577-P: Choroidal Thickness Is Dependent on BMI and Acute Changes in Blood Glucose

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 577-P
Author(s):  
SVENJA MEYHOEFER ◽  
BRITTA WILMS ◽  
RODRIGO CHAMORRO ◽  
ANNA-JOSEPHIN PAGELS ◽  
HANS-JÜRGEN GREIN ◽  
...  
Author(s):  
Marilyn E. Schneck ◽  
Anthony J. Adams ◽  
Vicki J. Volbrecht ◽  
John L. Linfoot

Metabolism ◽  
2012 ◽  
Vol 61 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Dominique Darmaun ◽  
Susan Welch ◽  
Shiela Smith ◽  
Shawn Sweeten ◽  
Nelly Mauras

Neurology ◽  
1990 ◽  
Vol 40 (1) ◽  
pp. 107-107 ◽  
Author(s):  
G. J. Parry ◽  
H. Kohzu

Diabetologia ◽  
1980 ◽  
Vol 19 (4) ◽  
pp. 403-404 ◽  
Author(s):  
J. Ditzel ◽  
P. H. Forsham ◽  
M. Lorenzi

Blood ◽  
1984 ◽  
Vol 63 (1) ◽  
pp. 22-30
Author(s):  
RL Jones ◽  
L Jovanovic ◽  
S Forman ◽  
CM Peterson

Accelerated fibrinogen disappearance in diabetic patients is reversible with normalization of blood glucose. To define the time course of this reversal, we measured 125I-fibrinogen disappearance in 19 diabetic patients experiencing acute changes in blood glucose, as monitored and controlled by a microprocessor-controlled closed loop insulin infusion system (artificial beta cell). The data were corrected for blood volume dilutional changes and fit to a model describing two sequential exponential functions and a single exponential function. The sequential model provided the best fit for all but one patient. This indicates that there were two distinct rates of fibrinogen disappearance and suggests that the time course of reversal of accelerated fibrinogen disappearance in diabetic patients is very rapid, if not immediate. Rapid fibrinogen turnover during hyperglycemia was temporally associated with vascular volume changes, reflected as dilutional changes of 51Cr-RBC concentrations. These findings were also associated with an increase in pulse pressure during hyperglycemia, suggesting blood volume expansion due to an osmotic mechanism. The results of this study suggest a picture of vascular volume expansion and contraction, perhaps secondary to the osmotic effects of hyperglycemia. Accelerated fibrinogen turnover associated with these events may be related to increased vascular permeability and/or increased fibrin formation. These events, in concert, may contribute to the initiation and/or propagation of diabetic vascular sequelae.


Diabetes ◽  
1980 ◽  
Vol 29 (8) ◽  
pp. 623-628 ◽  
Author(s):  
D. E. Goldstein ◽  
S. B. Peth ◽  
J. D. England ◽  
R. L. Hess ◽  
J. D. Costa
Keyword(s):  

Retina ◽  
2013 ◽  
Vol 33 (1) ◽  
pp. 160-165 ◽  
Author(s):  
Ahmad A. Alwassia ◽  
Mehreen Adhi ◽  
Jason Y. Zhang ◽  
Caio V. Regatieri ◽  
Adeeb Al-Quthami ◽  
...  

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 85
Author(s):  
Olga E. Makri ◽  
Athina Pallikari ◽  
Konstantinos Kagkelaris ◽  
Stylianos N. Mastronikolis ◽  
Georgios Karanasios ◽  
...  

The present study aims to evaluate and compare the acute effects of tobacco cigarettes (TC) smoking and electronic cigarette (EC) vaping on foveal and choroidal thickness (CT) in young, healthy, dual smokers. Participants underwent four trials: 5 min TC; 5 min EC; 30 min EC; and 60 min nothing (sham trial). Scans before and immediately after each trial were obtained using spectral domain optical coherence tomography with the enhanced depth imaging mode. Changes in central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), and CT at fourother points, 500 μm and 1000 μm temporally and nasally to the fovea, were measured. Forty-seven participants (33 male, 14 female; mean age 24.85 ± 1.57 years) were included. They smoked 13.53 ± 5.27 TCs/day for 6 ± 2.3 years and vaped ECs for the past 2.4 ± 1.08 years. We did not observe any statistically significant change in SFCT, CFT, and CT of the other points after any of the fourtrials. The acute changes in CFT and CT after EC vaping or TC smoking did not differ significantly compared to the sham trial. Smoking and vaping does not seem to result in statistically significant acute alterations in foveal and CT in young, dual smokers.


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