scholarly journals Mitogenic Activity and the Induction of Tumor Necrosis Factor by Lipopeptide Analogs of the N-Terminal Part of Lipoprotein in the Outer Membrane of Escherichia coli.

1994 ◽  
Vol 17 (7) ◽  
pp. 980-982 ◽  
Author(s):  
Tadayori SHIMIZU ◽  
Yoshihisa IWAMOTO ◽  
Yasutake YANAGIHARA ◽  
Muneaki KURIMURA ◽  
Kazuo ACHIWA
Keyword(s):  
Escherichia Coli ◽  
Tumor Necrosis Factor ◽  
Outer Membrane ◽  
Tumor Necrosis ◽  
Mitogenic Activity ◽  
Terminal Part ◽  
Necrosis Factor

The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver

2003 ◽  
Vol 38 (5) ◽  
pp. 598-604 ◽  
Author(s):  
Juan J Dı́az-Gil ◽  
Pedro L Majano ◽  
Manuel López-Cabrera ◽  
Vicente Sánchez-López ◽  
Carmen Rúa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Rat Liver ◽  
Tumor Necrosis ◽  
Mitogenic Activity ◽  
Necrosis Factor Alpha ◽  
Liver Growth ◽  
Factor Alpha ◽  
Necrosis Factor

scholarly journals Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells.

1987 ◽  
Vol 166 (1) ◽  
pp. 235-245 ◽  
Author(s):  
K A Hajjar ◽  
D P Hajjar ◽  
R L Silverstein ◽  
R L Nachman
Keyword(s):  
Endothelial Cells ◽  
Growth Factor ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Umbilical Vein ◽  
Fold Increase ◽  
Mitogenic Activity ◽  
Platelet Derived Growth Factor ◽  
Adhesive Properties ◽  
Necrosis Factor

Platelet-derived growth factor (PDGF) is a 30,000-Mr glycoprotein that is chemotactic and mitogenic for vascular smooth muscle cells (SMC). It is also a potent vasoconstrictor. In the present study, we found that the macrophage-derived polypeptide, tumor necrosis factor (TNF), releases a factor from human umbilical vein endothelial cells (EC) that is mitogenic for SMC. Postculture medium from TNF-stimulated EC induced a 90% increase in mitogenesis is compared with controls. This effect was half-maximal at a TNF dose of 114 pM, reflected a 2.5-fold increase in PDGF-specific mRNA synthesis, and peaked at 15 h of TNF stimulation. Mitogenic activity was completely abrogated by preincubation of postculture medium with antibody to platelet PDGF. Stimulation of EC with IL-1 (60-240 pM) led to the release of similar mitogenic activity. Thus, in addition to its effects on the hemostatic and adhesive properties of EC, TNF also promotes release of PDGF, which may serve to modulate proliferation of vascular SMC during wound healing, inflammation, and atherogenesis.

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