scholarly journals Lanthanoid complex of iron-transport protein, transferrin - Kinetic study on release of the metal from N and C binding sites.

1988 ◽  
pp. 452-458 ◽  
Author(s):  
Takaki YAMAMURA ◽  
Kaoru ICHIMURA ◽  
To'ru TSUDA ◽  
Atsuko HAYASHI ◽  
Takahiro TANIGUCHI ◽  
...  
Keyword(s):  
Kinetic Study ◽  
Binding Sites ◽  
Iron Transport ◽  
Transport Protein

Characterization and Developmental Expression of Binding Sites for the Transplacental Iron Transport Protein, Uteroferrin, in Fetal Hematopoietic Tissues

Neonatology ◽  
1992 ◽  
Vol 61 (2) ◽  
pp. 82-91 ◽  
Author(s):  
Frank J. Michel ◽  
Maria Filomena V. Fliss ◽  
Fuller W. Bazer ◽  
Rosalia C.M. Simmen
Keyword(s):  
Binding Sites ◽  
Iron Transport ◽  
Transport Protein ◽  
Developmental Expression

An autoradiographical saturation kinetic study of the different benzodiazepine binding sites in rat brain by using [3H] flunitrazepam as a radioligand

1995 ◽  
Vol 50 (10) ◽  
pp. 1619-1625 ◽  
Author(s):  
Carlos Soria ◽  
Victoria Revilla ◽  
Maria Adoración Candelas ◽  
Pedro Calvo ◽  
Arsenio Fernández-López
Keyword(s):  
Kinetic Study ◽  
Rat Brain ◽  
Binding Sites ◽  
Saturation Kinetic ◽  
Benzodiazepine Binding ◽  
Benzodiazepine Binding Sites

Metallomics approach for the identification of the iron transport protein transferrin in the blood of harbour seals (Phoca vitulina)

Metallomics ◽  
2010 ◽  
Vol 2 (10) ◽  
pp. 683 ◽  
Author(s):  
Mechthild Grebe ◽  
Daniel Pröfrock ◽  
Antje Kakuschke ◽  
Jose A.C. Broekaert ◽  
Andreas Prange
Keyword(s):  
Iron Transport ◽  
Phoca Vitulina ◽  
Transport Protein ◽  
Harbour Seals

Lactoferrin – 50 years on

2012 ◽  
Vol 90 (3) ◽  
pp. 245-251 ◽  
Author(s):  
Jeremy H. Brock
Keyword(s):  
Gastrointestinal Tract ◽  
Antimicrobial Agent ◽  
Iron Transport ◽  
Iron Absorption ◽  
Structure And Function ◽  
Transport Protein ◽  
Future Research ◽  
Iron Binding ◽  
Plasma Iron ◽  
And Function

It is now some 50 years since iron-binding lactoferrin was first isolated and purified, an event that opened the way to subsequent extensive research on lactoferrin structure and function. The initial recognition that lactoferrin closely resembled the plasma iron-transport protein transferrin meant that lactoferrin was first thought to mediate intestinal iron absorption or to act as an antimicrobial agent. It was also suggested that it could mediate the hyposideraemia of inflammation. This paper will assess to what extent early proposals have stood the test of time and also suggest possible mechanisms by which lactoferrin can mediate the large number of potential functions that have subsequently been proposed. It will also review the ability of lactoferrin to resist digestion in the gastrointestinal tract and identify areas for future research.

scholarly journals Demonstration of transferrin receptors on human placental trophoblast

Blood ◽  
1980 ◽  
Vol 55 (2) ◽  
pp. 240-242 ◽  
Author(s):  
GM Galbraith ◽  
RM Galbraith ◽  
A Temple ◽  
WP Faulk
Keyword(s):  
Binding Sites ◽  
Iron Transport ◽  
Transferrin Receptors ◽  
Transplacental Passage ◽  
Chorionic Villi ◽  
Characteristic Distribution ◽  
Maternal Iron ◽  
Phosphate Buffered Saline

Abstract It has been postulated that the transplacental passage of maternal iron to the developing fetus requires binding of maternal transferrin to the trophoblast. We have therefore examined the ability of the human placenta to bind transferrin in vitro. Transferrin was demonstrated on trophoblast of human chorionic villi by immunohistologic methods. Moreover, after removal of transferrin bound in vivo by treatment of tissue with chaotropic solution or phosphate-buffered saline, freshly added transferrin was shown to bind in vitro in the same characteristic distribution. These findings suggest that placental iron transport is initiated by uptake of maternal transferrin iron to specific trophoblast binding sites.

scholarly journals A recombinant iron transport protein fromBordetella pertussisconfers protection againstBordetella parapertussis

2017 ◽  
Vol 61 (10) ◽  
pp. 407-415 ◽  
Author(s):  
Jimena Alvarez Hayes ◽  
Juan Marcos Oviedo ◽  
Hugo Valdez ◽  
Juan Martín Laborde ◽  
Fabricio Maschi ◽  
...  
Keyword(s):  
Iron Transport ◽  
Transport Protein

scholarly journals Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

2012 ◽  
Vol 205 (7) ◽  
pp. 1043-1047 ◽  
Author(s):  
Meghan A. Baker ◽  
Douglas Wilson ◽  
Kristina Wallengren ◽  
Andreas Sandgren ◽  
Oleg Iartchouk ◽  
...  
Keyword(s):  
Iron Transport ◽  
Transport Protein ◽  
Ferroportin 1

scholarly journals A kinetic study of pig liver pyruvate kinase activated by fructose diphosphate

1974 ◽  
Vol 139 (3) ◽  
pp. 499-508 ◽  
Author(s):  
Neil Macfarlane ◽  
Stanley Ainsworth
Keyword(s):  
Kinetic Study ◽  
Pyruvate Kinase ◽  
Binding Sites ◽  
Experimental Results ◽  
Enzyme Complex ◽  
Pig Liver ◽  
Michaelis Constants ◽  
Inhibition Constants ◽  
Complex Forms

The paper reports a study of the reaction between phosphoenolpyruvate, ADP and Mg2+ catalysed by pig liver pyruvate kinase when activated by fructose diphosphate and K+. The experimental results are consistent with two non-sequential mechanisms in which the substrates and products of the reaction are phosphoenolpyruvate, ADP, Mg2+, pyruvate and MgATP. Pyruvate release occurs before ADP binding. Two Mg2+ ions are involved, though the two Mg2+-binding sites cannot be occupied simultaneously. An isomerized enzyme complex forms before release of MgATP. Values were determined for the Michaelis constants of the reaction. Apparent MgATP inhibition constants are also given.

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