scholarly journals Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe

Development ◽  
2016 ◽  
Vol 143 (23) ◽  
pp. 4495-4508 ◽  
Author(s):  
Maarja Haugas ◽  
Laura Tikker ◽  
Kaia Achim ◽  
Marjo Salminen ◽  
Juha Partanen
Keyword(s):  
Dorsal Raphe ◽  
Glutamatergic Neuron ◽  
Dorsal Raphé

Author response for "The Mouse Dorsal Raphe Nucleus as Understood by Temporal Fgf8 Lineage Analysis"

2020 ◽  
Author(s):  
Herminio M. Guajardo ◽  
Paul G. Hatini ◽  
Kathryn G. Commons
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Author Response ◽  
Dorsal Raphé ◽  
Lineage Analysis

Buspirone-induced changes in the serotonergic and non-serotonergic cells in the dorsal raphe nucleus of rats

2010 ◽  
Vol 473 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Ali Jahanshahi ◽  
Lee Wei Lim ◽  
Harry W.M. Steinbusch ◽  
Veerle Visser-Vandewalle ◽  
Yasin Temel
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Induced Changes ◽  
Dorsal Raphé

027 GABAergic Neurons in the Dorsal Raphe Nucleus Are under the Influence of GABAergic Inputs from the Nucleus Pontis Oralis

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A12-A12
Author(s):  
Jianhua Zhang ◽  
Mingchu Xi ◽  
Simon Fung ◽  
Charles Tobin ◽  
Sharon Sampogna ◽  
...  
Keyword(s):  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Gabaergic Neurons ◽  
Fluorescent Labeling ◽  
Raphe Nucleus ◽  
Gaba A ◽  
Adult Cats ◽  
Immunohistochemical Techniques ◽  
Fluorescence Immunohistochemistry ◽  
Dorsal Raphé

Abstract Introduction Our previous study has shown that there is a direct connection between GABAergic neurons in the nucleus pontis oralis (NPO) and neurons of the dorsal raphe nucleus (DR), providing a morphological basis for the hypothesis that GABAergic inhibitory processes in NPO play an important role in the generation and maintenance of wakefulness as well as active (REM) sleep through the interaction with neurons in the DR. However, the target of such a GABAergic projection from the NPO within the DR is unknown. In the present study, a double-fluorescent labeling technique was employed to examine the target of GABAergic inputs to the DR. Methods Adult cats were deeply anesthetized and perfused transcardially. Subsequently, the brainstem containing the DR was removed, postfixed and cut into 15 μm coronal sections with a Reichert-Jung cryostat. The sections were immunostained with antibodies against GABA-A or GABA-B receptors and GABA following the procedure of double fluorescence immunohistochemistry. Results Under fluorescence microscopy, a large number of neurons were labeled with antibodies against either GABA-A receptor or GABA-B receptor. In addition, neurons labeled with antibody against GABA were observed in the DR. With double fluorescence immunohistochemical techniques, some neurons labeled by anti-GABA antibody were also stained with antibodies against GABA-A or GABA-B receptors. Conclusion The expression of GABA-A or GABA-B receptors by GABAergic neurons in the DR indicates that GABAergic neurons in the DR receive GABAergic inputs. Our previous study has demonstrated that these GABAergic inputs are from the NPO. These data provide a morphological foundation to support our hypothesis that, during wakefulness, NPO GABAergic “Executive” neurons suppress “Second-Order” GABAergic neurons in the DR, which, in turn, activate (disinhibit) serotonergic wake-on neurons in this nucleus. Support (if any) NS092383

scholarly journals Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aude Muzerelle ◽  
Mariano Soiza-Reilly ◽  
Cornelia Hainer ◽  
Pierre-Louis Ruet ◽  
Klaus-Peter Lesch ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Dorsal Raphe ◽  
Normal Mammary Gland ◽  
Knock Out ◽  
Maternal Experience ◽  
Pup Retrieval ◽  
Pup Survival ◽  
Gland Development ◽  
Severe Growth ◽  
Dorsal Raphé

AbstractProper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.

Serotonin2B receptors exert a GABA-mediated inhibitory control on dorsal raphe nucleus serotonin neuron activity: a microdialysis study in the rat

2019 ◽  
Vol 29 ◽  
pp. S232
Author(s):  
U. Spampinato ◽  
A. Cathala ◽  
C. Devroye ◽  
J.M. Revest ◽  
F. Artigas
Keyword(s):  
Inhibitory Control ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Raphe Nucleus ◽  
Neuron Activity ◽  
Microdialysis Study ◽  
Dorsal Raphé

The influence of electrical stimulation on dorsal raphe nucleus with different current intensities on morphine-induced conditioned place preference in male rats

2015 ◽  
Vol 67 (5) ◽  
pp. 832-836 ◽  
Author(s):  
Gholam Reza Ghavipanjeh ◽  
Ali Asghar Pourshanazari ◽  
Hojjatllah Alaei ◽  
Sara Karimi
Keyword(s):  
Electrical Stimulation ◽  
Conditioned Place Preference ◽  
Dorsal Raphe Nucleus ◽  
Dorsal Raphe ◽  
Place Preference ◽  
Raphe Nucleus ◽  
Male Rats ◽  
Dorsal Raphé
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