Farnesyl Diphosphate Synthase Reactions with Dimethylallyl Diphosphate Analogues Having Oxygen Atoms in Their Chains

1995 ◽  
Vol 24 (5) ◽  
pp. 389-390 ◽  
Author(s):  
Yuji Maki ◽  
Masayo Kurihara ◽  
Takae Endo ◽  
Megumi Abiko ◽  
Kazuhiro Saito ◽  
...  
Keyword(s):  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Dimethylallyl Diphosphate ◽  
Oxygen Atoms

ChemInform Abstract: Farnesyl Diphosphate Synthase Reactions with Dimethylallyl Diphosphate Analogues Having Oxygen Atoms in Their Chains.

ChemInform ◽  
2010 ◽  
Vol 26 (40) ◽  
pp. no-no
Author(s):  
Y. MAKI ◽  
M. KURIHARA ◽  
T. ENDO ◽  
M. ABIKO ◽  
K. SAITO ◽  
...  
Keyword(s):  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Dimethylallyl Diphosphate ◽  
Oxygen Atoms

scholarly journals Farnesyl diphosphate synthase; regulation of product specificity.

2005 ◽  
Vol 52 (1) ◽  
pp. 45-55 ◽  
Author(s):  
Anna Szkopińska ◽  
Danuta Płochocka
Keyword(s):  
Environmental Changes ◽  
Gene Families ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Type I ◽  
Isopentenyl Diphosphate ◽  
Product Specificity ◽  
Dimethylallyl Diphosphate ◽  
Key Enzyme ◽  
Synthase Regulation

Farnesyl diphosphate synthase (FPPS) is a key enzyme in isoprenoid biosynthesis which supplies sesquiterpene precursors for several classes of essential metabolites including sterols, dolichols, ubiquinones and carotenoids as well as substrates for farnesylation and geranylgeranylation of proteins. It catalyzes the sequential head-to-tail condensation of two molecules of isopentenyl diphosphate with dimethylallyl diphosphate. The enzyme is a homodimer of subunits, typically having two aspartate-rich motifs with two sets of substrate binding sites for an allylic diphosphate and isopentenyl diphosphate per homodimer. The synthase amino-acid residues at the 4th and 5th positions before the first aspartate rich motif mainly determine product specificity. Hypothetically, type I (eukaryotic) and type II (eubacterial) FPPSs evolved from archeal geranylgeranyl diphosphate synthase by substitutions in the chain length determination region. FPPS belongs to enzymes encoded by gene families. In plants this offers the possibility of differential regulation in response to environmental changes or to herbivore or pathogen attack.

Farnesyl Diphosphate Synthase Reactions of Geranyl Diphosphate Analogues Having Oxygen Atoms in Their Alkyl Chains

1994 ◽  
Vol 23 (10) ◽  
pp. 1841-1844 ◽  
Author(s):  
Yuji Maki ◽  
Hikaru Satoh ◽  
Masayo Kurihara ◽  
Takae Endo ◽  
Gotaro Watanabe ◽  
...  
Keyword(s):  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Geranyl Diphosphate ◽  
Alkyl Chains ◽  
Oxygen Atoms

scholarly journals Maize cDNAs Expressed in Endosperm Encode Functional Farnesyl Diphosphate Synthase with Geranylgeranyl Diphosphate Synthase Activity

2006 ◽  
Vol 141 (1) ◽  
pp. 220-231 ◽  
Author(s):  
Miguel Cervantes-Cervantes ◽  
Cynthia E. Gallagher ◽  
Changfu Zhu ◽  
Eleanore T. Wurtzel
Keyword(s):  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Geranylgeranyl Diphosphate Synthase ◽  
Geranylgeranyl Diphosphate

scholarly journals Inhibitors of Leishmania Major Farnesyl Diphosphate Synthase: Crystallographic and Calorimetric Studies

2011 ◽  
Vol 100 (3) ◽  
pp. 218a-219a
Author(s):  
Srinivas Aripirala ◽  
Sandra Gabelli ◽  
Eric Oldfield ◽  
Dolores Gonzalez Pacanowska ◽  
Mario Amzel
Keyword(s):  
Leishmania Major ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
Calorimetric Studies

scholarly journals Farnesyl Diphosphate Synthase Inhibitors from In Silico Screening

2013 ◽  
Vol 81 (6) ◽  
pp. 742-748 ◽  
Author(s):  
Steffen Lindert ◽  
Wei Zhu ◽  
Yi‐Liang Liu ◽  
Ran Pang ◽  
Eric Oldfield ◽  
...  
Keyword(s):  
In Silico ◽  
Farnesyl Diphosphate ◽  
Farnesyl Diphosphate Synthase ◽  
In Silico Screening
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