Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop

There is significant interest in the development of new drugs to treat vascular dementia. However, before US approval of new drugs for this entity is possible, certain issues with regulatory implications need to be addressed. Is vascular dementia a distinct clinical syndrome with valid diagnostic criteria? Can this entity be distinguished from Alzheimer's disease (AD) and other causes of dementia? What design features are important for clinical trials in this disorder? The US Food and Drug Administration (FDA) convened a special meeting of the Peripheral and Central Nervous System Advisory Committee in an attempt to answer these questions. The conclusions from this meeting indicate that vascular dementia (VaD) is a pathologically heterogeneous disorder but appears to be reasonably distinguishable from AD dementia. The NINDS-AIREN diagnostic criteria are suitable as entry criteria for vascular dementia trials. Trials should be similar in duration to AD dementia trials and should employ a dual outcome strategy (cognitive + global/functional measures). For drugs that are believed to have a disease-modifying effect, clinical trials should study specific vascular dementia subtypes and would need to employ substantially different designs from those used currently. The term “vascular dementia” may not be entirely appropriate to describe this population.

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Clinical-psychopathological structure of hallucinatory-paranoid disorders during vascular dementia of moderate degrees of severity

Ukrains'kyi Visnyk Psykhonevrolohii ◽

10.36927/2079-0325-v27-is2-2019-14 ◽

2019 ◽

Vol 27 (2 (99)) ◽

pp. 63-67

Author(s):

Kostiantyn Shevchenko-Bitensky

Keyword(s):

Vascular Dementia ◽

Diagnostic Criteria ◽

Main Group ◽

Control Group ◽

Stage Of Development ◽

Keywords Dementia ◽

Paranoid Symptoms ◽

Degrees Of Severity

41 patients with vascular dementia in the medium stage of development with mixed cortical and subcortical dysfunction with hallucinatory-paranoid symptoms (main group) were examined. The control group consisted of 34 patients with vascular dementia in the medium stage of development without hallucinatoryparanoid disorders. The patterns of clinical and psychopathological manifestations of hallucinatory-paranoid disorders in patients with vascular dementia in the medium stage of development were established, which can be considered as diagnostic criteria for assessing the clinical and psychopathological structure of hallucinatory-paranoid disorders in this pathology. Keywords: dementia, hallucinatoryparanoid symptoms, clinical and psychopathological manifestations

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The importance of harmonising diagnostic criteria sets for pathological grief

The British Journal of Psychiatry ◽

10.1192/bjp.2019.240 ◽

2019 ◽

pp. 1-4 ◽

Cited By ~ 15

Author(s):

Lonneke I. M. Lenferink ◽

Paul A. Boelen ◽

Geert E. Smid ◽

Muirne C. S. Paap

Keyword(s):

Diagnostic Criteria ◽

Predictive Validity ◽

Prevalence Rates ◽

Pathological Grief ◽

Research Studies

Summary Five diagnostic criteria sets for pathological grief are currently used in research. Studies evaluating their performance indicate that it is not justified to generalise findings regarding prevalence rates and predictive validity across studies using different diagnostic criteria of pathological grief. We provide recommendations to move the bereavement field forward.

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Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-313356 ◽

2019 ◽

Vol 103 (10) ◽

pp. 1418-1422 ◽

Cited By ~ 30

Author(s):

Manabu Mochizuki ◽

Justine R Smith ◽

Hiroshi Takase ◽

Toshikatsu Kaburaki ◽

Nisha R Acharya ◽

...

Keyword(s):

Differential Diagnosis ◽

Diagnostic Criteria ◽

International Workshop ◽

Clinical Signs ◽

International Meeting ◽

Granulomatous Uveitis ◽

Ocular Sarcoidosis

AimsInternational criteria for the diagnosis of ocular sarcoidosis (OS) was established by the first International Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations of the criteria. To overcome the limitations, revised IWOS criteria was established in an international meeting. This manuscript was aimed at reporting the revised IWOS criteria.MethodsA consensus workshop was carried out to discuss and revise the IWOS criteria. The workshop was held on 27 April 2017, in Nusa Dua, Bali, Indonesia. Prior to the workshop, a questionnaire proposing revised criteria and consisting of one item for differential diagnosis, seven items for ocular clinical signs, 10 items for systemic investigations and three categories of diagnostic criteria was circulated to 30 uveitis specialists. Questionnaire items with over 75% support were taken as consensus agreement; items with below 50% support were taken as consensus disagreement and items with 50%–75% support were discussed at the workshop. Of the latter items, those supported by two-thirds majority in the workshop were taken as consensus agreement.ResultsThe survey and subsequent workshop reached consensus agreements of the revised criteria for the diagnosis of OS as follows: (1) other causes of granulomatous uveitis must be ruled out; (2) seven intraocular clinical signs suggestive of OS; (3) eight results of systemic investigations in suspected OS and (4) three categories of diagnostic criteria depending on biopsy results and combination of intraocular signs and results of systemic investigations.ConclusionsRevised IWOS criteria were proposed by a consensus workshop.

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Vascular dementia: Diagnostic criteria and supplementary exams: Recommendations of the Scientific Department of Cognitive Neurology and Aging of the Brazilian Academy of Neurology. Part I.

Dementia & Neuropsychologia ◽

10.1590/s1980-57642011dn05040003 ◽

2011 ◽

Vol 5 (4) ◽

pp. 251-263 ◽

Cited By ~ 6

Author(s):

Eliasz Engelhardt ◽

Carla Tocquer ◽

Charles André ◽

Denise Madeira Moreira ◽

Ivan Hideyo Okamoto ◽

...

Keyword(s):

Vascular Dementia ◽

Diagnostic Criteria ◽

Diagnostic System ◽

Vascular Cognitive Impairment ◽

Evidence Based ◽

Basic Principles ◽

Pertinent Information ◽

Meta Analyses ◽

Prevalent Form ◽

Cognitive Impairment No Dementia

Abstract Vascular dementia (VaD) is the most prevalent form of secondary dementia and the second most common of all dementias. The present paper aims to define guidelines on the basic principles for treating patients with suspected VaD (and vascular cognitive impairment - no dementia) using an evidence-based, systematized approach. The knowledge used to define these guidelines was retrieved from searches of several databases (Medline, Scielo, Lilacs) containing scientific articles, systematic reviews, meta-analyses, largely published within the last 15 years or earlier when pertinent. Information retrieved and selected for relevance was used to analyze diagnostic criteria and to propose a diagnostic system encompassing diagnostic criteria, anamnesis, as well as supplementary and clinical exams (neuroimaging and laboratory). Wherever possible, instruments were selected that had versions previously adapted and validated for use in Brazil that take into account both schooling and age. This task led to proposed protocols for supplementary exams based on degree of priority, for application in clinical practice and research settings.

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