scholarly journals First person – Federico Pecori

2020 ◽  
Vol 133 (20) ◽  
pp. jcs255166
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Cell Biology ◽  
Embryonic Stem ◽  
Early Career ◽  
First Person ◽  
Receptor Endocytosis ◽  
Early Career Researchers ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Federico Pecori is first author on ‘Mucin-type O-glycosylation controls pluripotency in mouse embryonic stem cells via Wnt receptor endocytosis’, published in JCS. Federico is a PhD student in the lab of Shoko Nishihara at the Laboratory of Cell Biology, Department of Bioinformatics, Soka University, Tokyo, Japan, where he is interested in the mechanisms regulating stem cell identity.

scholarly journals First person – Sapna Chhabra

Biology Open ◽  
2021 ◽  
Vol 10 (9) ◽  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Early Career ◽  
First Person ◽  
Variable Environment ◽  
Early Career Researchers ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Sapna Chhabra is first author on ‘ BMP-treated human embryonic stem cells transcriptionally resemble amnion cells in the monkey embryo’, published in BiO. Sapna is a postdoc in the lab of Alexander Aulehla at EMBL Heidelberg, Germany, investigating how organisms develop robustly in a variable environment.

scholarly journals First person – Kira Allmeroth

2021 ◽  
Vol 134 (9) ◽  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Early Career ◽  
First Person ◽  
Max Planck ◽  
Stem Cell Fate ◽  
Early Career Researchers ◽  
Hair Follicle Stem Cell ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Kira Allmeroth is first author on ‘ N1-acetylspermidine is a determinant of hair follicle stem cell fate’, published in JCS. Kira conducted the research described in this article while a PhD student in Martin Denzel's lab at the Max Planck Insitute for Biology of Ageing, Cologne, Germany. She is now a postdoc in the Denzel lab, investigating stem cells and metabolism.

scholarly journals First person – Agathe Chaigne

2021 ◽  
Vol 134 (14) ◽  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Biology ◽  
Three Dimensional ◽  
Early Career ◽  
First Person ◽  
Early Career Researchers ◽  
University College London ◽  
Molecular Cell Biology ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Agathe Chaigne is first author on ‘ Three-dimensional geometry controls division symmetry in stem cell colonies’, published in JCS. Agathe is a postdoc in the lab of Ewa Paluch at the MRC Laboratory for Molecular Cell Biology (LMCB), University College London, London, UK, investigating the crosstalk between cell division and cell fate transitions during development.

scholarly journals Future leader to watch – Aaron Savage

Biology Open ◽  
2021 ◽  
Vol 10 (10) ◽  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Regenerative Medicine ◽  
Cell Biology ◽  
Early Career ◽  
Stem Cell Biology ◽  
Early Career Researchers ◽  
Research Associate ◽  
Postdoctoral Research ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Aaron Savage is first author on ‘ Germline competent mesoderm: the substrate for vertebrate germline and somatic stem cells?’, published in BiO. Aaron is a postdoctoral research associate at the Biodiscovery Institute, University of Nottingham, United Kingdom, investigating how stem cells can be used in regenerative medicine and how we can understand stem cell biology using embryonic and post-embryonic development.

First person – Anne Janssen

2021 ◽  
Vol 134 (19) ◽  
Keyword(s):  
The Netherlands ◽  
Nuclear Envelope ◽  
Human Disease ◽  
Cell Biology ◽  
Early Career ◽  
First Person ◽  
Selective Autophagy ◽  
Early Career Researchers ◽  
Selection Of

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Anne Janssen is first author on ‘ Direct observation of aggregate-triggered selective autophagy in human cells’, published in JCS. Anne conducted the research described in this article while a PhD student in Lukas Kapitein's lab at Division of Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands. She is now a FEBS long-term fellow in the lab of Delphine Larrieu at Cambridge Institute for Medical Research, Cambridge, UK, where she is currently interested in the nuclear envelope and how problems in maintaining nuclear integrity can cause human disease.

scholarly journals First person – Maayan Barnea-Zohar and Sabina E. Winograd-Katz

2021 ◽  
Vol 134 (9) ◽  
Keyword(s):  
Cell Size ◽  
Cell Fusion ◽  
Cell Biology ◽  
Early Career ◽  
First Person ◽  
Research Assistant ◽  
Weizmann Institute ◽  
Early Career Researchers ◽  
Selection Of ◽  
Dependent Mechanism

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Maayan Barnea-Zohar and Sabina E. Winograd-Katz are co-first authors on ‘ An SNX10-dependent mechanism downregulates fusion between mature osteoclasts’, published in JCS. Maayan is a research assistant in the lab of Ari Elson at the Weizmann Institute of Science, Rehovot, Israel, investigating cell–cell fusion in osteoclasts and how cell size is determined. Sabina is a research assistant and lab manager in the lab of Benjamin Geiger at the Weizmann Institute of Science, investigating cell biology and signaling.

scholarly journals First person – Nuno Martins, Fernanda Cisneros-Soberanis and Elisa Pesenti

