A novel in vitro model for joint effects of alcohol and free fatty acids on hepatocellular steatosis and inflammation

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
A Mahli ◽  
WE Thasler ◽  
M Müller ◽  
C Hellerbrand
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
In Vitro Model ◽  
Joint Effects ◽  
Vitro Model

scholarly journals Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model

2015 ◽  
Vol 76 ◽  
pp. 109-115 ◽  
Author(s):  
Ileana Hernández ◽  
Mayra Domínguez-Pérez ◽  
Leticia Bucio ◽  
Verónica Souza ◽  
Roxana U. Miranda ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Oxidative Damage ◽  
Free Fatty Acids ◽  
In Vitro Model ◽  
Ethanol Metabolism ◽  
Vitro Model

Ethanol and fatty acids impair lipid homeostasis in an in vitro model of hepatic steatosis

2016 ◽  
Vol 90 ◽  
pp. 84-94 ◽  
Author(s):  
Giulia Vecchione ◽  
Elena Grasselli ◽  
Andrea D. Compalati ◽  
Milena Ragazzoni ◽  
Katia Cortese ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Hepatic Steatosis ◽  
In Vitro Model ◽  
Lipid Homeostasis ◽  
Vitro Model

Fatty acids, mercury, and methylmercury bioaccessibility in salmon (Salmo salar) using an in vitro model: Effect of culinary treatment

2015 ◽  
Vol 185 ◽  
pp. 268-276 ◽  
Author(s):  
Sara Costa ◽  
Cláudia Afonso ◽  
Carlos Cardoso ◽  
Irineu Batista ◽  
Nádia Chaveiro ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Salmo Salar ◽  
In Vitro Model ◽  
Vitro Model

scholarly journals Beyond the Scavenging of Reactive Oxygen Species (ROS): Direct Effect of Cerium Oxide Nanoparticles in Reducing Fatty Acids Content in an In Vitro Model of Hepatocellular Steatosis

Biomolecules ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 425 ◽  
Author(s):  
Marina Parra-Robert ◽  
Eudald Casals ◽  
Nuria Massana ◽  
Muling Zeng ◽  
Meritxell Perramón ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Liver Disease ◽  
Hepg2 Cells ◽  
In Vitro Model ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Vitro Model

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipids. Antisteatotic effects of cerium oxide nanoparticles (CeO2NPs) have recently been shown in animal models of liver disease. However, it is unclear whether the activity of CeO2NPs is related solely to the decrease in oxidative stress or, in addition, they directly decrease liver fatty acid accumulation. To address this question, in this work, we used an in vitro model of hepatocellular steatosis, exposing HepG2 cells to oleic and palmitic acid. Cell uptake of CeO2NPs and their effect on oxidative stress and viability of hepatic cells cultured with H2O2 were also evaluated. Results show that CeO2NPs were uptaken by HepG2 cells and reduced oxidative stress and improved cell viability. Treatment with oleic and palmitic acid increased lipogenesis and the content of different fatty acids. CeO2NPs reduced palmitic and stearic acid and most fatty acids consisting of more than 18 carbon atoms. These effects were associated with significant changes in elongase and desaturase activity. In conclusion, CeO2NPs directly protected HepG2 cells from cell injury in oxidative stress conditions and reduced fatty acid content in steatotic conditions by inducing specific changes in fatty acid metabolism, thus showing potential in the treatment of NAFLD.

Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood–brain barrier in vitro model

2011 ◽  
Vol 42 (3) ◽  
pp. 290-299 ◽  
Author(s):  
C. Navarro ◽  
I. González-Álvarez ◽  
M. González-Álvarez ◽  
M. Manku ◽  
V. Merino ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Blood Brain Barrier ◽  
In Vitro Model ◽  
Brain Barrier ◽  
Blood Brain ◽  
Vitro Model

scholarly journals Structure-Activity–Dependent Regulation of Cell Communication by Perfluorinated Fatty Acids using in Vivo and in Vitro Model Systems

2009 ◽  
Vol 117 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Brad L. Upham ◽  
Joon-Suk Park ◽  
Pavel Babica ◽  
Iva Sovadinova ◽  
Alisa M. Rummel ◽  
...  
Keyword(s):  
Fatty Acids ◽  
In Vitro Model ◽  
Cell Communication ◽  
Model Systems ◽  
Structure Activity ◽  
Vitro Model ◽  
Activity Dependent

scholarly journals Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity

2014 ◽  
Vol 1841 (12) ◽  
pp. 1648-1655 ◽  
Author(s):  
Madeleen Bosma ◽  
Dianne H. Dapito ◽  
Zoi Drosatos-Tampakaki ◽  
Ni Huiping-Son ◽  
Li-Shin Huang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
In Vitro Model ◽  
Vitro Model
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