Spectral Studies and In Vitro Antimicrobial Activity of New Organotin(IV) Complexes of Schiff Bases Derived from Amino Acids

New series of organotin(IV) complexes and Schiff bases derived from amino acids have been designed and synthesized from condensation of1H-indole-2,3-dione, 5-chloro-1H-indole-2,3-dione, andα-amino acids (phenylalanine, isoleucine, and glycine). All compounds are characterized by elemental analyses, molar conductance measurements, and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance (1H,13C, and119Sn NMR) spectral studies. The results suggest that Schiff bases behave as monobasic bidentate ligands and coordinate with dibutyltin(IV) in octahedral geometry according to the general formula [Bu2Sn(L)2]. Elemental analyses and NMR spectral data of the ligands with their dibutyltin(IV) complexes agree with their proposed distorted octahedral structures. Few representative compounds are tested for their in vitro antibacterial activity against Gram-positive (B. cereus,Staphylococcusspp.) and Gram-negative (E. coli,Klebsiellaspp.) bacteria. The results show that the dibutyltin complexes are more reactive with respect to their corresponding Schiff base ligands.

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Synthesis, Spectral, andIn VitroAntibacterial Studies of Organosilicon(IV) Complexes with Schiff Bases Derived from Amino Acids

Bioinorganic Chemistry and Applications ◽

10.1155/2013/425832 ◽

2013 ◽

Vol 2013 ◽

pp. 1-9 ◽

Cited By ~ 12

Author(s):

Har Lal Singh ◽

Jangbhadur Singh ◽

A. Mukherjee

Keyword(s):

Escherichia Coli ◽

Amino Acids ◽

Antimicrobial Activity ◽

Schiff Bases ◽

Spectroscopic Studies ◽

Molar Conductance ◽

Molar Ratio ◽

Trigonal Bipyramidal ◽

Antibacterial Evaluation

The present work stems from our interest in the synthesis, characterization, and antibacterial evaluation of organosilicon(IV) complexes of a class of amino-acid-based Schiff base which have been prepared by the interaction of ethoxytrimethylsilane with the Schiff bases (N OH) in 1 : 1 molar ratio. These complexes have been characterized by elemental analysis, molar conductance, and spectroscopic studies including electronic IR and NMR (1H,13C, and29Si) spectroscopy. The analytical and spectral data suggest trigonal bipyramidal geometry around the silicon atom in the resulting complexes. The ligands and their organosilicon complexes have also been evaluated forin vitroantimicrobial activity against bacteria (Bacillus cereus,Nocardiaspp.,E. aerogenes,Escherichia coli,Klebsiellaspp., andStaphylococcusspp.). The complexes were found to be more potent as compared to the ligands.

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Hypercoordinated Organosilicon(IV) and Organotin(IV) Complexes: Syntheses, Spectral Studies, and Antimicrobial Activity In Vitro

ISRN Inorganic Chemistry ◽

10.1155/2013/356802 ◽

2013 ◽

Vol 2013 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Kiran Singh ◽

Parvesh Puri ◽

Yogender Kumar ◽

Chetan Sharma

Keyword(s):

Antimicrobial Activity ◽

Schiff Bases ◽

Structural Features ◽

Antimicrobial Activities ◽

Molar Conductance ◽

Spectral Studies ◽

Nmr Studies ◽

Trigonal Bipyramidal ◽

Elemental Analyses

This paper deals with the syntheses and structural features of some new diorganosilicon(IV) and diorganotin(IV) complexes having general formulae (CH3)2MCl(L1), (CH3)2MCl(L2), (CH3)2M(L1)2, and (CH3)2M(L2)2 with new Schiff bases (M = Si and Sn). The Schiff bases HL1 and HL2 have been derived from the condensation of 3-bromobenzaldehyde with 4-amino-3-ethyl-5-mercapto-1,2,4-triazole and 4-amino-5-mercapto-3-propyl-1,2,4-triazole, respectively. The compounds have been characterized by the elemental analyses, molar conductance, and spectral (UV, IR, 1H, 13C, 29Si, and 119Sn NMR) studies. The resulting complexes have been proposed to have trigonal bipyramidal and octahedral geometries. In vitro antimicrobial activities of the compounds have been carried out.

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Synthesis and In vitro Antimicrobial Activity of New Schiff Bases of 1,3,4-thiadiazole and 1,2,4-triazole

International Research Journal of Pure and Applied Chemistry ◽

10.9734/irjpac/2015/16459 ◽

2015 ◽

Vol 7 (2) ◽

pp. 69-77

Author(s):

Łukasz Popiołek ◽

Magdalena Matraszek ◽

Paulina Piasecka ◽

Klaudia Pataj ◽

Marcin Bińczak ◽

...

Keyword(s):

Antimicrobial Activity ◽

Schiff Bases ◽

In Vitro Antimicrobial Activity

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Spectral Studies and Bactericidal, Fungicidal, Insecticidal and Parasitological Activities of Organotin(IV) Complexes of Thio Schiff Bases Having no Donor Atoms

Metal-Based Drugs ◽

10.1155/mbd.1995.297 ◽

1995 ◽

Vol 2 (6) ◽

pp. 297-309 ◽

Cited By ~ 20

Author(s):

Mala Nath ◽

Savita Goyal

Keyword(s):

Escherichia Coli ◽

Staphylococcus Aureus ◽

Antimicrobial Activity ◽

Schiff Bases ◽

Thermal Studies ◽

Far Infrared ◽

Trichophyton Mentagrophytes ◽

Spectral Studies ◽

No Donor

Twelve new organotin(IV) complexes of the type RnSnLm [where n = 3, m = 1, R = CH3 or C6H5 ; n = 2, m = 2, R = C6H5 or C4H9 ; L = anion of Schiff bases derived from the condensation of 2-amino-5-(o -anisyl)-l,3,4-thiadiazole with salicylaldehyde (HL-1), 2- hydroxynaphthaldehyde (HL-2) and 2-hydroxyacetophenone (HL-3)] have been synthesized and characterized by elemental analysis, molar conductances, electronic, infrared, far-infrared, H1 NMR and S119n Mössbauer spectral studies. Thermal studies of two complexes, viz., Ph3Sn (L-1) and Ph2Sn(L-2)2 have been carried out in the temperature range 25-1000∘C using TG, DTG and DTA techniques. All these complexes decompose gradually with the formation of SnO2 as an end product. In vitro antimicrobial activity of the Schiff bases and their complexes has also been determined against Streptococcus faecalis, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus Penicillin resistance (2500 units), Candida albicans, Cryptococcus neoformans, Sporotrichum schenckii, Trichophyton mentagrophytes and Aspergillus fumigatus. The Schiff bases (HL-1), (HL-2) and the organotin(IV) compounds have also been tested against various important herbicidal, fungicidal, insecticidal species and also for parasitological activity against freeliving nematode.

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