scholarly journals Effect of furosemide on plasma clearance, anticoagulant effect and protein binding of warfarin in rats.

1982 ◽  
Vol 5 (10) ◽  
pp. 829-840 ◽  
Author(s):  
TARO OGISO ◽  
MASAHIRO IWAKI ◽  
YOSHIMASA KONISHI
Keyword(s):  
Protein Binding ◽  
Plasma Clearance ◽  
Anticoagulant Effect

The Anticoagulant Effect, Plasma Clearance and Metabolism of the Enantiomers of Warfarin in Man

1972 ◽  
Vol 43 (6) ◽  
pp. 15P-16P
Author(s):  
D. S. Hewick ◽  
J. McEwen
Keyword(s):  
Plasma Clearance ◽  
Anticoagulant Effect

scholarly journals Human Prothrombin/Phospholipids Interaction. Competitive Effect of an Anticoagulant Venom Phospholipase A2

1977 ◽  
Author(s):  
G.A. Boffa ◽  
R. Benarous ◽  
M.C. Boffa
Keyword(s):  
Protein Binding ◽  
Phospholipase A2 ◽  
Binding Site ◽  
Anticoagulant Activity ◽  
Anticoagulant Effect ◽  
Competitive Effect ◽  
Chemical Denaturation ◽  
Photo Oxidation ◽  
Partial Chemical ◽  
Anticoagulant Property

The high anticoagulant activity of the phospholipase A2 isolated from a Viperidae venom was explained by the formation of a complex with phospholipid at its protein binding site (1). The anticoagulant effect was reversible with specific antiphospholipase A2 immunoglobulins.The interaction between 125 I prothrombin and phospholipid in the presence of calcium was impaired by the phospholipase. A competitive effect between prothrombin and the phospholipase was demonstrated. It did not appear sufficient to explain the anticoagulant property of the enzyme. This effect was abolished after photo-oxidation of the phospholipase. In the presence of another Viperidae phospholipase A2, devoid of anticoagulant activity, no competitive effect was observed.The presence of several sites responsible for anticoagulant, catalytic and recognition properties have been looked for by various partial chemical denaturation processes.

Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect

1976 ◽  
Vol 19 (5part1) ◽  
pp. 552-558 ◽  
Author(s):  
Avraham Vacobi ◽  
John A. Udall ◽  
Gerhard Levy
Keyword(s):  
Protein Binding ◽  
Serum Protein ◽  
Anticoagulant Effect ◽  
Serum Protein Binding ◽  
Body Clearance

Pharmacokinetics of Paracetamol, Diclofenac and Vidarabine during Plasma Exchange

1988 ◽  
Vol 11 (3) ◽  
pp. 195-200 ◽  
Author(s):  
F. Fauvelle ◽  
A. Leon ◽  
M.T. Niakate ◽  
O. Petitjean ◽  
L Guillevin
Keyword(s):  
Protein Binding ◽  
Plasma Exchange ◽  
High Performance ◽  
Plasma Clearance ◽  
Distribution Volume ◽  
Volume Distribution ◽  
Binding Characteristics ◽  
Low Protein ◽  
B Virus ◽  
Large Distribution

In order to establish guidelines for prescribing drugs in patients treated with plasma exchange (PE), we studied the pharmacokinetics of paracetamol (5 patients), diclofenac (4 patients) and vidarabine (3 patients) during one or several PE. Results were compared with those obtained without PE. Diclofenac and paracetamol were choosen because they presented different volume distribution and protein binding characteristics. Vidarabine was studied because we use it for the treatment of patients with polyarteritis nodosa related to hepatitis B virus. Diclofenac (100 mg) and paracetamol (1000 mg) were given 1 hour before PE. Samples were obtained 60 and 30 min before PE, every 15 min during PE and hourly for 2 hours after the end of PE. Vidarabine was given in continuous infusion, 15 mg/kg/d during the first week of treatment and 7.5 mg/kg/d during subsequent weeks. Samples were obtained before PE, 3 times during PE and every 30 min for 4 hours after the end of PE. Paracetamol, diclofenac, vidarabine and hypoxanthine arabinoside were assayed by high performance liquid chromatography. During each PE 60 ml/kg were removed and replaced by albumin. We found that 17% of diclofenac, 4.3% of paracetamol and 4.9% of vidarabine were removed during each session. Plasmapheresis clearance was 51% of plasma clearance for diclofenac, 15% for paracetamol and 10% for vidarabine. Drugs which are mainly removed during PE are those which are bound to proteins with a small distribution volume. Those drugs, such as diclofenac, must be administered after the end of each PE session. Drugs which present a large distribution volume and low protein binding can be given before the session. Vidarabine can be administered during PE without loss of effectiveness due to drug removal.

