scholarly journals Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments

2016 ◽  
Vol 2016 ◽  
pp. 1-15 ◽  
Author(s):  
Merlis P. Alvarez-Berríos ◽  
Naisha Sosa-Cintron ◽  
Mariel Rodriguez-Lugo ◽  
Ridhima Juneja ◽  
Juan L. Vivero-Escoto
Keyword(s):  
Iron Oxide ◽  
Side Effects ◽  
Mesoporous Silica ◽  
Iron Oxide Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Metastatic Cancer ◽  
Hybrid Nanoparticles ◽  
Future Perspective ◽  
Oxide Nanoparticles ◽  
Hybrid Nanomaterials

The current approaches used for the treatment of cancer face some clinical limitations such as induction of severe side effects, multidrug resistance (MDR), and low specificity toward metastatic cancer cells. Hybrid nanomaterials hold a great potential to overcome all these challenges. Among hybrid nanoparticles, those based on mesoporous silica and iron oxide nanoparticles (MSNs and IONPs) have gained a privileged place in the biomedical field because of their outstanding properties. There are many studies demonstrating their effectiveness as drug delivery systems, nanoheaters, and imaging contrast agents. This review summarizes the advances related to the utilization of IONPs and MSNs for reducing side effects, overcoming MDR, and inhibiting metastasis. Furthermore, we give a future perspective of the clinical application of these technologies.

Facile Synthesis of Well-dispersed Hollow Mesoporous Silica Nanoparticles Using Iron Oxide Nanoparticles as Template

2013 ◽  
Vol 42 (3) ◽  
pp. 316-317 ◽  
Author(s):  
Takaaki Ikuno ◽  
Atsuro Nomura ◽  
Kenta Iyoki ◽  
Ayae Sugawara-Narutaki ◽  
Tatsuya Okubo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Hollow Mesoporous Silica

scholarly journals Superparamagnetic Iron Oxide Nanoparticles Decorated Mesoporous Silica Nanosystem for Combined Antibiofilm Therapy

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 163
Author(s):  
Elena Álvarez ◽  
Manuel Estévez ◽  
Alvaro Gallo-Cordova ◽  
Blanca González ◽  
Rafael R. Castillo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Iron Oxide Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Viable Bacteria ◽  
Microbiological Assays ◽  
Polymer Capping

A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.

Comparative study on the magnetic properties of iron oxide nanoparticles loaded on mesoporous silica and carbon materials with different structure

2009 ◽  
Vol 121 (1-3) ◽  
pp. 178-184 ◽  
Author(s):  
Sher Alam ◽  
Chokkalingam Anand ◽  
Radhakrishnan Logudurai ◽  
Veerappan V. Balasubramanian ◽  
Katsuhiko Ariga ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Mesoporous Silica ◽  
Comparative Study ◽  
Iron Oxide Nanoparticles ◽  
Carbon Materials ◽  
Oxide Nanoparticles

scholarly journals Hybrid nanoparticles for magnetic and plasmonic hyperthermia

2018 ◽  
Vol 20 (37) ◽  
pp. 24065-24073 ◽  
Author(s):  
Jesus G. Ovejero ◽  
Irene Morales ◽  
Patricia de la Presa ◽  
Nicolas Mille ◽  
Julian Carrey ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Plasmonic Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Oxide Nanoparticles ◽  
Au Nanorods

The present manuscript reports the use of hybrid magneto-plasmonic nanoparticles (HMPNPs) based on iron oxide nanoparticles and Au nanorods as colloidal nanoheaters.

