scholarly journals Reaction Mechanism in Aromatic Heterocyclic Compounds. V. Kinetics of the Reaction of 4-Nitroquinoline 1-Oxide and Related Compounds with Thioglycolic Acid.

1963 ◽  
Vol 11 (6) ◽  
pp. 785-792 ◽  
Author(s):  
Toshihiko Okamoto ◽  
Michiya Itoh
Keyword(s):  
Reaction Mechanism ◽  
Heterocyclic Compounds ◽  
Thioglycolic Acid ◽  
Kinetics Of ◽  
Related Compounds ◽  
Aromatic Heterocyclic

The kinetics of hydration of tricalcium silicate

1970 ◽  
Vol 48 (21) ◽  
pp. 3291-3299 ◽  
Author(s):  
K. G. McCurdy ◽  
B. P. Erno
Keyword(s):  
Reaction Mechanism ◽  
Intermediate Product ◽  
Activation Energies ◽  
Tricalcium Silicate ◽  
Rate Data ◽  
Large Excess ◽  
First Order ◽  
Kinetics Of ◽  
Subsequent Decomposition

An investigation has been made of the kinetics of hydration of tricalcium silicate at several temperatures in a large excess of water in the presence of various added ions. The rate data have been interpreted by a reaction mechanism which involves: (a) the first order hydration of tricalcium silicate to form an intermediate product, 1.5CaO•SiO2, which can react by two pathways, (b) the direct first order decomposition of intermediate, 1.5CaO•SiO2, to form lime and silica or (b′) complexing of intermediate with silica and subsequent decomposition to form lime and silica. This reaction mechanism predicts the rate of production of base during the hydration. The effect of various added ions is interpreted in terms of the proposed mechanism.Rate constants and activation energies for the various steps in the proposed mechanism are reported.

The kinetics of the penetration of some representative anthelmintics and related compounds into Ascaris lumbricoides var. suis

Parasitology ◽  
1949 ◽  
Vol 39 (3-4) ◽  
pp. 281-290 ◽  
Author(s):  
A. R. Trim
Keyword(s):  
Ascaris Lumbricoides ◽  
Homogeneous Layer ◽  
Outermost Layer ◽  
Basic Group ◽  
Rate Of Penetration ◽  
Surface Active ◽  
Main Barrier ◽  
Kinetics Of ◽  
Related Compounds ◽  
Active Substances

1. The rate of penetration of some representative drugs into Ascaris lumbricoides var. suis has been measured.2. The series of 4-n-alkyl resorcinols shows a typical homologous series effect.3. l-Nicotine penetrates relatively slowly.4. Its rate of penetration is greatly influenced by the extent of dissociation of its methyl pyrrolidine basic group.5. The rate of penetration of nicotine is greatly accelerated in the presence of some surface active substances.6. Chloroform is the most rapidly penetrating substance studied, and its penetration is not significantly influenced by the presence of proteins, carbohydrates and fats and their products of digestion.7. An analysis of the experimental results shows that the outermost layer of the cuticle of Ascaris is probably the main barrier to penetration. It behaves as if it were a thin; homogeneous layer of lipoid.8. The significance of these results in the study of anthelmintics is assessed.

scholarly journals Synthesis and biological activity of 4-thiazolidinone derivatives of phenothiazine

2012 ◽  
Vol 77 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Ritu Sharma ◽  
Pushkal Samadhiya ◽  
Savitri Srivastava ◽  
Santosh Srivastava
Keyword(s):  
Antimicrobial Activity ◽  
Heterocyclic Compounds ◽  
Thioglycolic Acid ◽  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Knoevenagel Reaction ◽  
Antituberculosis Activity ◽  
Bacteria And Fungi ◽  
Derivatives Of ◽  
Anhydrous Zncl2

A new series of N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo-5-( substituted benzylidene)-1,3-thiazolidine-carboxamide, 5(as) have been synthesized. The cycloaddition reaction of thioglycolic acid with N-[3-(10H-phenothiazinyl)-propyl]-N?-[(substituted phenyl)-methylidene]- urea, 3(a-s) in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N-[3-(10H-phenothiazinyl)-propyl]-2-(substituted phenyl)-4-oxo- 1,3-thiazolidine-carboxamide, 4(a-s). The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa undergoes Knoevenagel reaction to yield 5(a-s). The structure of compounds 1, 2, 3(a-s), 4(a-s) and 5(a-s) were confirmed by IR, 1H NMR, 13C NMR, Fmass and chemical analysis. All above compounds were screened for their antimicrobial activity against some selected bacteria and fungi and for antituberculosis activity compounds have been screened against the bacterium M. tuberculosis.

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