scholarly journals Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina

Development ◽  
2014 ◽  
Vol 141 (16) ◽  
pp. 3243-3254 ◽  
Author(s):  
K. A. Maurer ◽  
A. N. Riesenberg ◽  
N. L. Brown
Keyword(s):  
Notch Signaling ◽  
Mouse Retina ◽  
Distal Mouse

The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina

2009 ◽  
Vol 89 (4) ◽  
pp. 549-558 ◽  
Author(s):  
Akihiko Muto ◽  
Atsumi Iida ◽  
Shinya Satoh ◽  
Sumiko Watanabe
Keyword(s):  
Notch Signaling ◽  
Glial Cell ◽  
Cell Development ◽  
Mouse Retina ◽  
Müller Glial Cell ◽  
Sox Genes

scholarly journals The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina

Cell Reports ◽  
2017 ◽  
Vol 19 (2) ◽  
pp. 351-363 ◽  
Author(s):  
Taejeong Ha ◽  
Kyeong Hwan Moon ◽  
Le Dai ◽  
Jun Hatakeyama ◽  
Keejung Yoon ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Notch Signaling ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Mouse Retina

scholarly journals BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis

Blood ◽  
2012 ◽  
Vol 119 (11) ◽  
pp. 2688-2698 ◽  
Author(s):  
Hidetaka Ohnuki ◽  
Hirofumi Inoue ◽  
Nobuaki Takemori ◽  
Hironao Nakayama ◽  
Tomohisa Sakaue ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Zinc Finger Protein ◽  
E3 Ligase ◽  
Cell Number ◽  
Lymphocytic Leukemia ◽  
Mouse Retina ◽  
Binding Factor ◽  
Factor C ◽  
Endothelial Growth Factor

Abstract Angiogenic homeostasis is maintained by a balance between vascular endothelial growth factor (VEGF) and Notch signaling in endothelial cells (ECs). We screened for molecules that might mediate the coupling of VEGF signal transduction with down-regulation of Notch signaling, and identified B-cell chronic lymphocytic leukemia/lymphoma6-associated zinc finger protein (BAZF). BAZF was induced by VEGF-A in ECs to bind to the Notch signaling factor C-promoter binding factor 1 (CBF1), and to promote the degradation of CBF1 through polyubiquitination in a CBF1-cullin3 (CUL3) E3 ligase complex. BAZF disruption in vivo decreased endothelial tip cell number and filopodia protrusion, and markedly abrogated vascular plexus formation in the mouse retina, overlapping the retinal phenotype seen in response to Notch activation. Further, impaired angiogenesis and capillary remodeling were observed in skin-wounded BAZF−/− mice. We therefore propose that BAZF supports angiogenic sprouting via BAZF-CUL3-based polyubiquitination-dependent degradation of CBF1 to down-regulate Notch signaling.

The Role of Activated NOTCH Signaling in Childhood T-ALL

2010 ◽  
Vol 223 (01) ◽  
Author(s):  
AE Kulozik ◽  
C Kox ◽  
M Remke ◽  
S Breit ◽  
M Zimmermann ◽  
...  
Keyword(s):  
Notch Signaling

Notch signaling participates in liver fibrosis

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
HL Weng ◽  
Y Liu ◽  
Z Shen ◽  
MY Xu ◽  
R Liebe ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Notch Signaling

Activation of the NOTCH signaling pathway stimulates migration of human b-lymphocytes

Pneumologie ◽  
2015 ◽  
Vol 69 (05) ◽  
Author(s):  
A Holzer ◽  
K Watzinger ◽  
CM Kähler
Keyword(s):  
Notch Signaling ◽  
Signaling Pathway ◽  
B Lymphocytes ◽  
Notch Signaling Pathway

New insights into mechanism of Notch signaling in hidradenitis suppurativa

2020 ◽  
Vol 155 (4) ◽  
Author(s):  
Emanuele Scala ◽  
Anna Balato ◽  
Claudio Marasca ◽  
Roberta Di Caprio ◽  
Annunziata Raimondo ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Hidradenitis Suppurativa
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