Acute changes in blood glucose affect resistance to ischemic nerve conduction failure

Neurology ◽  
1990 ◽  
Vol 40 (1) ◽  
pp. 107-107 ◽  
Author(s):  
G. J. Parry ◽  
H. Kohzu
Keyword(s):  
Blood Glucose ◽  
Nerve Conduction ◽  
Conduction Failure ◽  
Acute Changes

577-P: Choroidal Thickness Is Dependent on BMI and Acute Changes in Blood Glucose

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 577-P
Author(s):  
SVENJA MEYHOEFER ◽  
BRITTA WILMS ◽  
RODRIGO CHAMORRO ◽  
ANNA-JOSEPHIN PAGELS ◽  
HANS-JÜRGEN GREIN ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Choroidal Thickness ◽  
Acute Changes

Acute changes in blood glucose and their effects on color vision function in diabetes

1993 ◽  
pp. 165-173 ◽  
Author(s):  
Marilyn E. Schneck ◽  
Anthony J. Adams ◽  
Vicki J. Volbrecht ◽  
John L. Linfoot
Keyword(s):  
Blood Glucose ◽  
Color Vision ◽  
Acute Changes ◽  
Vision Function

Acute changes in blood glucose do not alter blood glutathione synthesis in adolescents with poorly controlled type 1 diabetes mellitus

Metabolism ◽  
2012 ◽  
Vol 61 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Dominique Darmaun ◽  
Susan Welch ◽  
Shiela Smith ◽  
Shawn Sweeten ◽  
Nelly Mauras
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Type 1 Diabetes Mellitus ◽  
Glutathione Synthesis ◽  
Acute Changes

No acute effect of high blood glucose on nerve conduction in adolescents with IDDM

1997 ◽  
Vol 35 (2-3) ◽  
pp. 157-161 ◽  
Author(s):  
Lars Hyllienmark ◽  
Johnny Ludvigsson ◽  
Tom Brismar
Keyword(s):  
Blood Glucose ◽  
Nerve Conduction ◽  
Acute Effect ◽  
High Blood Glucose

scholarly journals Rapid fluctuations in glycosylated haemoglobin concentration as related to acute changes in blood glucose

Diabetologia ◽  
1980 ◽  
Vol 19 (4) ◽  
pp. 403-404 ◽  
Author(s):  
J. Ditzel ◽  
P. H. Forsham ◽  
M. Lorenzi
Keyword(s):  
Blood Glucose ◽  
Haemoglobin Concentration ◽  
Glycosylated Haemoglobin ◽  
Acute Changes

Conduction failure and nerve conduction slowing in experimental allergic neuritis induced by P2-specific T-cell lines

1986 ◽  
Vol 19 (1) ◽  
pp. 44-49 ◽  
Author(s):  
Kurt Heininger ◽  
Guido Stoll ◽  
Christopher Linington ◽  
Klaus V. Toyka ◽  
Hartmut Wekerle
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Nerve Conduction ◽  
Experimental Allergic Neuritis ◽  
Conduction Failure ◽  
T Cell Lines ◽  
Experimental Allergic ◽  
Allergic Neuritis

scholarly journals Time course of reversibility of accelerated fibrinogen disappearance in diabetes mellitus: association with intravascular volume shifts

Blood ◽  
1984 ◽  
Vol 63 (1) ◽  
pp. 22-30
Author(s):  
RL Jones ◽  
L Jovanovic ◽  
S Forman ◽  
CM Peterson
Keyword(s):  
Blood Glucose ◽  
Blood Volume ◽  
Volume Expansion ◽  
Time Course ◽  
Diabetic Patients ◽  
Vascular Volume ◽  
Blood Volume Expansion ◽  
Artificial Beta Cell ◽  
Acute Changes ◽  
Osmotic Effects

Accelerated fibrinogen disappearance in diabetic patients is reversible with normalization of blood glucose. To define the time course of this reversal, we measured 125I-fibrinogen disappearance in 19 diabetic patients experiencing acute changes in blood glucose, as monitored and controlled by a microprocessor-controlled closed loop insulin infusion system (artificial beta cell). The data were corrected for blood volume dilutional changes and fit to a model describing two sequential exponential functions and a single exponential function. The sequential model provided the best fit for all but one patient. This indicates that there were two distinct rates of fibrinogen disappearance and suggests that the time course of reversal of accelerated fibrinogen disappearance in diabetic patients is very rapid, if not immediate. Rapid fibrinogen turnover during hyperglycemia was temporally associated with vascular volume changes, reflected as dilutional changes of 51Cr-RBC concentrations. These findings were also associated with an increase in pulse pressure during hyperglycemia, suggesting blood volume expansion due to an osmotic mechanism. The results of this study suggest a picture of vascular volume expansion and contraction, perhaps secondary to the osmotic effects of hyperglycemia. Accelerated fibrinogen turnover associated with these events may be related to increased vascular permeability and/or increased fibrin formation. These events, in concert, may contribute to the initiation and/or propagation of diabetic vascular sequelae.

scholarly journals Evidence of Altered Peripheral Nerve Function in a Rodent Model of Diet-Induced Prediabetes

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 313
Author(s):  
Md Jakir Hossain ◽  
Michael D. Kendig ◽  
Brandon M. Wild ◽  
Tushar Issar ◽  
Arun V. Krishnan ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Nerve Conduction ◽  
Fasting Blood Glucose ◽  
Diabetes Diagnosis ◽  
Tactile Sensitivity ◽  
Nerve Function ◽  
Sprague Dawley ◽  
Fiber Density ◽  
Relevant Model ◽  
Intraepidermal Nerve Fiber Density

Peripheral neuropathy (PN) is a debilitating complication of diabetes that affects >50% of patients. Recent evidence suggests that obesity and metabolic disease, which often precede diabetes diagnosis, may influence PN onset and severity. We examined this in a translationally relevant model of prediabetes induced by a cafeteria (CAF) diet in Sprague–Dawley rats (n = 15 CAF versus n = 15 control). Neuropathy phenotyping included nerve conduction, tactile sensitivity, intraepidermal nerve fiber density (IENFD) and nerve excitability testing, an in vivo measure of ion channel function and membrane potential. Metabolic phenotyping included body composition, blood glucose and lipids, plasma hormones and inflammatory cytokines. After 13 weeks diet, CAF-fed rats demonstrated prediabetes with significantly elevated fasting blood glucose, insulin and impaired glucose tolerance as well as obesity and dyslipidemia. Nerve conduction, tactile sensitivity and IENFD did not differ; however, superexcitability was significantly increased in CAF-fed rats. Mathematical modeling demonstrated this was consistent with a reduction in sodium–potassium pump current. Moreover, superexcitability correlated positively with insulin resistance and adiposity, and negatively with fasting high-density lipoprotein cholesterol. In conclusion, prediabetic rats over-consuming processed, palatable foods demonstrated altered nerve function that preceded overt PN. This work provides a relevant model for pathophysiological investigation of diabetic complications.

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