Studies on Heterocyclic Compounds. XV. Synthesis of Furo [2, 3-d] pyridazine Derivatives.(4). Synthesis of 2-[2-(5-Nitro-2-furyl) vinyl]-4, 7-dichlorofuro-[2, 3-d] pyridazine and Related Compounds by the Wittig Reaction

1971 ◽  
Vol 19 (7) ◽  
pp. 1465-1469 ◽  
Author(s):  
SHIGETAKA YOSHINA ◽  
ISAMU MAEBA
Keyword(s):  
Heterocyclic Compounds ◽  
Wittig Reaction ◽  
Pyridazine Derivatives ◽  
Related Compounds

Synthesis of biologically active heterocyclic compounds from allenic and acetylenic nitriles and related compounds

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Marthe Carine Djuidje Fotsing ◽  
Dieudonné Njamen ◽  
Zacharias Tanee Fomum ◽  
Derek Tantoh Ndinteh
Keyword(s):  
Michael Addition ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Biologically Active ◽  
Polycyclic Compounds ◽  
One Step ◽  
Pharmaceutical Properties ◽  
Related Compounds ◽  
Acetylenic Acids ◽  
The Michael Addition

Abstract Cyclic and polycyclic compounds containing moieties such as imidazole, pyrazole, isoxazole, thiazoline, oxazine, indole, benzothiazole and benzoxazole benzimidazole are prized molecules because of the various pharmaceutical properties that they display. This led Prof. Landor and co-workers to engage in the synthesis of several of them such as alkylimidazolenes, oxazolines, thiazolines, pyrimidopyrimidines, pyridylpyrazoles, benzoxazines, quinolines, pyrimidobenzimidazoles and pyrimidobenzothiazolones. This review covers the synthesis of biologically active heterocyclic compounds by the Michael addition and the double Michael addition of various amines and diamines on allenic nitriles, acetylenic nitriles, hydroxyacetylenic nitriles, acetylenic acids and acetylenic aldehydes. The heterocycles were obtained in one step reaction and in most cases, did not give side products. A brief discussion on the biological activities of some heterocycles is also provided.

scholarly journals Studies on Heterocyclic Compounds. X. Synthesis of Furo [2, 3-d] pyridazine Derivatives. (1)

1969 ◽  
Vol 17 (10) ◽  
pp. 2158-2163 ◽  
Author(s):  
SHIGETAKA YOSHINA ◽  
ISAMU MAEBA ◽  
KOICHI HIRANO
Keyword(s):  
Heterocyclic Compounds ◽  
Pyridazine Derivatives

Pyridazine Derivatives and Related Compounds, Part 4. Pyrrolo[2,3-c]pyridazines and Furo[2,3-c]pyndazines, Synthesis and Some Reactions

1992 ◽  
Vol 47 (3) ◽  
pp. 418-423 ◽  
Author(s):  
Ali Deeb ◽  
Besher Bayoumy ◽  
Fathy Yasine ◽  
Rida Fikry
Keyword(s):  
Benzoyl Chloride ◽  
Acetyl Chloride ◽  
Carbon Disulphide ◽  
Chloroacetyl Chloride ◽  
Pyridazine Derivatives ◽  
Related Compounds

Ethyl 5-amino-3,4-diphenyl-7H-pyrrolo[2,3-c]pyridazine-6-carboxylate (1), ethyl 5-aminofuro[ 2,3-c]pyridazine-6-carboxylate (2) and 5-aminofuro[2,3-c]pyridazine-6-carboxamide (3), are obtained from 4-cyano-5,6-diphenyl-3(2H)-pyridazinone. 5-Acetamido and 5-chloroacetamido derivatives prepared from 1, undergo cyclization on heating to form 2-substituted pyridazino[4',3':4,5]pyrrolo[3,2-d]oxazin-4(5H)-one (5a, b). The reaction of 1 and 2 with hydrazine gave 6-carbohydrazide derivatives (7 a, b). Compound 3 undergoes condensation with acetyl chloride, chloroacetyl chloride, benzoyl chloride, formamide and carbon disulphide to furnish the corresponding pyrimido[4',5' :4,5]furo[2,3-c]pyridazin-4(3 H)-one derivatives. The reaction of 1 with o-aminophenol gave 3,4-diphenyl-11-oxo-10,11-dihydro-12H -pyridazino[ 4',3' :4,5]pyrrolo[3,2-b][1,5]benzoxazepine.

ChemInform Abstract: Synthetic Applications of Intramolecular Aza-Wittig Reaction for the Preparation of Heterocyclic Compounds

ChemInform ◽  
2010 ◽  
Vol 41 (21) ◽  
pp. no-no
Author(s):  
Francisco Palacios ◽  
Domitila Aparicio ◽  
Gloria Rubiales ◽  
Concepcion Alonso ◽  
Jesus M. de los Santos
Keyword(s):  
Heterocyclic Compounds ◽  
Wittig Reaction
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