoning ◽  
Sleep Behavior ◽  
History Of

ObjectiveTo explore the risk factors for idiopathic REM sleep behavior disorder (RBD) in a community population in Beijing.MethodsParticipants aged 55 years and above were recruited from the Beijing Longitudinal Study on Aging II cohort. We identified individuals with possible RBD (pRBD) using the validated RBD Questionnaire–Hong Kong in 2010. A series of environmental, lifestyle, and other potential risk factors were assessed via standardized questionnaires in 2009. Multivariable logistic regression analysis was performed to investigate the association between the studied factors and pRBD.ResultsOf 7,225 participants who were free of parkinsonism and dementia, 219 (3.0%) individuals were considered as having pRBD. Participants with pRBD reported more nonmotor and motor symptoms of Parkinson disease (PD) with adjusted odds ratios (ORs) ranging from 1.10 to 4.40. Participants with pRBD were more likely to report a family history of parkinsonism or dementia (OR 3.03, 95% confidence interval [CI] 1.23–7.46). There was a significant association between pRBD and self-reported hyperlipidemia (OR 1.51, 95% CI 1.09–2.10), ever smoking (OR 1.79, 95% CI 1.20–2.65), prior carbon monoxide (CO) poisoning (OR 2.30, 95% CI 1.39–3.83), and nonoccupational exposure to pesticides (OR 2.21, 95% CI 1.40–3.50).ConclusionOur study replicated previously reported associations between pRBD and hyperlipidemia, smoking, pesticide exposure, and several prodromal PD symptoms. We also found previously unreported links with a positive family history of parkinsonism or dementia and CO poisoning. Risk factor profiles for pRBD partially resemble those defined for PD, but also differ in distinct ways.

Hiding in plain sight: Risk factors for REM sleep behavior disorder

Neurology ◽  
2012 ◽  
Vol 79 (5) ◽  
pp. 402-403 ◽  
Author(s):  
S. S. Sullivan ◽  
C. H. Schenck ◽  
C. Guilleminault
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

APOE ɛ4 and REM Sleep Behavior Disorder as Risk Factors for Sundown Syndrome in Alzheimer’s Disease

2019 ◽  
Vol 69 (2) ◽  
pp. 521-528 ◽  
Author(s):  
Jung-Min Pyun ◽  
Min Ju Kang ◽  
Younghwa Yun ◽  
Young Ho Park ◽  
SangYun Kim
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

scholarly journals Risk factors for probable REM sleep behavior disorder

Neurology ◽  
2016 ◽  
Vol 86 (14) ◽  
pp. 1306-1312 ◽  
Author(s):  
Janice C. Wong ◽  
Junjuan Li ◽  
Milena Pavlova ◽  
Shuohua Chen ◽  
Aiping Wu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

scholarly journals Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study

Neurology ◽  
2012 ◽  
Vol 79 (5) ◽  
pp. 428-434 ◽  
Author(s):  
R. B. Postuma ◽  
J. Y. Montplaisir ◽  
A. Pelletier ◽  
Y. Dauvilliers ◽  
W. Oertel ◽  
...  
Keyword(s):  
Risk Factors ◽  
Environmental Risk ◽  
Rem Sleep ◽  
Case Control Study ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Case Control ◽  
Environmental Risk Factors ◽  
Sleep Behavior ◽  
Control Study

Risk factors for phenoconversion in REM sleep behavior disorder

2022 ◽  
Author(s):  
Hui Zhang ◽  
Alex Iranzo ◽  
Birgit Högl ◽  
Isabelle Arnulf ◽  
Luigi Ferini‐Strambi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Sleep Behavior

Cardiovascular Risk Factors and Phenoconversion to Neurodegenerative Synucleinopathies in Idiopathic REM Sleep Behavior Disorder

2022 ◽  
pp. 1-7
Author(s):  
Sheida Zolfaghari ◽  
Natalia Lewandowski ◽  
Amelie Pelletier ◽  
Seyed Ali Naeimi ◽  
Jean-François Gagnon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Rem Sleep ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Metabolic Risk ◽  
Sleep Behavior ◽  
History Of ◽  
Atherosclerotic Risk Factors

Several studies have suggested that atherosclerotic diseases and diabetes may be risk factors for α-synucleinopathies. This prospective cohort study evaluated whether cardiovascular diseases and metabolic risk factors alter the rate or type of phenoconversion from idiopathic/isolated REM sleep behavior disorder (iRBD) to parkinsonism or dementia. Polysomnography-confirmed iRBD patients recruited between 2004 and 2020 were followed annually. Baseline history of cardiovascular disorders, hypertension, hypercholesterolemia, and diabetes were compared among patients who developed outcomes versus those who remained outcome-free. No atherosclerotic risk factors were associated with development of α-synucleinopathies. Patients with hypercholesterolemia were somewhat more likely to develop dementia with Lewy bodies rather than Parkinson’s disease.

scholarly journals Normative and isolated rapid eye movement sleep without atonia in adults without REM sleep behavior disorder

SLEEP ◽  
2019 ◽  
Vol 42 (10) ◽  
Author(s):  
John C Feemster ◽  
Youngsin Jung ◽  
Paul C Timm ◽  
Sarah M Westerland ◽  
Thomas R Gossard ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Older Men ◽  
Sleep Behavior ◽  
Rem Sleep Without Atonia ◽  
Rem Atonia ◽  
Male Sex ◽  
Anterior Tibialis

Abstract Study Objectives Values for normative REM sleep without atonia (RSWA) remain unclear. Older age and male sex are associated with greater RSWA, and isolated elevated RSWA has been reported. We aimed to describe normative RSWA and characterize isolated RSWA frequency in adults without REM sleep behavior disorder (RBD). Methods We visually quantified phasic, “any,” and tonic RSWA in the submentalis (SM) and anterior tibialis (AT) muscles, and the automated Ferri REM Atonia Index during polysomnography in adults without RBD aged 21–88. We calculated RSWA percentiles across age and sex deciles and compared RSWA in older (≥ 65) versus younger (<65) men and women. Isolated RSWA (exceeding diagnostic RBD cutoffs, or >95th percentile) frequency was also determined. Results Overall, 95th percentile RSWA percentages were SM phasic, any, tonic = 8.6%, 9.1%, 0.99%; AT phasic and “any” = 17.0%; combined SM/AT phasic, “any” = 22.3%, 25.5%; and RAI = 0.85. Most phasic RSWA burst durations were ≤1.0 s (85th percentiles: SM = 1.07, AT = 0.86 seconds). Older men had significantly higher AT RSWA than older women and younger patients (all p < 0.04). Twenty-nine (25%, 18 men) had RSWA exceeding the cohort 95th percentile, while 17 (14%, 12 men) fulfilled diagnostic cutoffs for phasic or automated RBD RSWA thresholds. Conclusions RSWA levels are highest in older men, mirroring the demographic characteristics of RBD, suggesting that older men frequently have altered REM sleep atonia control. These data establish normative adult RSWA values and thresholds for determination of isolated RSWA elevation, potentially aiding RBD diagnosis and discussions concerning incidental RSWA in clinical sleep medicine practice.

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