Doxorubicin Loaded Dextran-coated Superparamagnetic Iron Oxide Nanoparticles with Sustained Release Property: Intracellular Uptake, Pharmacokinetics, and Biodistribution Study

2021 ◽  
Vol 22 ◽  
Author(s):  
Houli Li ◽  
Zhiyi Luo ◽  
Mingli Peng ◽  
Lili Guo ◽  
Fuqiang Li ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Side Effects ◽  
Sustained Release ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Intracellular Uptake ◽  
Release Property

Background: Due to the short biological half-life and serious side effects (especially for heart and kidney), the application of Doxorubicin (Dox) in clinical therapy is strictly limited. To overcome these shortcomings, a novel sustained release formulation of doxorubicin-loaded dextran-coated superparamagnetic iron oxide nanoparticles (Dox-DSPIONs) was prepared. Objective: The purpose of this study was to evaluate the intracellular uptake behavior of Dox-DSPIONs and to investigate their pharmacokinetics and biodistribution properties. Method: Confocal laser scanning microscopy was employed to study the intracellular uptake and release properties of Dox from Dox-DSPIONs in SMMC-7721 cells. Simple high-performance liquid chromatography with fluorescence detection (HPLC-FLD) method was established to study the pharmacokinetics and biodistribution properties of Dox-DSPIONs in vivo after intravenous administration and compared with free Dox. Results: Intracellular uptake experiment indicated that Dox could be released sustainedly from Dox-DSPIONs over time. The pharmacokinetics parameters displayed that the T1/2and AUC0-24h of Dox-DSPIONs were higher than those of free Dox, while the Cmax of Dox-DSPIONs was significantly lower than that of free drug. The biodistribution behaviors of the drug were altered by Dox-DSPIONs in mice, which showed obvious liver targeting, and significantly reduced the distribution of the drug in the heart and kidney. Conclusion: Dox-DSPIONs have the sustained-release property in vitro and in vivo, which could significantly prolong blood circulation time, improve bioavailability, and reduce the side effects of Dox. Therefore, the novel formulation of the Dox-DSPIONs has the potential as a promising drug delivery system in cancer therapy.

scholarly journals Nanorods Based on Mesoporous Silica Containing Iron Oxide Nanoparticles as Catalytic Nanomotors: Study of Motion Dynamics

ChemNanoMat ◽  
2020 ◽  
Author(s):  
Rafael Mestre ◽  
Núria Cadefau ◽  
Ana C. Hortelão ◽  
Jan Grzelak ◽  
Martí Gich ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Motion Dynamics

scholarly journals Targeting and Cellular Trafficking of Magnetic Nanoparticles for Prostate Cancer Imaging

2007 ◽  
Vol 6 (4) ◽  
pp. 7290.2007.00025 ◽  
Author(s):  
Rita E. Serda ◽  
Natalie L. Adolphi ◽  
Marco Bisoffi ◽  
Laurel O. Sillerud
Keyword(s):  
Prostate Cancer ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Particles ◽  
Metastatic Cancer ◽  
Confocal Laser ◽  
Oxide Nanoparticles ◽  
Prostate Cancer Cells ◽  
Mr Images

Antibody-conjugated iron oxide nanoparticles offer a specific and sensitive tool to enhance magnetic resonance (MR) images of both local and metastatic cancer. Prostate-specific membrane antigen (PSMA) is predominantly expressed on the neovasculature of solid tumors and on the surface of prostate cells, with enhanced expression following androgen deprivation therapy. Biotinylated anti-PSMA antibody was conjugated to streptavidin-labeled iron oxide nanoparticles and used in MR imaging and confocal laser scanning microscopic imaging studies using LNCaP prostate cancer cells. Labeled iron oxide nanoparticles are internalized by receptor-mediated endocytosis, which involves the formation of clathrin-coated vesicles. Endocytosed particles are not targeted to the Golgi apparatus for recycling but instead accumulate within lysosomes. In T1-weighted MR images, the signal enhancement owing to the magnetic particles was greater for cells with magnetic particles bound to the cell surface than for cells that internalized the particles. However, the location of the particles (surface vs internal) did not significantly alter their effect on T2-weighted images. Our findings indicate that targeting prostate cancer cells using PSMA offers a specific and sensitive technique for enhancing MR images.

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