scholarly journals Rapid fluctuations in glycosylated haemoglobin concentration as related to acute changes in blood glucose

Diabetologia ◽  
1980 ◽  
Vol 19 (4) ◽  
pp. 403-404 ◽  
Author(s):  
J. Ditzel ◽  
P. H. Forsham ◽  
M. Lorenzi
Keyword(s):  
Blood Glucose ◽  
Haemoglobin Concentration ◽  
Glycosylated Haemoglobin ◽  
Acute Changes

Platelet Behaviour in Non-Insulin-Dependent Diabetes -Influence of Vascular Complications, Treatment and Metabolic Control

1986 ◽  
Vol 55 (03) ◽  
pp. 361-365 ◽  
Author(s):  
I Peacock ◽  
M Hawkins ◽  
S Heptinstall
Keyword(s):  
Blood Glucose ◽  
Metabolic Control ◽  
Platelet Reactivity ◽  
Platelet Rich Plasma ◽  
Vascular Complications ◽  
Adenosine Diphosphate ◽  
Glycosylated Haemoglobin ◽  
Insulin Dependent Diabetes ◽  
Lipid Levels ◽  
Insulin Dependent

SummaryPlatelet-rich plasma was prepared from 47 patients with noninsulin-dependent diabetes treated with glibenclamide and metformin, and 21 controls. The release of radio-labelled 5-hydroxy-tryptamine in response to aggregating agents (adenosine diphosphate, adrenaline and sodium arachidonate), and the effects on release of a selective thromboxane inhibitor (UK-34787) were investigated. Subsequently, 20 of the diabetic subjects were chosen at random for treatment with insulin; the remainder continued to take tablets. Platelet studies were then repeated, in all patients, after 4 and 6 months.The results showed an association between platelet behaviour and the presence of vascular complications, and were consistent with previous observations of reduced platelet reactivity in patients taking sulphonylureas. There was no correlation of platelet reactivity with blood glucose, glycosylated haemoglobin or lipid levels.

577-P: Choroidal Thickness Is Dependent on BMI and Acute Changes in Blood Glucose

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 577-P
Author(s):  
SVENJA MEYHOEFER ◽  
BRITTA WILMS ◽  
RODRIGO CHAMORRO ◽  
ANNA-JOSEPHIN PAGELS ◽  
HANS-JÜRGEN GREIN ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Choroidal Thickness ◽  
Acute Changes

Attenuation of erythrocyte membrane oxidative stress bySesbania grandiflorain streptozotocin-induced diabetic rats

2015 ◽  
Vol 93 (4) ◽  
pp. 385-395 ◽  
Author(s):  
Chandrabose Sureka ◽  
Thiyagarajan Ramesh ◽  
Vavamohaideen Hazeena Begum
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Blood Glucose ◽  
Erythrocyte Membrane ◽  
Osmotic Fragility ◽  
Diabetic Rats ◽  
Glycosylated Haemoglobin ◽  
Albino Rats ◽  
Enzymatic Antioxidants ◽  
Protective Effects

The aim of the present study was to investigate the protective effects of Sesbania grandiflora flower (SGF) extract on erythrocyte membrane in Streptozotocin (STZ)-induced diabetic rats. Adult male albino rats of Wistar strain, weighing 190–220 g, were made diabetic by an intraperitonial administration of STZ (45 mg/kg). Normal and diabetic rats were treated with SGF, and diabetic rats were also treated with glibenclamide as drug control, for 45 days. In this study plasma insulin and haemoglobin levels were decreased and blood glucose, glycosylated haemoglobin, protein oxidation, lipid peroxidation markers, and osmotic fragility levels were increased in diabetic rats. Moreover, erythrocytes antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxide, glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase activities and non-enzymatic antioxidants such as vitamin C, vitamin E, reduced glutathione (GSH), and oxidized glutathione (GSSG) levels were altered. Similarly, the activities of total ATPases, Na+/K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase were also decreased in the erythrocytes of diabetic rats. Administration of SGF to STZ-induced diabetic rats reduced blood glucose and glycosylated haemoglobin levels with increased levels of insulin and haemoglobin. Moreover, SGF reversed the protein and lipid peroxidation markers, osmotic fragility, membrane-bound ATPases activities, and antioxidant status in STZ-induced diabetic rats. These results suggest that SGF could provide a protective effect on diabetes by decreasing oxidative stress-associated diabetic complications.

