Inducible NO synthase: role in cellular signalling
1999 ◽
Vol 202
(6)
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pp. 645-653
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Keyword(s):
The Past
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The discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO) was one of the most exciting discoveries of biomedical research in the 1980s. Besides its potent vasodilatory effects, NO was found under certain circumstances to be responsible for the killing of microorganisms and tumour cells by activated macrophages and to act as a novel, unconventional type of neurotransmitter. In 1992, Science picked NO as the ‘Molecule of the Year’, and over the past years NO has become established as a universal intercellular messenger that acutely affects important signalling pathways and, on a more long-term scale, modulates gene expression in target cells. These actions will form the focus of the present review.
1999 ◽
Vol 41
(3)
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pp. 672-681
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1994 ◽
Vol 267
(6)
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pp. H2523-H2530
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1993 ◽
Vol 90
(23)
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pp. 11411-11415
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Keyword(s):
1993 ◽
Vol 75
(1)
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pp. 424-431
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1993 ◽
Vol 265
(4)
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pp. H1139-H1148
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1994 ◽
Vol 267
(3)
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pp. F374-F379
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1995 ◽
Vol 268
(2)
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pp. C520-C526
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1994 ◽
Vol 428
(3-4)
◽
pp. 261-268
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Keyword(s):