scholarly journals Pharmacologically Relevant Receptor Binding Characteristics and 5α-Reductase Inhibitory Activity of Free Fatty Acids Contained in Saw Palmetto Extract

2009 ◽  
Vol 32 (4) ◽  
pp. 646-650 ◽  
Author(s):  
Masayuki Abe ◽  
Yoshihiko Ito ◽  
Luvsandorj Oyunzul ◽  
Tomomi Oki-Fujino ◽  
Shizuo Yamada
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Receptor Binding ◽  
Inhibitory Activity ◽  
Saw Palmetto ◽  
Binding Characteristics

Lipids and Free Fatty Acids of Red Sea Avrainvillea amadelpha, Holothuria atra, and Sarcocornia fruticosa Inhibit Marine Bacterial Biofilms

2020 ◽  
Vol 17 (6) ◽  
pp. 466-471
Author(s):  
Usama W. Hawas ◽  
Fekri Shaher ◽  
Mohamed Ghandourah ◽  
Lamia T. Abou El-Kassem ◽  
Sathianeson Satheesh ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Red Sea ◽  
Inhibitory Activity ◽  
Sea Cucumber ◽  
Bacterial Biofilms ◽  
Antibiofilm Activity ◽  
Bacterial Strains ◽  
Holothuria Atra ◽  
Sarcocornia Fruticosa

This study aimed at evaluating the antibiofilm activity of the Red Sea metabolites from green alga Avrainvillea amadelpha, sea cucumber Holothuria atra and costal plant Sarcocornia fruticosa against three biofilm bacterial strains isolated from Jeddah coast. Free fatty acids (FFAs) and other lipoidal matters were extracted from these organisms and analyzed by GC-MS. The composition of lipoidal fractions showed that A. amadelpha is rich by 74% saturated FAs, while sea cucumber H. atra revealed high content (60%) of unsaturated FAs. Palmitic acid is the major FA component in all species ranging from 14.5 to 26.7%. Phytol, sterols and hydrocarbons (C8-C29) were represented in the alga A. amadelpha as high contents with values 25.8, 21.9 and 18.5%, respectively. The extracts and lipoidal contents showed biofilm inhibitory activity against the isolated bacterial strains, where the unsaponified lipoidal fraction of S. fruticosa exhibited highest inhibitory activity against Planomicrobium sp. at concentration of 200 µg/mL.

scholarly journals Bioactive Lipids Metabolites in Amanita Virosa

2012 ◽  
Vol 7 (11) ◽  
pp. 1934578X1200701 ◽  
Author(s):  
Francesca Cateni ◽  
Marina Zacchigna ◽  
Bojan Doljak ◽  
Marko Anderluh ◽  
Giuseppe Procida ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Blood Coagulation ◽  
Inhibitory Activity ◽  
Complex Mixture ◽  
Serine Proteinase ◽  
Coagulation Cascade ◽  
Bioactive Lipids ◽  
Thrombin Inhibition ◽  
Suitable Target

Thrombin is the key serine proteinase of the coagulation cascade and, therefore, a suitable target for inhibition of blood coagulation. An extract of Amanita virosa considerably inhibited thrombin (48%), but showed no inhibitory activity on trypsin. On the basis of inhibition selectivity between thrombin and trypsin and potency of thrombin inhibition, A. virosa constitutes a good starting material for the isolation of further compounds that are active against thrombin. Bioassay oriented fractionation of the extract of A. virosa led to the isolation of a complex mixture of triglycerides (TGs), monoacylglycerols (MAGs), free fatty acids (FAs) and ergosterol. The structures of the isolated lipids metabolites were determined on the basis of chemical and spectroscopic evidences.

Muscarinic and Alpha 1-Adrenergic Receptor Binding Characteristics of Saw Palmetto Extract in Rat Lower Urinary Tract

Urology ◽  
2007 ◽  
Vol 69 (6) ◽  
pp. 1216-1220 ◽  
Author(s):  
Mayumi Suzuki ◽  
Tomomi Oki ◽  
Tomomi Sugiyama ◽  
Keizo Umegaki ◽  
Shinya Uchida ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Receptor Binding ◽  
Adrenergic Receptor ◽  
Lower Urinary Tract ◽  
Saw Palmetto ◽  
Binding Characteristics ◽  
Lower Urinary
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