Risk factors and outcome of patients with carotid artery stenosis presenting with lacunar stroke

Neurology ◽  
2000 ◽  
Vol 54 (3) ◽  
pp. 660-660 ◽  
Author(s):  
D. Inzitari ◽  
M. Eliasziw ◽  
B. L. Sharpe ◽  
A. J. Fox ◽  
H. J. M. Barnett
2013 ◽  
Vol 28 (2) ◽  
pp. 88-95
Author(s):  
Dewan Md Elyas ◽  
Aminur Rahman ◽  
Quazi Deen Mohammad ◽  
Badrul Alam Mondol ◽  
Sakhawat Hossain ◽  
...  

Background: Stroke is a leading cause of mortality and morbidity in both developed as well as developing countries The risk factors in lacunar stroke differ in comparison to nonlacunar strokes. In this study risk factors of lacunar stroke in comparison to non-lacunar were evaluated. Objectives: The aim of the study was to compare the risk factors among lacunar stroke and non-lacunar stroke. Methodology: This comparative study conducted in the department of Medicine and Neurology, Dhaka Medical College Hospital, Dhaka from September 2010 to August 2011. MRI of brain was done in 151 patients above 18 years of age with ischemic stroke and Lacunar stroke was found in 31 patients and non-lacunar stroke was detected in 120 patients. Based on the inclusion and exclusion criteria from them 30 patients with lacunar stroke were selected as Group-A patients and equal number of non-lacunar stroke same ages as group B were compared of. The risk factors of stroke were defined as hypertension, diabetes mellitus, hypercholesterolemia, smoking, history of transient ischemic attack, myocardial infarction, atrial fibrillation and carotid artery stenosis. Results: Out of 151 patients with ischemic stroke non-lacunar stroke was predominant, which was 79.47% and lacunar stroke was 20.52%. The mean age was found 60.9±10.2 years in Group A and 56.2±11.8 years in Group B, which was almost similar between two groups (p>0.05). Male were predominant, which was 63.33% and 76.67% in lacunar and non-lacunar stroke respectively. Male and female ratio was 2.3:1. Regarding the risk factors hypertension was observed most common risk factor among the patients having lacunar and non-lacunar strokes. Hypertension and diabetes mellitus were common in lacunar stroke and myocardial infarction, carotid artery stenosis and hypercholesterolemia were common in non-lacunar stroke which were statistically significant (p<0.05) between the both groups. However, the percentage of smoking, previous TIA and atrial fibrillation were not significantly (p>0.05) different between lacunar and non-lacunar stroke. Conclusion: Hypertension and diabetes mellitus were common in lacunar stroke, and myocardial infarction, whereas carotid artery stenosis and hypercholesterolemia were common in non-lacunar stroke and the both groups were statistically significant (p<0.05) . So modification of risk factors may reduce the incidence of ischemic stroke. DOI: http://dx.doi.org/10.3329/bjn.v28i2.17176 Bangladesh Journal of Neuroscience 2012; Vol. 28 (2): 88-95


2017 ◽  
Vol 65 (2) ◽  
pp. 279 ◽  
Author(s):  
Subhash Kaul ◽  
Suvarna Alladi ◽  
KRukmini Mridula ◽  
V C SSrinivasarao Bandaru ◽  
Matapathi Umamashesh ◽  
...  

2018 ◽  
Vol 93 (3) ◽  
pp. E134-E139 ◽  
Author(s):  
Najibullah Habib ◽  
Bakhtawar K. Mahmoodi ◽  
Maarten J. Suttorp ◽  
Johannes C. Kelder ◽  
Selma C. Tromp ◽  
...  

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Worapot Rojsanga ◽  
Kittisak Sawanyawisuth ◽  
Verajit Chotmongkol ◽  
Somsak Tiamkao ◽  
Kannikar Kongbonkiat ◽  
...  

Large cerebral infarctions have high morbidity and mortality. Patients with large cerebral infarctions may have recurrent ischemia as high as 8.1% within 7 days; highest among other types of strokes. Data regarding risk factors for large cerebral infarction in Asian populations are still scant. All adult (age ≥15 years old) patients with the diagnosis of thrombotic ischemic stroke who were treated at Srinagarind Hospital, Khon Kaen University, Thailand from January 2012 to December 2013 were studied. Large cerebral infarctions are defined by clinical criteria of having cerebral cortical impairment, brain stem or cerebellar dysfunction with infarction sizes of more than 1.5 cm. The association of various stroke risk factors and large infarction strokes were calculated using multiple logistic regression analysis. There were 276 thrombotic stroke patients who met the study criteria; classified as large cerebral infarctions in 59 patients (21.38%) and small cerebral infarctions in 217 patients (78.62%). Baseline characteristics and risk factors for stroke were comparable between both groups. The large cerebral infarction group had a significantly larger proportions of right internal carotid artery stenosis, plaques on the left side, left internal carotid artery stenosis, and internal carotid artery stenosis at any side than the small cerebral infarction group. Among various stroke risk factors, only internal carotid artery stenosis at any side was the only significant factor associated with large cerebral infarction with an adjusted odds ratio of 11.14 (95% CI: 3.46, 35.82). In conclusion, significant internal carotid artery stenosis is associated with large cerebral infarction.


Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Vishal B Jani ◽  
Adil Malik ◽  
Asif Khan ◽  
Sayed Hussain ◽  
Malathi Rao ◽  
...  

Objective: Elevated resting heart rate has been independently associated with cardiovascular and all-cause mortality, but association of it with cerebrovascular disease has been unexplored. The pathophysiological mechanisms by which this increased risk occurs are unclear. We hypothesized that elevated resting heart rate will be associated with increased development of atherosclerosis, as assessed by the incidence and progression of carotid artery stenosis and plaque morphology. METHODS: The Multi-Ethnic Study of Atherosclerosis is a prospective cohort study of participants free of clinical cardiovascular and cerebrovascular disease at entry. Healthy Subjects with baseline carotid stenosis by carotid duplex were stratified into five categories according to resting heart rate of: 36-55, 56 -60, 61-65, 66-71, >71bpm). Carotid stenosis incidence was assessed by relative risk regression after adjusting for comorbidities. Heart rate 36-55 was kept as a reference tier system. RESULTS: Of 6667 healthy individuals with an average age of 62, 3462 were men and 3511 were females. With successive increase in heart rate there was increased in associated comorbidities like hypertension, (40.3%,42%,43.2% with respective p value of 0.0001,0.0003,0.02 in tier 2,3 & 4), DM (9.7%,13.6%,20.2% with p=0.01,<0.0001 and 0.0001 respectively in tier 3, 4 & 5). Similar trend was noticed in baseline labs with increment in heart rate Total cholesterol 36.4%,36.1%,39.4% with p=0.0004,0.001,<0.0001 respectively in tier 3,4,5), CRP (4.5%,5.6%,6%,8.4% with p= ,0.0001, in each tier 2, 3,4,5). However, there did not seem to be any correlation between carotid stenosis and resting heart rate. CONCLUSION: Elevated resting heart rate, a well-described predictor of cardiovascular mortality with unclear mechanism, is associated with cerebrovascular risk factors, but not with the occurrence of asymptomatic extracranial carotid artery stenosis.


2021 ◽  
pp. 69-72
Author(s):  
Sudipta Basu ◽  
Sukanya Banerjee ◽  
Prasun Das ◽  
Swadha Priya Basu

Background: Ischemic heart disease (IHD) is a major cause of mortality and morbidity all over the world. The burden of IHD in India can be explained by the alarming rise in the prevalence of coronary risk factors like diabetes, hypertension, atherogenic dyslipidemia, smoking, central obesity and physical inactivity. For more than a decade various sonographic techniques have been used for the assessment arterial of carotid disease. Aim: to establish the role of Gray Scale USG and carotid artery Doppler study as a leading investigation in general population presenting with Stable Ischemic Heart Disease and to evaluate the frequency and degree of carotid artery stenosis in these patients & also assess the morphology of atherosclerotic plaque and IMT;to nd association between carotid artery stenosis and risk factors such as hypertension, diabetes, ,deranged lipid prole ,smoking and age. Materials and methods: 50 patients were included in a prospective cross sectional study.Patients below 12 years of age were not included.Forty two were male(84%) and rest were female(16%);all were admitted in cardiology ward and OPD already having undergone coronary angiography.They were evaluated by gray scale as well as doppler ultrasound of both carotid arteries and the results were corroborated with angiography ndings. For statistical analysis data were entered into a Microsoft excel spreadsheet and then analyzed by SPSS (version 24.0; SPSS Inc., Chicago, IL, USA) and Graph Pad Prism version 5. Correlation was calculated by Pearson correlation analysis Results: In our study out of 50 patients with IHD 33 patients had atheromatous plaque. Abnormal carotid intima – media thickness (IMT) was found in 40 (80%) of the study population. Multiple risk factors were present in our study group where most common risk factor was hypertension (78%) ,smoking (74%) and followed by Dyslipidaemia (72%) and Diabetes (70%). Other risk factors (66%) were present in signicant number of cases. From our study we can conclude that raised PSV across the carotid lesion will predict severe nature of coronary artery disease. Conclusions: It has been found that multiple risk factors are associated with increased risk of ischemic heart disease. Further studies can be done in persons with multiple risk factors to assess Carotid Intima media thickness as a screening tool to reduce risk of ischemic heartdisease. .Highresolution B-mode real-time sonography with Continuous-wave Doppler and single-gate pulsed wave sono Doppler graphy easily evaluates the frequency and degree of carotid artery stenosis in these patients and also assess the morphology of atherosclerotic plaque and intima-medial thickness which are clearly related to pathogenesis and aid in planning of management.


1999 ◽  
Vol 33 (6) ◽  
pp. 697-704
Author(s):  
Christos D. Liapis ◽  
John D. Kakisis ◽  
Vassilios G. Papavassiliou ◽  
Konstantinos M. Koumakis ◽  
John G. Gogas

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