Optic Nerve Glioma and Optic Neuritis Mimicking One Another: Case Report

Neurosurgery ◽  
2005 ◽  
Vol 57 (1) ◽  
pp. E190-E190 ◽  
Author(s):  
Luis M. Tumialán ◽  
Sanjay S. Dhall ◽  
Valérie Biousse ◽  
Nancy J. Newman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Optic Neuritis ◽  
Visual Loss ◽  
Radiographic Finding ◽  
Acute Onset ◽  
Resonance Imaging ◽  
Optic Nerve Glioma ◽  
The Right

Abstract OBJECTIVE AND IMPORTANCE: The clinical and radiographic presentations of optic nerve gliomas and optic neuritis are for the most part distinct and their diagnoses straightforward. We present two cases illustrating the occasional difficulty one can encounter in distinguishing neoplastic from inflammatory optic neuropathies. CLINICAL PRESENTATION: Patient 1 is a 17-year-old girl who presented with acute onset of pain and rapidly progressive visual loss in the right eye. Patient 2 is a 38-year-old man who presented with painless progressive visual loss in the left eye. INTERVENTION: Patient 1 was initially diagnosed with idiopathic retrobulbar optic neuritis. Interval increase of the optic nerve on magnetic resonance imaging prompted a biopsy of the optic nerve, which revealed a pilocytic astrocytoma. Patient 2 was found to have left optic nerve enhancement most consistent with an optic nerve glioma. Before a biopsy, the patient spontaneously improved without treatment, indicating an inflammatory process. CONCLUSION: Differentiating between optic nerve neoplasm and inflammation may be difficult. On occasion, the classic clinical finding of pain with eye movement and the radiographic finding of enlargement and enhancement of the optic nerve may be misleading. Open biopsy of the optic nerve is indicated only after a completely negative metabolic, infectious, and inflammatory workup; interval increase of the optic nerve on magnetic resonance imaging; and failure of the patient to recover vision.

scholarly journals Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis

2021 ◽  
Vol 15 ◽  
Author(s):  
Ke Song ◽  
Yong Wang ◽  
Mei-Xia Ren ◽  
Jiao Li ◽  
Ting Su ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Functional Magnetic Resonance Imaging ◽  
Optic Neuritis ◽  
Resting State ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Functional Connectivity Density ◽  
The Right

Background: Using resting-state functional connectivity (rsFC), we investigated alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with optic neuritis (ON).Methods: We enrolled 28 patients with ON (18 males, 10 females) and 24 healthy controls (HCs; 16 males, 8 females). All subjects underwent functional magnetic resonance imaging (fMRI) in a quiet state to determine the values of rsFC, long-range FCD (longFCD), and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were generated to distinguish patients from HCs.Results: The ON group exhibited obviously lower longFCD values in the left inferior frontal gyrus triangle, the right precuneus and the right anterior cingulate, and paracingulate gyri/median cingulate and paracingulate gyri. The left median cingulate and paracingulate gyri and supplementary motor area (SMA) were also significantly lower. Obviously reduced IFCD values were observed in the left middle temporal gyrus/angular gyrus/SMA and right cuneus/SMA compared with HCs.Conclusion: Abnormal neural activities were found in specific brain regions in patients with ON. Specifically, they showed significant changes in rsFC, longFCD, and IFCD values. These may be useful to identify the specific mechanism of change in brain function in ON.

Optic nerve ganglioglioma

1993 ◽  
Vol 78 (6) ◽  
pp. 979-982 ◽  
Author(s):  
William Y. Lu ◽  
Marc Goldman ◽  
Byron Young ◽  
Daron G. Davis
Keyword(s):  
Magnetic Resonance Imaging ◽  
Nervous System ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Visual Field ◽  
Resonance Imaging ◽  
Optic Nerve Glioma ◽  
Content Type ◽  
Visual Field Deficit ◽  
Fine Print

✓ Gangliogliomas of the optic nerve are extremely rare. The case is reported of a 38-year-old man who presented with a visual field deficit and was discovered to have an optic nerve ganglioglioma. The possible embryological origins of this neoplasm, its histological and immunohistochemical features, and its appearance on magnetic resonance imaging are examined. The prognoses of optic nerve glioma and of gangliogliomas occurring elsewhere in the nervous system are compared.

DETECTION OF OPTIC NERVE LESIONS IN OPTIC NEURITIS WITH MAGNETIC RESONANCE IMAGING

The Lancet ◽  
1986 ◽  
Vol 327 (8496) ◽  
pp. 1490-1491 ◽  
Author(s):  
D.H Miller ◽  
G Johnson ◽  
W.I Mcdonald ◽  
D Macmanus ◽  
E.P.G.H Duboulay ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Optic Neuritis ◽  
Resonance Imaging ◽  
Nerve Lesions

Magnetic resonance imaging of the optic nerve in optic neuritis

Neurology ◽  
1988 ◽  
Vol 38 (2) ◽  
pp. 175-175 ◽  
Author(s):  
D. H. Miller ◽  
M. R. Newton ◽  
J. C. van der Poel ◽  
E. P. G. H. du Boulay ◽  
A. M. Halliday ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Optic Neuritis ◽  
Resonance Imaging

Chemical shift selective magnetic resonance imaging of the optic nerve in patients with acute optic neuritis

1988 ◽  
Vol 29 (6) ◽  
pp. 629-632 ◽  
Author(s):  
H. B. W. Larsson ◽  
C. Thomsen ◽  
J. Frederiksen ◽  
O. Henriksen ◽  
J. Olesen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Chemical Shift ◽  
Optic Neuritis ◽  
Resonance Imaging ◽  
Acute Optic Neuritis

scholarly journals Low-Field Magnetic Resonance Imaging Findings in 18 Dogs With Presumed Optic Neuritis

