scholarly journals Inhibitory Effects of Oligostilbenoids from the Bark of Shorea roxburghii on Malignant Melanoma Cell Growth: Implications for Novel Topical Anticancer Candidates

2016 ◽  
Vol 39 (10) ◽  
pp. 1675-1682 ◽  
Author(s):  
Hiroyuki Moriyama ◽  
Mariko Moriyama ◽  
Kiyofumi Ninomiya ◽  
Toshio Morikawa ◽  
Takao Hayakawa
Keyword(s):  
Cell Growth ◽  
Malignant Melanoma ◽  
Melanoma Cell ◽  
Inhibitory Effects ◽  
Malignant Melanoma Cell

scholarly journals Inhibitory Effects of Trehalose on Malignant Melanoma Cell Growth: Implications for a Novel Topical Anticancer Agent on the Ocular Surface

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Takashi Kudo ◽  
Kimio Takeuchi ◽  
Yu-ichi Ebina ◽  
Mitsuru Nakazawa
Keyword(s):  
Cell Cycle ◽  
Flow Cytometry ◽  
Cell Growth ◽  
Malignant Melanoma ◽  
Melanoma Cell ◽  
Ocular Surface ◽  
Melanoma Cells ◽  
Apoptotic Cells ◽  
Inhibitory Effects ◽  
Malignant Melanoma Cell

Purpose. To investigate the inhibitory effects of trehalose on malignant melanoma cell growth. Methods. We cultured human malignant melanoma cells in a medium containing trehalose (control/2.5%/5.0%/7.5%/10.0%) and used the MTT assay to evaluate the growth activities. Subsequently, trehalose was topically instilled on subconjunctivally inoculated melanoma cells in F334/NJcl-rmu/rmu rats, followed by a histopathological evaluation of tumor growth. Using flow cytometry, we compared the distribution of the cell cycle, rate of apoptotic cells, and intracellular factors related to the cell cycle in cultured melanoma cells after trehalose treatment. Results. The MTT study showed that proliferation of melanoma cells was significantly inhibited by ≧ 5% of trehalose concentrations in the culture media. Subconjunctivally inoculated melanoma cell masses were significantly smaller in eyes administered trehalose as compared to controls. Flow cytometry analyses demonstrated that the trehalose groups had increased rates of G2/M phase cells and apoptotic cells in the cell culture. These cells also exhibited increased expressions of cell-cycle inhibitory factors. Conclusions. The current results show trehalose inhibits malignant melanoma cell growth by inducing G2/M cell cycle arrest and apoptosis, suggesting trehalose as a potential candidate for a topical agent to inhibit proliferation of malignant tumor cells of the ocular surface.

scholarly journals 050 Malignant melanoma cell growth is prevented in the systemic inflammatory environment

2020 ◽  
Vol 140 (7) ◽  
pp. S5
Author(s):  
Y. Matsushima ◽  
K. Mizutani ◽  
S. Iida ◽  
A. Umaoka ◽  
K. Okada ◽  
...  
Keyword(s):  
Cell Growth ◽  
Malignant Melanoma ◽  
Melanoma Cell ◽  
Malignant Melanoma Cell

MicroRNA oncogenes and tumor suppressors controlling malignant melanoma cell growth, apoptosis, migration, and invasion.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 8549-8549 ◽  
Author(s):  
R. W. Georgantas ◽  
K. Streicher ◽  
W. Zhu ◽  
R. Carrasco ◽  
Z. Xiao ◽  
...  
Keyword(s):  
Cell Growth ◽  
Malignant Melanoma ◽  
Melanoma Cell ◽  
Tumor Suppressors ◽  
Migration And Invasion ◽  
Malignant Melanoma Cell
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