2020 ◽  
Vol 133 (14) ◽  
pp. jcs251124
Keyword(s):  
Chromosome Segregation ◽  
Cell Biology ◽  
Artificial Chromosome ◽  
Early Career ◽  
Human Artificial Chromosome ◽  
First Person ◽  
Artificial Chromosomes ◽  
Early Career Researchers ◽  
University Of Edinburgh ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Nuno Martins, Fernanda Cisneros-Soberani and Elisa Pesenti are co-first authors on ‘H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory’, published in JCS. Nuno conducted the research described in this article while a PhD student in William C. Earnshaw's lab at the Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK. He is now a postdoc in the lab of Ting Wu at Harvard Medical School, Boston, USA, where his research interests lie in the structural and dynamic chromatin regulation of the more mysterious regions of the cell nucleus, such as centromeres, repetitive elements and nucleoli. Fernanda conducted the research described in this article while a postdoc in William C. Earnshaw's lab. She is now an Investigadora en Ciencias Médicas in the lab of Luis Alonso Herrera at Instituto Nacional de Cancerología, México City, México, investigating the transcriptional regulation of microRNAs in breast cancer. Elisa is a postdoc/lab manager in the lab of William C. Earnshaw and is interested in developing human artificial chromosomes (HACs) by applying molecular and synthetic biology techniques to study chromosome segregation and epigenetics in human cells.

scholarly journals First person – Sarita Hebbar and Malte Lehmann

Biology Open ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. bio058519
Keyword(s):  
Metabolic Pathways ◽  
Cell Biology ◽  
Early Career ◽  
First Person ◽  
Max Planck ◽  
Early Career Researchers ◽  
Splicing Regulator ◽  
Inflammatory Bowel ◽  
Molecular Cell Biology ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Sarita Hebbar and Malte Lehmann are co-first authors on ‘Mutations in the splicing regulator Prp31 lead to retinal degeneration in Drosophila’, published in BiO. Sarita is a post-doctoral fellow in the lab of Elisabeth Knust at the Max Planck Institute of Molecular Cell Biology & Genetics, investigating how the same metabolic pathways regulate temporally distinct processes (in morphogenesis and later in tissue homoestasis). Malte is a post-doctoral researcher and physician in the lab of R. G. Kühl and A. G. Siegmund at Charité, Universitätsmedizin Berlin, investigating the mechanisms behind inflammation in Inflammatory Bowel Disease patients.

scholarly journals First person – Marion Lechable and Alexandre Jan

Biology Open ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. bio057034
Keyword(s):  
Cell Biology ◽  
Genetic Model ◽  
Early Career ◽  
Stem Cell Biology ◽  
First Person ◽  
Marie Curie ◽  
Early Career Researchers ◽  
Whole Life Cycle ◽  
Culture Protocol ◽  
Selection Of

ABSTRACTFirst Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers. Marion Lechable and Alexandre Jan are co-first authors on ‘An improved whole life cycle culture protocol for the hydrozoan genetic model Clytia hemisphaerica’, published in BiO. Marion is a Marie-Curie Sklodowska PhD student (ARDRE doctoral programme) in the lab of Professor Bert Hobmayer at University of Innsbruck, Institute of Zoology, Austria, investigating stem cell biology, regeneration, aging and cnidarians models. Alexandre was an engineer assistant in the lab of Dr Tsuyoshi Momose at Laboratoire de Biologie du Développement, at the Institut de la Mer de Villefranche, France, investigating capture breeding, cnidarians models, gelatinous plankton, improving culturing protocols and regeneration.

High-content screening of small compounds on human embryonic stem cells

2010 ◽  
Vol 38 (4) ◽  
pp. 1046-1050 ◽  
Author(s):  
Ivana Barbaric ◽  
Paul J. Gokhale ◽  
Peter W. Andrews
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
High Throughput ◽  
Cell Biology ◽  
Es Cells ◽  
Embryonic Stem ◽  
High Content Screening ◽  
Cellular Models ◽  
Compound Libraries

Human ES (embryonic stem) cells and iPS (induced pluripotent stem) cells have been heralded as a source of differentiated cells that could be used in the treatment of degenerative diseases, such as Parkinson's disease or diabetes. Despite the great potential for their use in regenerative therapy, the challenge remains to understand the basic biology of these remarkable cells, in order to differentiate them into any functional cell type. Given the scale of the task, high-throughput screening of agents and culture conditions offers one way to accelerate these studies. The screening of small-compound libraries is particularly amenable to such high-throughput methods. Coupled with high-content screening technology that enables simultaneous assessment of multiple cellular features in an automated and quantitative way, this approach is proving powerful in identifying both small molecules as tools for manipulating stem cell fates and novel mechanisms of differentiation not previously associated with stem cell biology. Such screens performed on human ES cells also demonstrate the usefulness of human ES/iPS cells as cellular models for pharmacological testing of drug efficacy and toxicity, possibly a more imminent use of these cells than in regenerative medicine.

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