Prolonged Sevoflurane Inhalation Was Not Nephrotoxic in Two Patients with Refractory Status Asthmaticus

AbstractRefractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite aggressive organ support with invasive ventilation and extracorporeal membrane oxygenation. Omalizumab, a humanized recombinant monoclonal anti-IgE antibody, is an approved add-on biological treatment for severe asthma. However, it is not indicated in an acute setting. Here, we report the case of a young patient with status asthmaticus fully dependent on extracorporeal membrane oxygenation refractory to any therapy for six days, who was successfully treated with omalizumab.

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Combined bronchoscopy and mucolytic therapy for patients with severe refractory status asthmaticus on mechanical ventilation: A case report and review of the literature

Critical Care Medicine ◽

10.1097/00003246-199422110-00027 ◽

1994 ◽

Vol 22 (11) ◽

pp. 1880-1883 ◽

Cited By ~ 1

Author(s):

Craig A. Henke ◽

Marshall Hertz ◽

Paul Gustafson

Keyword(s):

Mechanical Ventilation ◽

Case Report ◽

Status Asthmaticus ◽

Review Of The Literature ◽

Refractory Status

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Pumpless Extracorporeal Lung Assist for the Treatment of Severe, Refractory Status Asthmaticus

Journal of Asthma ◽

10.3109/02770903.2010.528500 ◽

2010 ◽

Vol 48 (1) ◽

pp. 111-113 ◽

Cited By ~ 19

Author(s):

Christian Jung ◽

Alexander Lauten ◽

Ruediger Pfeifer ◽

Philipp Bahrmann ◽

Hans R Figulla ◽

...

Keyword(s):

Status Asthmaticus ◽

Extracorporeal Lung Assist ◽

Refractory Status ◽

Pumpless Extracorporeal Lung Assist

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Influenza A triggered status asthmaticus requiring emergency ECMO

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2010.286 ◽

2016 ◽

Vol 73 (4) ◽

Author(s):

F. Guarracino ◽

M. Stefani ◽

P. Maremmani ◽

M. Corini ◽

S. Pini ◽

...

Keyword(s):

Mechanical Ventilation ◽

Case Report ◽

Respiratory Failure ◽

Influenza A Virus ◽

Influenza A ◽

Status Asthmaticus ◽

Severe Pneumonia ◽

Refractory Status ◽

Threatening Condition ◽

Life Threatening

We describe a case of acute respiratory failure due to severe pneumonia triggered by the influenza A virus, rapidly evolving into a refractory status asthmaticus requiring emergent ECMO assistance, in order to facilitate the clinical management of patients suffering from this rare but life-threatening condition. This case report demonstrates that infection with influenza A virus can present with severe pneumonia and status asthmaticus refractory to medical and ventilatory treatment. When medical treatment and mechanical ventilation fail, extracorporeal membrane oxygenation therapy should not be delayed as it will avoid injury resulting from inadequate mechanical ventilation and lung hyperinflation.

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