Facile Synthesis of Well-dispersed Hollow Mesoporous Silica Nanoparticles Using Iron Oxide Nanoparticles as Template

A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.

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Facile synthesis of PDMAEMA-coated hollow mesoporous silica nanoparticles and their pH-responsive controlled release

Microporous and Mesoporous Materials ◽

10.1016/j.micromeso.2013.02.012 ◽

2013 ◽

Vol 173 ◽

pp. 64-69 ◽

Cited By ~ 49

Author(s):

Faqi Yu ◽

Xinde Tang ◽

Meishan Pei

Keyword(s):

Controlled Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Ph Responsive ◽

Facile Synthesis ◽

Hollow Mesoporous Silica

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Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments

Journal of Chemistry ◽

10.1155/2016/2672740 ◽

2016 ◽

Vol 2016 ◽

pp. 1-15 ◽

Cited By ~ 9

Author(s):

Merlis P. Alvarez-Berríos ◽

Naisha Sosa-Cintron ◽

Mariel Rodriguez-Lugo ◽

Ridhima Juneja ◽

Juan L. Vivero-Escoto

Keyword(s):

Iron Oxide ◽

Side Effects ◽

Mesoporous Silica ◽

Iron Oxide Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Metastatic Cancer ◽

Hybrid Nanoparticles ◽

Future Perspective ◽

Oxide Nanoparticles ◽

Hybrid Nanomaterials

The current approaches used for the treatment of cancer face some clinical limitations such as induction of severe side effects, multidrug resistance (MDR), and low specificity toward metastatic cancer cells. Hybrid nanomaterials hold a great potential to overcome all these challenges. Among hybrid nanoparticles, those based on mesoporous silica and iron oxide nanoparticles (MSNs and IONPs) have gained a privileged place in the biomedical field because of their outstanding properties. There are many studies demonstrating their effectiveness as drug delivery systems, nanoheaters, and imaging contrast agents. This review summarizes the advances related to the utilization of IONPs and MSNs for reducing side effects, overcoming MDR, and inhibiting metastasis. Furthermore, we give a future perspective of the clinical application of these technologies.

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Comparative study on the magnetic properties of iron oxide nanoparticles loaded on mesoporous silica and carbon materials with different structure

Microporous and Mesoporous Materials ◽

10.1016/j.micromeso.2009.01.029 ◽

2009 ◽

Vol 121 (1-3) ◽

pp. 178-184 ◽

Cited By ~ 27

Author(s):

Sher Alam ◽

Chokkalingam Anand ◽

Radhakrishnan Logudurai ◽

Veerappan V. Balasubramanian ◽

Katsuhiko Ariga ◽

...

Keyword(s):

Magnetic Properties ◽

Iron Oxide ◽

Mesoporous Silica ◽

Comparative Study ◽

Iron Oxide Nanoparticles ◽

Carbon Materials ◽

Oxide Nanoparticles

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A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

Journal of Materials Chemistry B ◽

10.1039/c5tb00634a ◽

2015 ◽

Vol 3 (31) ◽

pp. 6480-6489 ◽

Cited By ~ 61

Author(s):

Haijiao Zhang ◽

Huijuan Xu ◽

Minghong Wu ◽

Yufang Zhong ◽

Donghai Wang ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Protein Adsorption ◽

Rough Surfaces ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Delivery ◽

Hard Template ◽

Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

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NIR-absorbing dye functionalized hollow mesoporous silica nanoparticles for combined photothermal–chemotherapy

Chemical Communications ◽

10.1039/c7cc07897h ◽

2017 ◽

Vol 53 (88) ◽

pp. 12032-12035 ◽

Cited By ~ 19

Author(s):

Yuanyuan Zhang ◽

Qiuyu Qu ◽

Xiang Cao ◽

Yanli Zhao

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Anticancer Efficacy ◽

Hollow Mesoporous Silica ◽

Multifunctional Nanocarriers

Multifunctional nanocarriers consisting of hollow mesoporous silica nanoparticles loaded with doxorubicin and then capped by a complex between disulfide linked β-cyclodextrin and adamantane functionalized indocyanine dye are developed for improved anticancer efficacy through combined photothermal–chemotherapy.

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