Exploring μ-Opioid Receptor Splice Variants as a Specific Molecular Target for New Analgesics
2020 ◽
Vol 20
(31)
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pp. 2866-2877
Keyword(s):
Since a μ-opioid receptor gene containing multiple exons has been identified, the variety of splice variants for μ-opioid receptors have been reported in various species. Amidino-TAPA and IBNtxA have been discovered as new analgesics with different pharmacological profiles from morphine. These new analgesics show a very potent analgesic effect but do not have dependence liability. Interestingly, these analgesics show the selectivity to the morphine-insensitive μ-opioid receptor splice variants. The splice variants, sensitive to these new analgesics but insensitive to morphine, may be a better molecular target to develop the analgesics without side effects.
2000 ◽
Vol 78
(1-2)
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pp. 204-206
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Keyword(s):
Keyword(s):
2012 ◽
Vol 107
(3)
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pp. 1022-1031
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2004 ◽
Vol 123
(1)
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pp. 111-121
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2011 ◽
Vol 112
(2)
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pp. 448-453
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2004 ◽
Vol 286
(4)
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pp. R634-R641
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2006 ◽
Vol 95
(4)
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pp. 2032-2041
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2013 ◽
Vol 288
(29)
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pp. 21211-21227
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Keyword(s):
2001 ◽
Vol 62
(4)
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pp. 447-455
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Keyword(s):