Author Response: Kidney Function, Kidney Function Decline, and the Risk of Dementia in Older Adults

Neurology ◽  
2021 ◽  
Vol 97 (20) ◽  
pp. 967-967
Author(s):  
Hong Xu ◽  
Sara Garcia-Ptacek ◽  
Bengt Lindholm ◽  
Maria Eriksdotter ◽  
Juan Jesus Carrero
Keyword(s):  
Older Adults ◽  
Kidney Function ◽  
Author Response ◽  
Kidney Function Decline

scholarly journals Rate of Kidney Function Decline in Older Adults: A Comparison Using Creatinine and Cystatin C

2009 ◽  
Vol 30 (3) ◽  
pp. 171-178 ◽  
Author(s):  
Michael G. Shlipak ◽  
Ronit Katz ◽  
Bryan Kestenbaum ◽  
Linda F. Fried ◽  
Anne B. Newman ◽  
...  
Keyword(s):  
Older Adults ◽  
Kidney Function ◽  
Cystatin C ◽  
Kidney Function Decline

scholarly journals Rapid Kidney Function Decline and Mortality Risk in Older Adults

2008 ◽  
Vol 168 (20) ◽  
pp. 2212 ◽  
Author(s):  
Dena E. Rifkin ◽  
Michael G. Shlipak ◽  
Ronit Katz ◽  
Linda F. Fried ◽  
David Siscovick ◽  
...  
Keyword(s):  
Older Adults ◽  
Kidney Function ◽  
Mortality Risk ◽  
Kidney Function Decline

scholarly journals Fibroblast Growth Factor 23: A Biomarker of Kidney Function Decline

2018 ◽  
Vol 47 (4) ◽  
pp. 242-250 ◽  
Author(s):  
David A. Drew ◽  
Ronit Katz ◽  
Stephen Kritchevsky ◽  
Joachim H. Ix ◽  
Michael G. Shlipak ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Kidney Function ◽  
Fibroblast Growth Factor 23 ◽  
Community Dwelling ◽  
Fibroblast Growth ◽  
Fgf 23 ◽  
Kidney Function Decline

Background: Fibroblast growth factor 23 (FGF-23) is a hormone that regulates phosphorus levels and vitamin D metabolism. Previous studies have shown FGF-23 to be a risk factor for incident end-stage renal disease; however, there are less data on the association of FGF-23 with earlier kidney-related outcomes. Methods: Serum FGF-23 was assayed using an intact ELISA assay in 2,496 participants of the Healthy Aging and Body Composition Study, a cohort of well-functioning older adults. Kidney function was estimated by assaying cystatin C at baseline and years 3 and 10. The associations between FGF-23 and decline in kidney function (defined by estimated glomerular filtration rate (eGFR) decline ≥30% or ≥3 mL/min/year) and incident chronic kidney disease (CKD; incident eGFR <60 mL/min/1.73 m2 and ≥1 mL/min/year decline) were evaluated. Models were adjusted for demographics, baseline eGFR, urine albumin/creatinine ratio, comorbidity, and serum calcium, phosphorus, 25(OH) vitamin D and parathyroid hormone. Results: The mean (SD) age was 75 (3) years, with 52% female and 38% black. There were 405 persons with 30% decline, 702 with >3 mL/min/year decline, and 536 with incident CKD. In fully adjusted continuous models, doubling of FGF-23 concentrations was not associated with kidney function decline (OR [95% CI] = 0.98 [0.82–1.19] for ≥30% decline and OR 1.17 [95% CI 1.00–1.37] for ≥3 mL/min/year decline), or incident CKD (incident rate ratio [IRR] 1.05 [95% CI 0.91–1.22]). In adjusted quartile analysis, the highest quartile of FGF-23 was significantly associated with incident CKD (IRR 1.27 [95% CI 1.02–1.58] for highest vs. lowest quartile). Conclusion: Higher FGF-23 concentrations were not consistently associated with decline in kidney function or incident CKD in community-dwelling older adults.

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