Combined Catechol-O-Methyltransferase and μ-Opioid Receptor Gene Polymorphisms Affect Morphine Postoperative Analgesia and Central Side Effects

2011 ◽  
Vol 112 (2) ◽  
pp. 448-453 ◽  
Author(s):  
Yuri Kolesnikov ◽  
Boris Gabovits ◽  
Ariel Levin ◽  
Edward Voiko ◽  
Andres Veske
Keyword(s):  
Side Effects ◽  
Opioid Receptor ◽  
Postoperative Analgesia ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Μ Opioid Receptor ◽  
Receptor Gene Polymorphisms

Effect of μ-Opioid Receptor Gene Polymorphisms on Heroin-Induced Subjective Responses in a Chinese Population

2007 ◽  
Vol 61 (11) ◽  
pp. 1244-1251 ◽  
Author(s):  
Dandan Zhang ◽  
Chunhong Shao ◽  
Minhua Shao ◽  
Pengrong Yan ◽  
Yi Wang ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Receptor Gene ◽  
Subjective Responses ◽  
Μ Opioid Receptor ◽  
Receptor Gene Polymorphisms

Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse

1997 ◽  
Vol 2 (3) ◽  
pp. 303-308 ◽  
Author(s):  
WADE H. BERRETTINI ◽  
MARGRET R. HOEHE ◽  
THOMAS N. FERRARO ◽  
PETER A. DEMARIA ◽  
EDWARD GOTTHEIL
Keyword(s):  
Substance Abuse ◽  
Opioid Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Mu Opioid Receptor ◽  
Mu Opioid ◽  
Receptor Gene Polymorphisms

Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations

Neuroreport ◽  
2003 ◽  
Vol 14 (4) ◽  
pp. 569-572 ◽  
Author(s):  
Ene-Choo Tan ◽  
Chay-Hoon Tan ◽  
Umavathy Karupathivan ◽  
Eric P. H. Yap
Keyword(s):  
Opioid Receptor ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Mu Opioid Receptor ◽  
Heroin Dependence ◽  
Mu Opioid ◽  
Asian Populations ◽  
Receptor Gene Polymorphisms

Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics

2020 ◽  
Vol 20 (31) ◽  
pp. 2866-2877
Author(s):  
Hirokazu Mizoguchi ◽  
Hideaki Fujii
Keyword(s):  
Side Effects ◽  
Opioid Receptor ◽  
Opioid Receptors ◽  
Analgesic Effect ◽  
Splice Variants ◽  
Receptor Gene ◽  
Molecular Target ◽  
Μ Opioid Receptor ◽  
Dependence Liability ◽  
Μ Opioid Receptors

Since a μ-opioid receptor gene containing multiple exons has been identified, the variety of splice variants for μ-opioid receptors have been reported in various species. Amidino-TAPA and IBNtxA have been discovered as new analgesics with different pharmacological profiles from morphine. These new analgesics show a very potent analgesic effect but do not have dependence liability. Interestingly, these analgesics show the selectivity to the morphine-insensitive μ-opioid receptor splice variants. The splice variants, sensitive to these new analgesics but insensitive to morphine, may be a better molecular target to develop the analgesics without side effects.

Sign in / Sign up

Export Citation Format

Share Document