Glycosylated haemoglobin: An indicator of long-term blood glucose in domestic sheep and goats

1988 ◽  
Vol 90 (2) ◽  
pp. 229-231 ◽  
Author(s):  
A.I. Alayash ◽  
A.M. El-Hassan ◽  
Ramadan Omer ◽  
J. Bonaventura
Keyword(s):  
Blood Glucose ◽  
Glycosylated Haemoglobin ◽  
Domestic Sheep ◽  
Sheep And Goats

Acute changes in blood glucose and their effects on color vision function in diabetes

1993 ◽  
pp. 165-173 ◽  
Author(s):  
Marilyn E. Schneck ◽  
Anthony J. Adams ◽  
Vicki J. Volbrecht ◽  
John L. Linfoot
Keyword(s):  
Blood Glucose ◽  
Color Vision ◽  
Acute Changes ◽  
Vision Function

Acute changes in blood glucose do not alter blood glutathione synthesis in adolescents with poorly controlled type 1 diabetes mellitus

Metabolism ◽  
2012 ◽  
Vol 61 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Dominique Darmaun ◽  
Susan Welch ◽  
Shiela Smith ◽  
Shawn Sweeten ◽  
Nelly Mauras
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Type 1 Diabetes Mellitus ◽  
Glutathione Synthesis ◽  
Acute Changes

Acute changes in blood glucose affect resistance to ischemic nerve conduction failure

Neurology ◽  
1990 ◽  
Vol 40 (1) ◽  
pp. 107-107 ◽  
Author(s):  
G. J. Parry ◽  
H. Kohzu
Keyword(s):  
Blood Glucose ◽  
Nerve Conduction ◽  
Conduction Failure ◽  
Acute Changes

scholarly journals Time course of reversibility of accelerated fibrinogen disappearance in diabetes mellitus: association with intravascular volume shifts

Blood ◽  
1984 ◽  
Vol 63 (1) ◽  
pp. 22-30
Author(s):  
RL Jones ◽  
L Jovanovic ◽  
S Forman ◽  
CM Peterson
Keyword(s):  
Blood Glucose ◽  
Blood Volume ◽  
Volume Expansion ◽  
Time Course ◽  
Diabetic Patients ◽  
Vascular Volume ◽  
Blood Volume Expansion ◽  
Artificial Beta Cell ◽  
Acute Changes ◽  
Osmotic Effects

Accelerated fibrinogen disappearance in diabetic patients is reversible with normalization of blood glucose. To define the time course of this reversal, we measured 125I-fibrinogen disappearance in 19 diabetic patients experiencing acute changes in blood glucose, as monitored and controlled by a microprocessor-controlled closed loop insulin infusion system (artificial beta cell). The data were corrected for blood volume dilutional changes and fit to a model describing two sequential exponential functions and a single exponential function. The sequential model provided the best fit for all but one patient. This indicates that there were two distinct rates of fibrinogen disappearance and suggests that the time course of reversal of accelerated fibrinogen disappearance in diabetic patients is very rapid, if not immediate. Rapid fibrinogen turnover during hyperglycemia was temporally associated with vascular volume changes, reflected as dilutional changes of 51Cr-RBC concentrations. These findings were also associated with an increase in pulse pressure during hyperglycemia, suggesting blood volume expansion due to an osmotic mechanism. The results of this study suggest a picture of vascular volume expansion and contraction, perhaps secondary to the osmotic effects of hyperglycemia. Accelerated fibrinogen turnover associated with these events may be related to increased vascular permeability and/or increased fibrin formation. These events, in concert, may contribute to the initiation and/or propagation of diabetic vascular sequelae.

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