Infliximab to Treat Severe Paradoxical Reaction in HIV-Negative Tuberculous Meningoencephalitis

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000013047
Author(s):  
Tiphaine Goulenok ◽  
Augustin Gaudemer ◽  
Diane Rouzaud ◽  
Marie-Paule Chauveheid ◽  
Jean Francois Alexandra ◽  
...  
Keyword(s):  
Paradoxical Reaction ◽  
Hiv Negative

scholarly journals Paradoxical reaction (PR) in HIV negative patients with tuberculosis: Case series

2016 ◽  
Vol 45 ◽  
pp. 406-407
Author(s):  
A. Rajendra ◽  
K. Sabnis ◽  
J.S. Michael ◽  
P. Rupali
Keyword(s):  
Case Series ◽  
Paradoxical Reaction ◽  
Tuberculosis Case ◽  
Hiv Negative

scholarly journals Disseminated tuberculosis in a pregnant HIV negative woman with 12 weeks of pregnancy obtained through in vitro fertilization

2015 ◽  
Vol 18 (4) ◽  
pp. 164-170
Author(s):  
Cristiana Cristea ◽  
◽  
Cornel Popescu ◽  
Mihaela Voicu ◽  
Stela Mereuţă ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Extrapulmonary Tuberculosis ◽  
Antituberculous Therapy ◽  
Paradoxical Reaction ◽  
Vitro Fertilization ◽  
Therapy Initiation ◽  
Negative Woman ◽  
Inflammatory Syndrome ◽  
Hiv Negative

Information on the outcome of extrapulmonary tuberculosis in pregnant women is limited. We present particular clinical and outcome aspects in a pregnant HIV negative woman (with pregnancy after in vitro fertilization) with tuberculosis at multiple extrapulmonary sites. In addition, we will describe the paradoxical reaction with appearance of cerebral tuberculomas after 7 months of antituberculous therapy initiation, most probably in the context of a immune reconstitution inflammatory syndrome (IRIS).

scholarly journals Paradoxical reaction in HIV-negative tuberculous meningitis patients with spinal involvement

2019 ◽  
Vol 79 ◽  
pp. 104-108 ◽  
Author(s):  
Yin Liu ◽  
Zheng Wang ◽  
Guang Yao ◽  
Yuying Lu ◽  
Zhongyang Hu ◽  
...  
Keyword(s):  
Tuberculous Meningitis ◽  
Paradoxical Reaction ◽  
Spinal Involvement ◽  
Hiv Negative

scholarly journals A Case of Multilevel Airway Obstruction Secondary to Paradoxical Reaction to Anti TB Drugs in a Non HIV Patient with Tracheobronchial and Cervical Tuberculous Lymphadenitis

2021 ◽  
pp. 29-32
Author(s):  
A. Kanivannen ◽  
A. Suhana ◽  
P. Chenthilnathan ◽  
S. Alazzawi ◽  
S. Avatar
Keyword(s):  
Case Report ◽  
Airway Obstruction ◽  
Young Male ◽  
Tuberculous Lymphadenitis ◽  
Paradoxical Reaction ◽  
Negative Patient ◽  
Antituberculous Drugs ◽  
Hiv Negative

A case report of a young male diagnosed as cervical tuberculous lymphadenitis presenting with rapidly enlarging neck nodes causing airway obstructing secondary to paradoxical reaction to antituberculous drugs. This phenomenon is rare in HIV negative patient. He also had myriad of symptoms and multilevel obstructions. In this case report we discuss the presentation of patient to our center with the management and possible pitfalls. 

scholarly journals Paradoxical reactions during Antituberculosis therapy - A single-center prospective analysis

2015 ◽  
Vol 2 (2) ◽  
pp. 32-35
Author(s):  
Sanae Hammi ◽  
Naima Zimed ◽  
Khalid Bouti ◽  
Jamal Eddine Bourkadi
Keyword(s):  
Lymph Node ◽  
Infectious Diseases ◽  
Clinical Microbiology ◽  
Tuberculous Lymphadenitis ◽  
Paradoxical Reaction ◽  
Paradoxical Response ◽  
Antituberculosis Therapy ◽  
Tuberculous Abscess ◽  
Lymph Node Tuberculosis ◽  
Hiv Negative