2021 ◽  
Vol 7 ◽  
Author(s):  
Laura Muñiz Moris ◽  
Giunio Bruto Cherubini ◽  
Abby Caine
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Optic Neuritis ◽  
Optic Chiasm ◽  
Optic Nerve Sheath ◽  
Resonance Imaging ◽  
Mri Findings ◽  
Low Field ◽  
Nerve Sheath

Canine optic neuritis has been attributed to a focal or disseminated form of granulomatous meningoencephalitis (GME) amongst other etiologies. Magnetic resonance imaging (MRI) has been proven to help differentiate the structures within the optic nerve sheath and therefore could aid the diagnosis of optic neuritis in dogs. The objectives of this study were to describe and compare the MRI abnormalities affecting the optic nerve sheath complex and optic chiasm in dogs with clinically suspected optic neuritis as a component of meningoencephalitis of unknown etiology (MUE) or as an isolated form (I-ON). Retrospective evaluation of patient details, clinical signs, cerebrospinal fluid (CSF) analysis, and MRI findings of dogs with clinically suspected optic neuritis between January 2011 and May 2018 was performed. Eighteen dogs met the inclusion criteria. MRI findings included contrast enhancement of both optic nerves (11/18) and optic chiasm (6/18), changes within the CSF volume surrounding the optic nerve (10/18), changes to the optic disc (10/18), changes of size or signal affecting the optic chiasm (10/18), changes in the Short TI inversion recovery (STIR) signal of the optic nerve (7/15), retrobulbar changes (3/18), and concurrent brain lesions (13/18). A variety of subtle MRI features may indicate optic nerve involvement and low-field MRI is a sensitive method to detect changes within the optic nerve sheath complex in dogs with optic neuritis as an isolated form (I-ON) or as an extension of MUE.

scholarly journals Optociliary Shunt Vessel: An Ancillary Ophthalmic Sign Harbingering Optic Nerve Sheath Meningioma

2019 ◽  
Vol 16 (3) ◽  
pp. 62-64
Author(s):  
Bikram Bahadur Thapa ◽  
Sweta Singh ◽  
Rakshya Basnet ◽  
Saurav Piya
Keyword(s):  
Magnetic Resonance Imaging ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Visual Field ◽  
Optic Nerve Sheath ◽  
Relative Afferent Pupillary Defect ◽  
Resonance Imaging ◽  
Nerve Sheath ◽  
Optic Nerve Sheath Meningioma ◽  
The Right

A 61-year-old male presented with gradual loss of vision in his right eye for one year at neuro ophthalmology clinic. On clinical examination, his visual acuity was perception of light and intraocular pressure was 12 mm of Hg in right eye. Also, there was relative afferent pupillary defect in the right eye. Fund us examination showed per papillary atrophy, temporal pallor in optic disc with dilated and tortuous optociliary shunt vessels in right eye. Presence of optociliary shunt, visual loss, relative afferent pupillary defect and optic atrophyopt us for further evaluation by visual field and magnetic resonance imaging. Visual field showed unilateral blindness suggesting lesion of optic nerve. Magnetic resonance imaging brain revealed optic nerve sheath meningioma.

Inflammatory optic neuropathy in granulomatosis with polyangiitis can mimick isolated idiopathic optic neuritis

2019 ◽  
pp. 112067211988900
Author(s):  
Manon Clément ◽  
Antoine Néel ◽  
Frédérique Toulgoat ◽  
Michel Weber ◽  
Pascal Godmer ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Visual Acuity ◽  
Optic Nerve ◽  
Magnetic Resonance ◽  
Literature Review ◽  
Optic Neuropathy ◽  
Visual Loss ◽  
Granulomatosis With Polyangiitis ◽  
Orbital Apex ◽  
Resonance Imaging

Objective: We describe a clinico-radiological presentation of inflammatory optic neuropathy that mimicked optic neuritis. Methods: Retrospective single-center case series and literature review of optic neuropathy without orbital pseudotumor. Results: Five local patients fulfilled the inclusion criteria. Clinical presentation revealed rapidly progressive severe unilateral visual loss, retrobulbar pain (n = 4), and paralytic strabismus (simultaneous = 2, protracted = 2) without proptosis. Optic nerve abnormality was not appreciated on initial scan review. Patients did not have any general activity of the granulomatosis with polyangiitis. Upon follow-up magnetic resonance imaging and initial imaging review, all patients revealed orbital apex anomalies. Visual acuity improved in three patients who received high-dose intravenous glucocorticosteroids immediately. Relapse was frequent and visual outcome was poor (final vision > 20/40 in two patients only). Literature review identified 16 well-documented cases of granulomatosis with polyangiitis–related isolated optic neuropathies. Magnetic resonance imaging revealed no abnormality (n = 6), optic nerve and/or sheath involvement (n = 9), apex infiltration (n = 3), and/or pachymeningitis (n = 7). Conclusion: Granulomatosis with polyangiitis is a rare yet potentially blinding cause of inflammatory optic neuropathy. Optic neuropathy in granulomatosis with polyangiitis may occur in the absence of systemic symptoms of disease activity and is challenging to distinguish from other inflammatory and non-inflammatory disorders affecting visual acuity. Several clinical and imaging clues suggest that optic neuropathy results from the development of an extravascular granulomatous process within the optic nerve sheath in the orbital apex, a place that is difficult to image. In a granulomatosis with polyangiitis patient with unexplained visual loss and a seemingly normal workup (fundoscopy, biology, and imaging), clinician should keep a high index of suspicion.

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