scholarly journals BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Cancer

2012 ◽  
Vol 20 (1) ◽  
pp. 3-4 ◽  
Author(s):  
Martha A. Zeiger ◽  
Eric B. Schneider
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Central Compartment ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Node Metastasis

BRAF V600E Mutation Independently Predicts Central Compartment Lymph Node Metastasis in Patients with Papillary Thyroid Cancer

2012 ◽  
Vol 20 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Gina M. Howell ◽  
Marina N. Nikiforova ◽  
Sally E. Carty ◽  
Michaele J. Armstrong ◽  
Steven P. Hodak ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Central Compartment ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Node Metastasis

BRAF V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer

2021 ◽  
Author(s):  
Yubing Tao ◽  
Fei Wang ◽  
Xiaopei Shen ◽  
Guangwu Zhu ◽  
Rengyun Liu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Mortality Risk ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Wild Type ◽  
Node Metastasis ◽  
Multivariate Adjustment

Abstract Context How lymph node metastasis (LNM)-associated mortality risk is affected by BRAF V600E in papillary thyroid cancer (PTC) remains undefined. Objective To study whether BRAF V600E affected LNM-associated mortality in PTC. Design, Setting, Participants We retrospectively analyzed the effect of LNM on PTC-specific mortality with respect to BRAF status in 2638 patients (2015 females and 623 males) from 11 centers in 6 countries, with median age of 46 (IQR 35–58) years and median follow-up time of 58 (IQR 26–107) months. Results Overall, LNM showed a modest mortality risk in wild-type BRAF patients but a strong one in BRAFV600E patients. In conventional PTC (CPTC), LNM showed no increased mortality risk in wild-type BRAF patients but a robustly increased one in BRAFV600E patients; mortality rates were 2/659 (0.3%) versus 4/321 (1.2%) in non-LNM versus LNM patients (P=0.094) with wild-type BRAF, corresponding to a hazard ratio (HR) (95% CI) of 4.37 (0.80-23.89), which remained insignificant at 3.32 (0.52-21.14) after multivariate adjustment. In BRAFV600E CPTC, morality rates were 7/515 (1.4%) versus 28/363 (7.7%) in non-LNM versus LNM patients (P<0.001), corresponding to HR of 4.90 (2.12-11.29) or, after multivariate adjustment, 5.76 (2.19-15.11). Adjusted mortality HR of coexisting LNM and BRAFV600E versus absence of both was 27.39 (5.15-145.80), with Kaplan-Meier analyses showing a similar synergism. Conclusions LNM-associated mortality risk is sharply differentiated by the BRAF status in PTC; in CPTC, LNM showed no increased mortality risk with wild-type BRAF but a robust one with BRAF mutation. These results have strong clinical relevance.

TSHR rs2288496 associated with thyroid hormone and predict the occurrence of lymph node metastasis of papillary thyroid cancer

2019 ◽  
Vol 26 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Xuan Su ◽  
Li-Wen Lin ◽  
Jie-Ling Weng ◽  
Shu-Wei Chen ◽  
Xin-Hua Yang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Thyroid Hormone ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Node Metastasis

Association between the HLA-G molecule and lymph node metastasis in papillary thyroid cancer

2013 ◽  
Vol 74 (4) ◽  
pp. 447-451 ◽  
Author(s):  
Larissa Mesquita Nunes ◽  
Flávio Monteiro Ayres ◽  
Isadora Carvalho Medeiros Francescantonio ◽  
Vera Aparecida Saddi ◽  
Melissa Ameloti Gomes Avelino ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Node Metastasis
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