[1] Hawkey CR, Yap T, Pereira J, Moore DA, Davidson RN, Pasvol G, et al. Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis. Clinical infectious diseases. 2005;40(9):1368-71. [2] Breton G. Syndrome inflammatoire de reconstitution immune (IRIS) associé à la tuberculose. Journal des Anti-infectieux. 2012;14(4):180-5. [3] Cheng V, Ho P, Lee R, Chan K, Woo P, Lau S, et al. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. European Journal of Clinical Microbiology and Infectious Diseases. 2002;21(11):803-9. [4] Al-Majed S. Study of paradoxical response to chemotherapy in tuberculous pleural effusion. Respiratory medicine. 1996;90(4):211-4. [5] Campbell I, Dyson A. Lymph node tuberculosis: a comparison of various methods of treatment. Tubercle. 1977;58(4):171-9. [6] Memish Z, Mah M, Mahmood SA, Bannatyne R, Khan M. Clinico‐diagnostic experience with tuberculous lymphadenitis in Saudi Arabia. Clinical microbiology and infection. 2000;6(3):137-41. [7] Choremis C, Padiatellis C, ZOU MLD, Yannakos D. Transitory exacerbation of fever and roentgenographic findings during treatment of tuberculosis in children. American review of tuberculosis. 1955;72(4):527. [8] Orlovic D, Smego J. Paradoxical tuberculous reactions in HIV-infected patients. The International Journal of Tuberculosis and Lung Disease. 2001;5(4):370-5. [9] Park I-S, Son D, Lee C, Park JE, Lee J-S, Cheong M-H, et al. Severe paradoxical reaction requiring tracheostomy in a human immunodeficiency virus (HIV)-negative patient with cervical lymph node tuberculosis. Yonsei medical journal. 2008;49(5):853-6. [10] Martinez V, Bricaire F. Réactions paradoxales. La Presse Médicale. 2006;35(1):1753-6. [11] Narita M, Ashkin D, Hollender ES, Pitchenik AE. Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. American journal of respiratory and critical care medicine. 1998;158(1):157-61. [12] Vidal CG, Garau J. Systemic steroid treatment of paradoxical upgrading reaction in patients with lymph node tuberculosis. Clinical infectious diseases. 2005;41(6):915-6. [13] Rakotoarivelo R, Vandenhende M-A, Michaux C, Morlat P, Bonnet F. Réactions paradoxales sous traitement antituberculeux chez des personnes non infectées par le VIH: quatre nouvelles observations et revue de la littérature. La Revue de médecine interne. 2013;34(4):202-8. [14] Cheng V, Yam W, Woo P, Lau S, Hung I, Wong S, et al. Risk factors for development of paradoxical response during antituberculosis therapy in HIV-negative patients. European Journal of Clinical Microbiology and Infectious Diseases. 2003;22(10):597-602. [15] Rao GP, Nadh BR, Hemaratnan A, Srinivas T, Reddy PK. Paradoxical progression of tuberculous lesions during chemotherapy of central nervous system tuberculosis: report of four cases. Journal of neurosurgery. 1995;83(2):359-62. [16] Fontanilla J-M, Barnes A, Von Reyn CF. Current diagnosis and management of peripheral tuberculous lymphadenitis. Clinical Infectious Diseases. 2011;53(6):555-62. [17] Guinchard A-C, Pasche P. Lymphadénite tuberculeuse cervicale et réaction paradoxale: diagnostic et traitement. ORL. 2012;356(34):1860-5. [18] Colebunders R, John L, Huyst V, Kambugu A, Scano F, Lynen L. Syndrome inflammatoire de reconstitution immunitaire de la tuberculose dans les pays à ressources limitées. Int J Tuberc Lung Dis. 2006;10(9):946-53. [19] Malone J, Paparello S, Rickman L, Wagner K, Monahan B, Oldfield E. Intracranial tuberculoma developing during therapy for tuberculous meningitis. Western Journal of Medicine. 1990;152(2):188. [20] Valdez LM, Schwab P, Okhuysen PC, Rakita RM. Paradoxical subcutaneous tuberculous abscess. Clinical infectious diseases. 1997;24(4):734-. [21] Bouchez B, Arnott G, Colover J. Paradoxical expansion of intracranial tuberculomas during chemotherapy. The Lancet. 1984;324(8400):470-1. [22] [Recommendations of the French Language Pneumology Society for tuberculosis management in France: consensus conference. Nice, France, 23 January 2004]. Revue des maladies respiratoires. 2004;21(3 Pt 2):S3-104. [23] Rabar D, Issartel B, Petiot P, Boibieux A, Chidiac C, Peyramond D. Tuberculomes et méningoradiculite tuberculeuse d’évolution paradoxale sous traitement. La Presse Médicale. 2005;34(1):32-4. [24] Chambers S, Record C, Hendrickse W, Rudge P, Smith H. Paradoxical expansion of intracranial tuberculomas during chemotherapy. The Lancet. 1984;324(8396):181-4. [25] Safdar A, Brown AE, Kraus DH, Malkin M. Paradoxical reaction syndrome complicating aural infection due to Mycobacterium tuberculosis during therapy. Clinical infectious diseases. 2000;30(3):625-7. [26] Hejazi N, Hassler W. Multiple intracranial tuberculomas with atypical response to tuberculostatic chemotherapy: literature review and a case report. Infection. 1997;25(4):233-9.

Paradoxical reaction in HIV negative tuberculous meningitis

2014 ◽  
Vol 340 (1-2) ◽  
pp. 26-36 ◽  
Author(s):  
Ravindra Kumar Garg ◽  
Hardeep Singh Malhotra ◽  
Neeraj Kumar
Keyword(s):  
Tuberculous Meningitis ◽  
Paradoxical Reaction ◽  
Hiv Negative

HIV und Schwangerschaft

2014 ◽  
Vol 71 (8) ◽  
pp. 498-502
Author(s):  
Vineeta Bansal Zweifel ◽  
Christoph Berger ◽  
David Nadal ◽  
Claudia Grawe
Keyword(s):  
Präventive Maßnahmen ◽  
Hiv Negative

Der Einsatz und Erfolg der kombinierten antiretroviralen Therapie hat dazu geführt, dass heterosexuelle sowie vertikale HIV-Transmissionen nur noch selten vorkommen. HIV-infizierte Frauen werden immer häufiger schwanger und können durch präventive Maßnahmen, v. a. in den industrialisierten Ländern, HIV-negative gesunde Kinder gebären. Im nachfolgenden Artikel gehen wir auf die Bedeutung einer HIV-Infektion und auf die wichtigsten diagnostischen sowie therapeutischen Aspekte in der Schwangerschaft ein.

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