scholarly journals Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene

Development ◽  
2007 ◽  
Vol 134 (7) ◽  
pp. 1357-1368 ◽  
Author(s):  
C. W. Maurer ◽  
M. Chiorazzi ◽  
S. Shaham
Keyword(s):  
Cell Death ◽  
C Elegans ◽  
Encoding Gene ◽  
Developmental Cell Death ◽  
Transcriptional Induction

scholarly journals HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Maxime J Kinet ◽  
Jennifer A Malin ◽  
Mary C Abraham ◽  
Elyse S Blum ◽  
Melanie R Silverman ◽  
...  
Keyword(s):  
Cell Death ◽  
Apoptotic Cell ◽  
Ubiquitin Proteasome System ◽  
Mitogen Activated Protein Kinase ◽  
Death Process ◽  
Heat Shock Factor 1 ◽  
Vertebrate Development ◽  
C Elegans ◽  
Ubiquitin Proteasome ◽  
Developmental Cell Death

Apoptosis is a prominent metazoan cell death form. Yet, mutations in apoptosis regulators cause only minor defects in vertebrate development, suggesting that another developmental cell death mechanism exists. While some non-apoptotic programs have been molecularly characterized, none appear to control developmental cell culling. Linker-cell-type death (LCD) is a morphologically conserved non-apoptotic cell death process operating in Caenorhabditis elegans and vertebrate development, and is therefore a compelling candidate process complementing apoptosis. However, the details of LCD execution are not known. Here we delineate a molecular-genetic pathway governing LCD in C. elegans. Redundant activities of antagonistic Wnt signals, a temporal control pathway, and mitogen-activated protein kinase kinase signaling control heat shock factor 1 (HSF-1), a conserved stress-activated transcription factor. Rather than protecting cells, HSF-1 promotes their demise by activating components of the ubiquitin proteasome system, including the E2 ligase LET-70/UBE2D2 functioning with E3 components CUL-3, RBX-1, BTBD-2, and SIAH-1. Our studies uncover design similarities between LCD and developmental apoptosis, and provide testable predictions for analyzing LCD in vertebrates.

scholarly journals Author response: HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans

2016 ◽  
Author(s):  
Maxime J Kinet ◽  
Jennifer A Malin ◽  
Mary C Abraham ◽  
Elyse S Blum ◽  
Melanie R Silverman ◽  
...  
Keyword(s):  
Cell Death ◽  
Ubiquitin Proteasome System ◽  
Author Response ◽  
C Elegans ◽  
Ubiquitin Proteasome ◽  
Developmental Cell Death

scholarly journals Transcriptional control of non-apoptotic developmental cell death in C. elegans

2016 ◽  
Vol 23 (12) ◽  
pp. 1985-1994 ◽  
Author(s):  
Jennifer A Malin ◽  
Maxime J Kinet ◽  
Mary C Abraham ◽  
Elyse S Blum ◽  
Shai Shaham
Keyword(s):  
Cell Death ◽  
Transcriptional Control ◽  
C Elegans ◽  
Developmental Cell Death

scholarly journals BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9/bcl-2 transcription

Development ◽  
2021 ◽  
Author(s):  
Hang-Shiang Jiang ◽  
Piya Ghose ◽  
Hsiao-Fen Han ◽  
Yun-Zhe Wu ◽  
Ya-Yin Tsai ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Fate ◽  
B Lymphocyte ◽  
Developmental Timing ◽  
Regulatory Sequences ◽  
C Elegans ◽  
Tail Spike ◽  
Gene Regulatory ◽  
Developmental Cell Death ◽  
Common Cell

Programmed cell death (PCD) is a common cell fate in metazoan development. PCD effectors are extensively studied, but how they are temporally regulated is less understood. Here we report a mechanism controlling tail-spike cell death onset during C. elegans development. We show that the Zn-finger transcription factor BLMP-1/Blimp1, which controls larval development timing, also regulates embryonic tail-spike cell death initiation. BLMP-1 functions upstream of CED-9/BCL-2 and in parallel to DRE-1/FBXO11, another CED-9 and tail-spike cell death regulator. BLMP-1 expression is detected in the tail-spike cell shortly after the cell is born, and blmp-1 mutations promote ced-9-dependent tail-spike cell survival. BLMP-1 binds ced-9/bcl-2 gene regulatory sequences, and inhibits ced-9 transcription just before cell-death onset. BLMP-1 and DRE-1 function together to regulate developmental timing, and their mammalian homologs regulate B-lymphocyte fate. Our results, therefore, identify roles for developmental timing genes in cell-death initiation, and suggest conservation of these functions.

scholarly journals c-junIs Dispensable for Developmental Cell Death and Axogenesis in the Retina

1999 ◽  
Vol 19 (11) ◽  
pp. 4349-4359 ◽  
Author(s):  
Karl-Heinz Herzog ◽  
Shu-Cheng Chen ◽  
James I. Morgan
Keyword(s):  
Cell Death ◽  
Developmental Cell Death

scholarly journals Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos

2015 ◽  
Vol 35 (3) ◽  
Author(s):  
Hsiang Yu ◽  
Huey-Jen Lai ◽  
Tai-Wei Lin ◽  
Szecheng J. Lo
Keyword(s):  
Cell Death ◽  
Caenorhabditis Elegans ◽  
Fluorescence Probes ◽  
Dna Fragments ◽  
Dnase Ii ◽  
C Elegans ◽  
Dying Cells

The method of ToLFP (topoisomerase labelled fluorescence probes) is useful for detecting the DNA fragments generated by DNase II in Caenorhabditis elegans embryos. It reveals ~70% ToLFP signals in dying cells and 30% in engulfing cells during embryogenesis.

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