35°C Hypothermia Can Reduce Increased Intracranial Pressure as Well as 33°C Hypothermia in Patients with Severe Traumatic Brain Injury 845

2009 ◽  
Vol 10 (3) ◽  
pp. 280-286 ◽  
Author(s):  
Kristine H. O’Phelan ◽  
Dalnam Park ◽  
Jimmy T. Efird ◽  
Katherine Johnson ◽  
Melanie Albano ◽  
...  

2012 ◽  
Vol 23 (2) ◽  
pp. 186-203
Author(s):  
Patricia A. Blissitt

Despite progress in the management of adults with severe traumatic brain injury, several controversies persist. Among the unresolved issues of greatest concern to neurocritical care clinicians and scientists are the following: (1) the best use of technological advances and the data obtained from multimodality monitoring; (2) the use of mannitol and hypertonic saline in the management of increased intracranial pressure; (3) the use of decompressive craniectomy and barbiturate coma in refractory increased intracranial pressure; (4) therapeutic hypothermia as a neuroprotectant; (5) anemia and the role of blood transfusion; and (6) venous thromboembolism prophylaxis in severe traumatic brain injury. Each of these strategies for managing severe traumatic brain injury, including the postulated mechanism(s) of action and beneficial effects of each intervention, adverse effects, the state of the science, and critical care nursing implications, is discussed.


Critical Care ◽  
2021 ◽  
Vol 25 (1) ◽  
Author(s):  
Daniel Agustin Godoy ◽  
Rafael Badenes ◽  
Paolo Pelosi ◽  
Chiara Robba

AbstractMaintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.


2019 ◽  
Vol 9 (1) ◽  
Author(s):  
A. Harrois ◽  
◽  
J. R. Anstey ◽  
F. S. Taccone ◽  
A. A. Udy ◽  
...  

Following publication of the original article [1], we were notified that the collaborators’ names part of the “The TBI Collaborative” group has not been indexed in Pubmed. Below the collaborators names full list:


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