Properties of 3-(1-Phenyl-Propyl)-4-Oxycoumarin (Marcoumar®) in the Plasma when Tested in Normal Cases and under the Influence of Drugs

1968 ◽  
Vol 19 (03/04) ◽  
pp. 389-396 ◽  
Author(s):  
K Seiler ◽  
F Duckert
Keyword(s):  
Protein Binding ◽  
Blood Plasma ◽  
Plasma Protein ◽  
Maintenance Dose ◽  
Anticoagulant Effect ◽  
Half Time ◽  
Fluorimetric Method ◽  
Biological Half Time ◽  
Anticoagulant Drug

SummaryA fluorimetric method served to determine Marcoumar in blood plasma. The biological half-time of Marcoumar after an administration of 2.2 mg/10 kg is 6½ days. Variations in maintenance dose requirements seem not to be primarly determined by differences in absorption or excretion of the anticoagulant drug. In therapeutical concentrations about 99% of the drug are bound to plasma protein. Marcoumar can be displaced in vitro from plasma protein by different drugs. The anticoagulant effect is not increased in every case in which the anticoagulant is displaced in plasma from its protein binding.

scholarly journals Effect of digoxin on plasma clearance and anticoagulant effect of warfarin in rats.

1984 ◽  
Vol 7 (3) ◽  
pp. 186-194
Author(s):  
TARO OGISO ◽  
MASAHIRO IWAKI ◽  
YOSHIMASA KONISHI
Keyword(s):  
Plasma Clearance ◽  
Anticoagulant Effect

Transient Prealbumin- Associated Hyperthyroxinemia in TSH-Producing Pituitary Adenoma

1990 ◽  
Vol 29 (01) ◽  
pp. 40-43 ◽  
Author(s):  
W. Langsteger ◽  
P. Költringer ◽  
P. Wakonig ◽  
B. Eber ◽  
M. Mokry ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Pituitary Adenoma ◽  
Thyroid Hormones ◽  
Protein Binding ◽  
Alpha Subunit ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Free Thyroid Hormones ◽  
Transmission Computed Tomography

This case report describes a 38-year-old male who was hospitalized for further clarification of clinically mild hyperthyroidism. His increased total hormone levels, the elevated free thyroid hormones and the elevated basal TSH with blunted response to TRH strongly suggested a pituitary adenoma with inappropriate TSH incretion. Transmission computed tomography showed an intrasellar expansion, 16 mm in diameter. The neoplastic TSH production was confirmed by an elevated alpha-subunit and a raised molar alpha-sub/ATSH ratio. However, T4 distribution on prealbumin (PA, TTR), albumin (A) and thyroxine binding globulin (TBG) showed a clearly increased binding to PA (39%), indicating additional prealbumin-associated hyperthyroxinemia. The absolute values of PA, A and TBG were within the normal range. After removal of the TSH-producing adenoma, basal TSH, the free thyroid hormones and T4 binding to prealbumin returned to normal. Therefore, the prealbumin-associated hyperthyroxinemia had to be interpreted as a transitory phenomenon related to secondary hyperthyroidism (T4 shift from thyroxine binding globulin to prealbumin) rather than a genetically conditioned anomaly of protein binding.

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