scholarly journals Successful treatment of refractory status asthmaticus with omalizumab: a case report

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Jan Benes ◽  
Roman Skulec ◽  
Dalibor Jilek ◽  
Ondrej Fibigr ◽  
Vladimir Cerny
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Biological Treatment ◽  
Status Asthmaticus ◽  
Organ Support ◽  
Hospital Death ◽  
Line Treatment ◽  
Invasive Ventilation ◽  
Acute Setting ◽  
Membrane Oxygenation ◽  
Refractory Status

AbstractRefractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite aggressive organ support with invasive ventilation and extracorporeal membrane oxygenation. Omalizumab, a humanized recombinant monoclonal anti-IgE antibody, is an approved add-on biological treatment for severe asthma. However, it is not indicated in an acute setting. Here, we report the case of a young patient with status asthmaticus fully dependent on extracorporeal membrane oxygenation refractory to any therapy for six days, who was successfully treated with omalizumab.

scholarly journals Utilization of extracorporeal membrane oxygenation for refractory status asthmaticus during pregnancy: A case report

2020 ◽  
Vol 8 (2) ◽  
pp. 92
Author(s):  
Hye Sung Ock ◽  
Lae Hyung Kang ◽  
Hye Ju Yeo ◽  
Seong Hoon Yoon ◽  
Woo Hyun Cho ◽  
...  
Keyword(s):  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Status Asthmaticus ◽  
Membrane Oxygenation ◽  
Refractory Status

scholarly journals Spontaneous breathing in patients with severe acute respiratory distress syndrome receiving prolonged extracorporeal membrane oxygenation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jingen Xia ◽  
Sichao Gu ◽  
Min Li ◽  
Donglin Liu ◽  
Xu Huang ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Extracorporeal Membrane Oxygenation ◽  
Hospital Mortality ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Ecmo Support ◽  
Invasive Ventilation ◽  
Membrane Oxygenation ◽  
Native Lung

Abstract Background The use of extracorporeal membrane oxygenation (ECMO) in awake, spontaneously breathing and non-intubated patients (awake ECMO) may be a novel therapeutic strategy for severe acute respiratory distress syndrome (ARDS) patients. The purpose of this study is to assess the feasibility and safety of awake ECMO in severe ARDS patients receiving prolonged ECMO (> 14 days). Methods We describe our experience with 12 consecutive severe ARDS patients (age, 39.1 ± 16.4 years) supported with awake ECMO to wait for native lung recovery during prolonged ECMO treatment from July 2013 to January 2018. Outcomes are reported including the hospital mortality, ECMO-related complications and physiological data on weaning from invasive ventilation. Results The patients received median 26.0 (15.5, 64.8) days of total ECMO duration in the cohort. The longest ECMO support duration was 121 days. Awake ECMO and extubation was implemented after median 10.2(5.0, 42.9) days of ECMO. Awake ECMO was not associated with increased morbidity. The total invasive ventilation duration, lengths of stay in the ICU and hospital in the cohort were 14.0(12.0, 37.3) days, 33.0(22.3, 56.5) days and 46.5(27.3, 84.8) days, respectively. The hospital mortality rate was 33.3% (4/12) in the cohort. Survivors had more stable respiratory rate and heart rate after extubation when compared to the non-survivors. Conclusions With carefully selected patients, awake ECMO is a feasible and safe strategy for severe pulmonary ARDS patients receiving prolonged ECMO support to wait for native lung recovery.

scholarly journals Usefulness of extracorporeal membrane oxygenation in status asthmaticus with severe tracheal stenosis

2020 ◽  
Vol 33 (3) ◽  
pp. 404-406
Author(s):  
Chibuzo Odigwe ◽  
Jake Krieg ◽  
William Owens ◽  
Cathy Lopez ◽  
Rohan Ranjit Arya
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Tracheal Stenosis ◽  
Status Asthmaticus ◽  
Membrane Oxygenation
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